Relationship between cognitive function and central neurotransmitter in chronic cerebral ischemia

慢性脑缺血认知功能与中枢神经递质的关系

• 批准号: 12671377
• 负责人: OGASAWARA Kuniaki
• 金额: $ 2.18万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671377/
• 关键词: cerebral ischemia; cognitive function; central neurotransmitter; ベンゾジアゼピン受容体; positron emission tomography; 脳酸素代謝; 血行力学的脳虚血; ベンゾジアセピン受容体

Because benzodiazepine receptors (BZR) are abundant in the cortex, an accumulation of ^<11>C-flumazenil which selectively bind to BZR may be useful as markers of neuron density. The aims of this study were to clarify the relationship between neuron density and cerebral oxygen metabolism and to investigate usefulness of ^<11>C-flumazenil PET for detecting of misery perfusion. Subjects consisted of 16 patients with either internal carotid or middle cerebral arterial occlusive disease who underwent PET. Regional cerebral blood flow (CBF), regional cerebral oxygen extraction fraction (OEF), regional cerebral metabolic rate for oxygen (CMRO_2) and regional cerebrovascular reserve capacity (CVRC) to acetazolamide were calculated. After CBF study, flumazenil binding potential was measured using [^<11>C]flumazenil bolus injection method. Forty eight ROIs were obtained in 16 patients. Flumazenil binding potential was correlated to CMRO_2 (r=0.337, p=0.0069), but in 7 of 48 ROIs, CMRO_2 decreased whereas flumazenil binding potential did not change. Seventeen of 29 ROIs with decreased CVRC showed high OEF and the remaining 12 showed normal OEF. Flumazenil binding potentials in ROIs with normal OEF were significantly lower than those with high OEF (p=0.0003). This study demonstrated that ^<11>C-flumazenil PET is useful for detecting of misery perfusion in patients with hemodynamic ischemia.

由于苯二氮卓类受体（BZR）在皮质中丰富，<11>选择性结合BZR的14 C-氟马西尼的蓄积可用作神经元密度的标志物。本研究的目的是阐明神经元密度与脑氧代谢的关系，并探讨<11>氟马西尼PET在检测脑血流灌注异常中的作用。受试者包括16例接受PET检查的颈内动脉或大脑中动脉闭塞性疾病患者。计算局部脑血流量（CBF）、局部脑氧摄取分数（OEF）、局部脑氧代谢率（CMRO_2）和局部脑血管储备能力（CVRC）。CBF研究后，使用[^<11>C]氟马西尼推注法测量氟马西尼结合潜力。16例患者共获得48个ROI。氟马西尼结合力与CMRO_2相关（r=0.337，p=0.0069），但在48个ROI中，有7个ROI的CMRO_2降低，而氟马西尼结合力没有变化。CVRC降低的29个ROI中有17个显示高OEF，其余12个显示正常OEF。在OEF正常的ROI中，氟马西尼结合潜力显著低于OEF高的ROI（p=0.0003）。本研究表明，<11>氟马西尼PET可用于检测血流动力学缺血患者的痛苦灌注。

项目成果

Ogasawara K, Ogawa A, et al.: "Effects of EC-IC bypass surgery on cognitive impairment in patients with hemodynamic cerebral ischemia"Surgical Neurology. (掲載予定).

小笠原 K、小川 A 等人：“EC-IC 旁路手术对血流动力学脑缺血患者认知障碍的影响”《外科神经病学》（待出版）。

Ogasawara K, Ogawa A, et al.: "Atypical finding of brain Tc-99m-ECD SPECT imaging in herpes simplex encephalitis"Ann Nucl Med. 16. 347-350 (2002)

小笠原 K、小川 A 等人：“单纯疱疹脑炎脑部 Tc-99m-ECD SPECT 成像的非典型发现”Ann Nucl Med。

Ogasawara K, Okuguchi T, Sasoh M, Kobayashi M, Yukawa H, Terasaki K, Inoue T, Ogawa A: "Qualitative versus quantitative assessment of cerebrovascular reactivity to acetazolamide using ^<123>I-IMP SPECT in patients with unilateral major cerebral artery occ

Ogasawara K、Okuguchi T、Sasoh M、Kobayashi M、Yukawa H、Terasaki K、Inoue T、Okawa A：“使用 ^<123>I-IMP SPECT 对单侧大脑大动脉患者的脑血管反应性对乙酰唑胺进行定性与定量评估

Ogasawara K, Ogawa A, et al.: "Super-early and Standard Tc-99m Ethyl Cysteinate Dimer SPECT Imaging in A Patient with Reperfusion Hyperemia of Acute Cerebral Embolism"Clinical Nuclear Medicine. (掲載予定). (2002)

小笠原 K、小川 A 等人：“急性脑栓塞再灌注充血患者的超早期和标准 Tc-99m 半胱氨酸乙酯二聚体 SPECT 成像”（即将出版）。

Kuniaki Ogasawara: "Brain SPECT studies using 99mTc-HMPAO and 99mTc-ECD early after recanalization by local intraarterial thrombolysis in patients with acute embolic middle cerebral artery occlusion"American Journal of Neuroradilogy. 22. 48-53 (2001)

Kuniaki Ogasawara：“急性栓塞性大脑中动脉闭塞患者局部动脉内溶栓再通后早期使用 99mTc-HMPAO 和 99mTc-ECD 进行脑部 SPECT 研究”《美国神经放射学杂志》。