Reconstruction of the autonomic nerve controlling urogenital tract and its clinical application

控制泌尿生殖道的自主神经重建及其临床应用

• 批准号: 12671521
• 负责人: KIHARA Kazunori
• 金额: $ 2.11万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671521/
• 关键词: urogenital tract; autonomic nerve; reconstruction; clinical application; 臨床応用

The research results are as follows.I) Reconstruction of the canine pelvic nerve :(1) The pelvic nerve was reconstructed by end-to-end anastomosis in high frequency.(2) Either genitofemoral nerve grafting or colonic nerve frafting in the defect of the pelvic nerve repaired the pathway in high frequency.(3) Auto-transplantation of the canine bladder preserving nerve function succeeded.(4) Redistribution of the canine pelvic nerve to the neobladder succeeded. The hypogastric nerve was grafted between the pelvic nerve and colonic nerve which innervate the colon used as neobladder. After this operation, stimulation of the pelvic nerve elicited contraction of the neobladder in all 5 dogs examined.II) Reconstruction of the canine hypogastric nerve :(1) Spontaneous reconstruction of the canine hypogastric nerve after transection of its half length over a long period was demonstrated.(2) Either genistofemoral nerve grafting or colonic nerve grafting in the defect of the hypogastric nerve repaired the pathway in high frequency.III) Regeneration of the axon in the nerve graft was identified on microscopy or electron microscopy.IV) Clinically, both reconstruction of the lumbar splanchnic nerve for ejaculation and that of the corpus spongiosum nerve for erection were successful.

研究结果如下：1)犬盆神经重建：(1)骨盆神经高频端端吻合重建；(2)生殖股神经移植或骨盆神经缺损区结肠神经成形术高频修复路径；(3)犬膀胱保留神经功能的自体移植成功。(4)犬盆神经向新膀胱处的再分配成功。将腹下神经移植于盆腔神经和支配结肠的结肠神经之间，作为新膀胱术。2)犬下腹下神经重建：(1)犬腹下神经长时间切断后自发重建；(2)股神经或结肠神经移植修复途径的频率较高；(3)移植神经轴突在显微镜和电子显微镜下均可见；(4)临床上，用于射精的腰内脏神经和用于勃起的海绵体神经均成功重建。

项目成果

Kobayashi T. et al.: "Spontaneous reconstruction of the canine hypogastric nerve over a long period after removing half of its length"Auton. Neurosci-Vasic. 86. 151-162 (2001)

Kobayashi T. 等人：“犬腹下神经在切除一半长度后在很长一段时间内进行自发重建”Auton。

Kobayashi T., Kihara K., Kageyama Y., Yamada T., Liu S. and Sato K.: "Spontaneous reconstruction of the canirie hypogastric nerve over a long period after removing half of its length"Auton, Neurosci-Basic. 86. 151-162 (2001)

Kobayashi T.、Kihara K.、Kageyama Y.、Yamada T.、Liu S. 和 Sato K.：“犬腹下神经在切除一半长度后在很长一段时间内自发重建”Auton，神经科学基础。

Althog S. et al.: "Erectile Dysfunetion"Health publication Ltd. U.K.. 730 (2002)

Althog S. 等人：“勃起功能障碍”英国健​​康出版有限公司 730 (2002)

Yonese J. et al.: "Sympathetic efferent paitthways projeting to the prostate in the dog"Prostate. 44. 225-232 (2000)

Yonese J.等人：“狗的交感传出通路投射到前列腺”前列腺。

Kihara K. et al.: "Reconstruction of the canine pelvic nerve and its application to bladder transplantation"Neuvourol. Urodynam.. 20. 187-196 (2001)

Kihara K.等人：“犬盆神经的重建及其在膀胱移植中的应用”Neuourol。