Apoptosis of Eccline Gland Epithelia in the skin from the ATL Patients and HTLV-I Healthy Carriers

ATL患者和HTLV-I健康携带者皮肤表皮腺上皮细胞凋亡

• 批准号: 12670830
• 负责人: SETOYAMA Mitsuru
• 金额: $ 1.92万
• 依托单位: Dept. of Dermatology, Miyazaki Medical College (2001-2002)Kagoshima University (2000)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670830/
• 关键词: Apoptosis; ATLL; Eccrinegland; HTLV-I; ATL; 汗腺上皮; 発汗異常; Apoptosis; Eccrine gland; Sicca Syndrome

We have studied and confirmed that HTLV-1 infects not only lymphoid cells but also vascular endothelial cells and sweat gland epithelia. And, it is well known that virus-infected cells frequently exhibit apoptosis.Thus, we investigated whether HTLV-1 infection caused apoptosis of the sweat gland epithelia in the specimen from ATLL patients and healthy HTLV-1 carriers.As the results, apoptotic epithelial cells of the sweat glands were recognized from seropositive donors (14 of 31 cases of ATLL, 1 of 8 cases of carrier), but seronegative them. These apoptotic glands were always associated with CD8+ and TIA-1+ cell infiltration. These results also suggested that the event is relevant to sweating disturbance shown in ATLL patients.

我们研究并证实HTLV-1不仅感染淋巴细胞，还感染血管内皮细胞和汗腺上皮。而且，众所周知，病毒感染的细胞经常表现出细胞凋亡。因此，我们在 ATLL 患者和健康 HTLV-1 携带者的标本中研究了 HTLV-1 感染是否引起汗腺上皮细胞凋亡。结果，从血清阳性供体中识别出凋亡的汗腺上皮细胞（31 例 ATLL 病例中的 14 例，8 例携带者中的 1 例），但 他们的血清呈阴性。这些凋亡腺体总是与 CD8+ 和 TIA-1+ 细胞浸润相关。这些结果还表明该事件与 ATLL 患者表现出的出汗障碍有关。

项目成果

瀬戸山 充: "成人T細胞白血病・リンパ腫について"皮膚病診療. 23(4). 349-352 (2001)

Mitsuru Setoyama：“关于成人 T 细胞白血病和淋巴瘤”皮肤病学 23(4) (2001)。

Mitsuru Setoyama, M.D., Ph.D., et al.: "Koebner phenomenon in 2 cases of adult T-cell leukemia/lymphoma"(投稿中).

Mitsuru Setoyama, M.D., Ph.D., et al.：“2 例成人 T 细胞白血病/淋巴瘤中的 Koebner 现象”（进行中）。

Mitsuru Setoyama, M.D., Ph.D., et al.: "Koebner phenomenon in 2 cases of adult T-cell leukemia"lymphoma. (submitted).

Mitsuru Setoyama, M.D., Ph.D., et al.：“2 例成人 T 细胞白血病的 Koebner 现象”淋巴瘤。

Mitsuru Setoyama, et al.: "Human T-cell lymphotropic virus type I infects eccrine sweat gland epithelia"Int. J. Cancer. 80. 652-655 (1999)

Mitsuru Setoyama 等人：“人类 T 细胞嗜淋巴细胞病毒 I 型感染小汗腺上皮细胞”Int.

天野正宏, 瀬戸山充他: "皮膚からみた成人T細胞白血病"日本皮膚科学会雑誌. 113. 1391-1398 (2003)

Masahiro Amano、Mitsuru Setoyama 等人：“从皮肤观察到的成人 T 细胞白血病”日本皮肤病学会杂志 113. 1391-1398 (2003)。