Cerebral hyperperfusion and cognitive impairment after carotid endarterectomy are associated with free radicals produced during surgery

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The aim of the present study was to clarify relationship between development of postoperative cerebral hyperperfusion or cognitive impairment and value of free radicals produced during surgery using electrical spin trapping for blood obtained from catheter set at the jugular bulb in patients undergoing carotid endarterectomy. As a result, value of free radical production during surgery correlated with intensity of cerebral ischemia during carotid occlusion, and excessive free radical production caused postoperative cerebral hyperperfusion and cognitive impairment. Value of free radical production during surgery was significantly lower in patients with free radical scavenger, edaravone, than in those without.