Analysis of pain cognition by neuro-imaging

神经影像学分析疼痛认知

• 批准号: 12671464
• 负责人: SHIBATA Masahiko
• 金额: $ 2.05万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671464/
• 关键词: alllodynia; complex regional pain syndrome; FMRI; neuro-imaging; capsokin; neuro imaging

We demonstrated the anatomical area of cerebral activation triggered by non-nociceptive stimulation in a single patient with allodynia using functional MRI evaluations. Cerebral activation with non-nociceptive stimulus was measured for both the painful right foot and the healthy left foot. The same measurements were carried out 3 month later, after confirming that the alludynia triggered an increase in activity in the primary and second somatosensory area, inferior parietal lobe, insula, medial prefrontal cortex, anterior cingulated cortex and supplementary motor area, whereas stimulation to the healthy side only resulted n activity in the primary somatosensory area and inferior parietal lobe. Three months later, after the symptoms of allodynia had disappeared, the same stimuli to the right foot showed a decrease in activation of only the primary and second somatosensory area.Allodynia is secondary to nerve injury or tissue damage. The mechanism of how allodynia is perceived is essentially unknown. In our case the patient presented signs which fit the criteria for CRPS type I. Although these symptoms ceased naturally, the allodynia seen in our patient was common to that of CRPS type I. We believe that our findings are significant for understanding the pathophysiology of allodynia seen in CRP type I.

我们证明了解剖区域的非伤害性刺激触发的脑激活在一个单一的患者异常性疼痛使用功能性MRI评价。用非伤害性刺激测量疼痛的右脚和健康的左脚的大脑激活。3个月后进行相同的测量，确认后，alludynia触发的活动增加的主要和第二躯体感觉区，下顶叶，颞叶，内侧前额叶皮层，前扣带皮层和辅助运动区，而刺激健康侧只导致在活动的主要躯体感觉区和下顶叶。三个月后，在异常性疼痛的症状消失后，同样的刺激右脚，只显示第一和第二躯体感觉区的激活减少。异常性疼痛是继发于神经损伤或组织损伤。异常性疼痛如何被感知的机制基本上是未知的。在我们的病例中，患者出现符合CRPS I型标准的体征。虽然这些症状自然消失，但我们患者的异常性疼痛与CRPS I型相同。我们相信我们的发现对于理解CRP I型异常性疼痛的病理生理学有重要意义。

项目成果

Masahiko Shibata et al.: "Complex regional pain syndrome Type I associated with amyotophic lateral selerosis"Clinical Journal of pain. 19. 69-70 (2003)

Masahiko Shibata 等人：“与肌萎缩侧索硬化相关的 I 型复杂区域疼痛综合征”《疼痛临床杂志》。

Takoo Iwakura, Masahiko Shibata et al.: "Functional MRI revealed the cultical representation of allodynia after immobilization"Journal of Japan Society of pain clinicians. Vol.10. 46-50 (2003)

Takoo Iwakura、Masahiko Shibata 等人：“功能 MRI 揭示了固定后异常性疼痛的文化表征”日本疼痛临床医师学会杂志。

岩倉健夫, 柴田政彦 他: "ギブス固定後に発現したallodying時の脳賦活領域-Functional MRIによる検討"日本ペイソクリニック学会誌. 10. 46-50 (2003)

Takeo Iwakura、Masahiko Shibata 等人：“石膏固定后的脑激活区域 - 使用功能性 MRI 进行检查”日本 Paysoclinic 学会杂志 10. 46-50 (2003)。

Masahiko Shibata et al.: "Complex regional pain synd1rome Type1 associated with amyotrophic lateral sclerosis"Clinical Journal of Pain. 19. 69-70 (2003)

Masahiko Shibata 等人：“与肌萎缩侧索硬化症相关的复杂区域疼痛综合征 1 型”《临床疼痛杂志》。