Cerebral hyperperfusion and cognitive impairment after carotid endarterectomy are associated with free radicals produced during surgery

颈动脉内膜切除术后脑过度灌注和认知障碍与手术过程中产生的自由基有关

• 批准号: 20591694
• 负责人: OGASAWARA Kuniaki
• 金额: $ 2.83万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591694/
• 关键词: 脳血管障害学; 頚動脈内膜剥離術; 過灌流; 高次脳機能障害; フリーラジカル; 頸部頸動脈狭窄症; 内膜剥離術

The aim of the present study was to clarify relationship between development of postoperative cerebral hyperperfusion or cognitive impairment and value of free radicals produced during surgery using electrical spin trapping for blood obtained from catheter set at the jugular bulb in patients undergoing carotid endarterectomy. As a result, value of free radical production during surgery correlated with intensity of cerebral ischemia during carotid occlusion, and excessive free radical production caused postoperative cerebral hyperperfusion and cognitive impairment. Value of free radical production during surgery was significantly lower in patients with free radical scavenger, edaravone, than in those without.

本研究的目的是阐明术后脑过度灌注或认知功能障碍的发展与手术过程中产生的自由基的价值之间的关系，使用电自旋捕集从颈静脉球处的导管中获得的血液接受颈动脉内膜切除术的患者。结果表明，术中自由基产生的值与颈动脉闭塞时脑缺血的程度相关，过量的自由基产生导致术后脑灌注过度和认知功能障碍。手术过程中自由基产生的价值在使用自由基清除剂依达拉奉的患者中显著低于未使用的患者。

项目成果

Altered carotid plaque signal among different repetition times on T1-weighted magnetic resonance plaque imaging with self-navigated radial-scan technique

自导航径向扫描技术 T1 加权磁共振斑块成像中不同重复次数颈动脉斑块信号的改变

• 发表时间: 2010
• 期刊: Neuroradiology
• 影响因子: 2.8
• 作者: Narumi S;Sasaki M;Ohba H;Ogasawara K;Hitomi J;Mori K;OhuraK;Ono A;Terayama Y.
• 通讯作者: Terayama Y.

Difference in Tracer Delay-induced Effect among Deconvolution Algorithms in CT Perfusion Analysis: Quantitative Evaluation with Digital Phantoms

• DOI: 10.1148/radiol.2511080983
• 发表时间: 2009-04-01
• 期刊: RADIOLOGY
• 影响因子: 19.7
• 作者: Kudo, Kohsuke;Sasaki, Makoto;Shirato, Hiroki
• 通讯作者: Shirato, Hiroki

Prediction of malignancy grading using computed tomography perfusion imaging in nonenhancing supratentorial gliomas

• DOI: 10.1007/s11060-010-0433-0
• 发表时间: 2011-07-01
• 期刊: JOURNAL OF NEURO-ONCOLOGY
• 影响因子: 3.9
• 作者: Beppu, Takaaki;Sasaki, Makoto;Ogasawara, Kuniaki
• 通讯作者: Ogasawara, Kuniaki

頚動脈内膜剥離術中・後合併症のメカニズム

颈动脉内膜剥脱术中及术后并发症的机制

• 发表时间: 2010
• 作者: 岸田悠吾;夏目敦至;近藤豊;齋藤清;若林俊彦;小笠原邦昭
• 通讯作者: 小笠原邦昭

Simple Assessment of Cerebral Hemodynamics Using Single-Slab 3D Time-of-Flight MR Angiography in Patients with Cervical Internal Carotid Artery Steno-Occlusive Diseases: Comparison with Quantitative Perfusion Single-Photon Emission CT

• DOI: 10.3174/ajnr.a1389
• 发表时间: 2009-03-01
• 期刊: AMERICAN JOURNAL OF NEURORADIOLOGY
• 影响因子: 3.5
• 作者: Hirooka, R.;Ogasawara, K.;Ogawa, A.
• 通讯作者: Ogawa, A.