Correlation of lung functioning test and lung parenchymal changes on HRCT in patients with smokers and nonsmokers

吸烟与非吸烟患者肺功能检查与HRCT肺实质变化的相关性

• 批准号: 12670850
• 负责人: HASHIMOTO Manabu
• 金额: $ 1.66万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670850/
• 关键词: lung; CT; smoking; たばこ; air trapping

Experimental studyWe evaluated lung attenuation and attenuation changes and frequency of air trapping (AT) with respiration and body positions on high-resolution CT. The difference in lung attenuation was a little larger in the supine position than prone position. We believe that CT assessment in the supine position is suitable for evaluating for lung parenchymal changes. ATwas seen in 67% of subjects. It appeared in dependent lung regions and disappeared after changing body positions. The ratio of lung cross-sectional area on expiratory scan to inspiratory scan was 0.52 on the group with AT, and 0.69 on the group without AT (P<0.001). Body mass index was also higher in subjects with AT (P<0.05) than those without AT.Clinical studyWe examined lung attenuation changes and presence of AT and emphysematous lung change on HRCT In 36 smokers and 23 non-smokers AT was found in 19 smokers (53%) and 19 non-smokers (89%) (p<0.05). Emphysematous change was found in 16 smokers (44%). Mean of the percent of the forced expiratory volume in 1 second (FEV1.0%) was severely decreased in smoker group (68%). It was 84% in nonsmoker group (P<0.001). We compared the presence of AT with lung functioning test in smoker group. There was remarkable difference (P<0. 001) in FEV1.0% between group with AT (76%) and group without AT (60%). In patients without AT, lung attenuation was somewhat lower than those with AT and lung attenuation change was less. There was no statistical difference in the lung functioning test between the patients with and without emphysematous change. Furthermore, there was no remarkable difference in the lung attenuation and attenuation changes between two groups. We concluded that the presence of AT is not pathological changes related smoking and other respiratory diseases. Absence of AT is strongly related to lower lung. functioning test in smokers.

实验研究在高分辨率CT上观察了呼吸和体位对肺的衰减和衰减变化以及空气潴留（AT）频率的影响。仰卧位的肺衰减差异略大于俯卧位。我们认为，仰卧位CT评估是合适的评估肺实质的变化。在67%的受试者中观察到AT。它出现在依赖性肺区，改变体位后消失。呼气相与吸气相的肺截面积比值，AT组为0.52，无AT组为0.69（P<0.001）。临床研究我们对36例吸烟者和23例非吸烟者进行了HRCT检查，发现吸烟者19例（53%）和非吸烟者19例（89%）存在AT，肺密度减低和肺气肿改变。16例（44%）吸烟者有肺气肿改变。吸烟组1秒用力呼气容积百分比（FEV1.0%）显著降低（68%）。非吸烟组为84%（P<0.001）。我们比较了吸烟组AT的存在与肺功能检查。两组比较差异有显著性（P<0. 05）。001)FEV1.0%在有AT组（76%）和无AT组（60%）之间差异有显著性（P <0.05）。无AT者肺衰减略低于有AT者，肺衰减改变较少，有肺气肿改变者与无肺气肿改变者肺功能检查差异无统计学意义。两组间肺密度及肺密度变化无显著性差异。结论：AT的存在与吸烟及其他呼吸系统疾病无关。AT的缺失与下肺密切相关。吸烟者的功能测试

项目成果

Sato K: "Comparison of dynamic magnetic resonance imaging and lung scintigraphy"Japanese J of Applied Physiology (Japanese). 32. 159-164 (2002)

佐藤K：“动态磁共振成像与肺闪烁扫描的比较”日本应用生理学杂志（日文）。

Hashimoto M: "Pulmonary CT findings in Acute mercury vapor exposure"Clinical Radiology. 56. 17-21 (2001)

Hashimoto M：“急性汞蒸气暴露中的肺部 CT 表现”临床放射学。

館 悦子: "呼吸による肺野面積変化とair trappingの関連〜正常ボランチアによるCT上の検討〜"臨床放射線. 48巻. 188-192 (2003)

Etsuko Tate：“呼吸和空气滞留导致的肺野面积变化之间的关系 - 使用正常志愿者进行 CT 检查 -”《临床放射学》第 48 卷，188-192 (2003)。

佐藤 公彦: "呼吸運動下のMRIと肺血流・肺換気シンチグラフィーとの対比"日本臨床生理学会雑誌. 32巻. 159-164 (2002)

Kimihiko Sato：“呼吸运动下 MRI 与肺血流/通气闪烁扫描的比较”日本临床生理学会杂志第 32 卷 159-164（2002 年）。

佐藤 公彦: "呼吸運動下のMRIと肺血流・肺換気シンチグラフィとの対比"日本臨床生理学会雑誌. 32. 159-164 (2002)

Kimihiko Sato：“呼吸运动下的 MRI 与肺血流/肺通气闪烁扫描的比较” 日本临床生理学会杂志 32. 159-164 (2002)。