Comprehensive analyses of epigenetic abnormalities inadult T-cell leukemia/lymphoma (ATLL)
Comprehensive analyses of epigenetic abnormalities inadult T-cell leukemia/lymphoma (ATLL)
批准号:
22590312
负责人:
OKA Takashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们研究了非霍奇金淋巴瘤和成人T细胞白血病/淋巴瘤(ATLL)的发生和发展的表观遗传学机制。我们发现,表观遗传学异常,包括多梳抑制复合体(PRC)分子的不平衡表达,miRNA和mRNA的异常表达,以及DNA甲基化的异常,在ATLL的发病中起着重要的作用。
英文摘要
We investigated the epigenetic mechanism of onset and progression of non-Hodgikinlymphoma as well as adult T-cell leukemia/lymphoma (ATLL). We found that epigenetic abnormalities including unbalanced expression of Polycomb Repressive Complex (PRC) molecules, aberrant expression of miRNA and mRNA and also aberrant DNA methylation are playing the important role in the pathogenesis of ATLL.
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DOI:
--
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2012
期刊:
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--
发表时间:
2011
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[岡 剛史, 佐藤妃映, ABD AL-Kader Lamia, 神農陽子, 鷲尾佳奈, 高田尚良, 田村麻衣子, 村上一郎, 大内田守, 大島孝一, 宇都宮與, 吉野 正]
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2011
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Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry
免疫组化显示酪氨酸磷酸酶 SHP-1 在多系统中的表达高于单系统朗格汉斯细胞组织细胞增生症
DOI:
10.1007/s00428-011-1090-1
发表时间:
2011
期刊:
Virchows Arch
影响因子:
3.5
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DOI:
--
发表时间:
2011
期刊:
影响因子:
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作者:
[Lamia ABD AL-Kader, 岡 剛史, 高田尚良, 佐藤妃映, 村上一郎, 吉野 正]
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Rethinking the contract remedies ( 2006 )
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Molecular Pathological analyses of aberrant expression of the proteintyrosine phosphatase SHP1 gene in terms of lymphomagenesis/leukemogenesis.
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Re-examination of the cognitive and motivational effects of cross-categorization
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