权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The effect of an isthmus on conduction at rapid rates in atrial myocardiaum. Role of anisotropy

峡部对心房心肌快速传导的影响。

基本信息

批准号：
08670839
负责人：
ABE Haruhiko
金额：
$ 1.41万
依托单位：
University of Occupational and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

To test the hypotheses that slow conduction across an isthmus at rapid rate crilically depends on anisotropy, we studied conduction both parallel and perpendicular to cardiac fibers cross an isthmus. Using surgical techniques, we create lesions perpendicular and parallel to the longitudinal orientation of the sulcus terminalis in 8 dogs. Two types of lesions were created : Lesion#1 : the length of the isthmus was constant at 5 mm ; the width of the isthmus was 15 mm, and later narrowed to 10 mm ; pacing wave fronts were conducted perpendicular to cardiAc fibers (n=4). Lesion #2 : the width of the isthmus was constant at 10 mm ; the length of the isthmus was 5 mm, and then lenthen to 10 mm ; pacing wave fronts were conducted parallel to cardiac fibers (n=4). During rapid atrial pacing (from 200 msec to until either refractoriness at the pacing site or conduction block in the isthmus occurred), conduction was mapped over and around the isthmus using a very high dense electrode array with … More 190 electrodes. Prior tocreating an isthmus, conduction velocity when the impulse was conducted parallel to the cardiac fibers did not change significantly at all pacing rates. However, conduction velocity when the pacing impulse was conducted perpendicular to the cardiac fibers decreased significantly. No fractionated signals were recorded. After creation of lesion #conduction velocity when the impulse was conducted perpendicular to fiber orientation decreased significantly when the isthmus was narrower (no lesion vs. 15 mm : P=ns, vs. 10 mm : P<0.05). Fractionated signals were recorded in the isthmus during pacing rate>= 440 bpm and conduction block occurred in the center of the isthmus at a rate>=550 bpm. After creation of lesion #conduction velocity when the impulse was conducted parallel tio the fiber orientation did not decrease significantly even when the isthmus was longer (no lesion ns. 5 mm or 10 mm length of isthmus : P=ns). Neither fractionated signals nor conduction block were recorded at any pacing rate. Anisotropic conduction alone did not produce critical slowing of conduction at any pacing rate. However, anisotropic conduction plus a critical width of an isthmus produced marked slowing of conduction and also conduction block in the isthmus. Our data suggests that an isthmus may play an important role for producing the area(s) of slow conduction of reentrant circuits. Less

为了验证峡部的慢速传导主要取决于各向异性的假设，我们研究了峡部心脏纤维的平行和垂直传导。使用外科技术，我们创建病变垂直和平行于8条狗的终沟的纵向方向。创建了两种类型的病变：病变#1：峡部长度恒定为5 mm ;峡部宽度为15 mm，随后缩小至10 mm ;起搏波阵面垂直于cardiAc纤维进行（n=4）。病变2：峡部宽度恒定为10 mm ;峡部长度为5 mm，然后变长至10 mm ;平行于心脏纤维传导起搏波阵面（n=4）。在快速心房起搏期间（从200 msec到起搏部位出现不应或峡部出现传导阻滞），使用极高密度电极阵列标测峡部上方和周围的传导， ...更多信息 190个电极。在建立峡部之前，当脉冲平行于心脏纤维传导时，传导速度在所有起搏频率下均无显著变化。然而，当起搏脉冲垂直于心脏纤维传导时，传导速度显著降低。未记录到分级信号。在创建损伤后，当峡部较窄时，当脉冲垂直于纤维方向传导时，传导速度显著降低（无损伤vs. 15 mm：P=ns，vs. 10 mm：P<0.05）。起搏频率>= 440 bpm时峡部记录到碎裂信号，频率>=550 bpm时峡部中心出现传导阻滞。在创建损伤后，当脉冲平行传导时，纤维取向没有显著降低，即使峡部更长（无损伤ns.峡部长度5 mm或10 mm：P=ns）。在任何起搏频率下均未记录到碎裂信号或传导阻滞。在任何起搏频率下，单独的各向异性传导都不会产生严重的传导减慢。然而，各向异性传导加上峡部的临界宽度产生显著的传导减慢和峡部的传导阻滞。我们的数据表明，峡部可能在产生折返回路的慢传导区域中起重要作用。少

项目成果

期刊论文数量（77）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

安部治彦、長友敏寿、三浦靖史、荒木優、他: "上室性頻拍誘発による房室結節内回帰性頻拍中の頻尿の機序についての検討" 心臓. 29(suppl 4). 16-18 (1997)

Haruhiko Abe，Toshihisa Nagatomo，Yasushi Miura，Yu Araki，等：“室上性心动过速引起的房室结复发性心动过速的机制研究”Cardiac 29（增刊4）。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

安部治彦、花田秀幸、岩見康代、三浦靖史、他: "悪性神経調節性失神に対し、レート・ドロップ・レスポンス機能を有するペースメーカーが有用であった1症例" 心臓ペーシング. 13. 392-395 (1997)

Haruhiko Abe、Hideyuki Hanada、Yasuyo Iwami、Yasushi Miura 等人：“具有速率下降响应功能的起搏器对恶性神经调节性晕厥有用的案例”Cardiac Pacing。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

安部治彦、花田秀幸、岩見康代、中島康秀、合志清隆: "神経調節性失神(NMS)に対するβ遮断薬の有用性-Head up tilt試験(HUT)による短期予防効果と長期フォローアップ成績-" 心臓. 30(suppl 3). 107-108 (1998)

Haruhiko Abe、Hideyuki Hanada、Yasuyo Iwami、Yasuhide Nakajima、Kiyotaka Koshi：“β 受体阻滞剂对神经调节性晕厥 (NMS) 的有用性 - 抬头倾斜试验 (HUT) 的短期预防效果和长期随访结果“心脏。30（增补 3）。107-108（1998）