HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)
HORNET 自主神经记录和刺激系统中心 (CARSS)
基本信息
- 批准号:10706622
- 负责人:
- 金额:$ 71.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-23 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcetylcholineAdoptedAntibodiesBladderCalibrationCatecholaminesChemicalsColonic PouchesDetectionDevelopmentDiseaseElectrodesElementsEncapsulatedEnsureEnzymesEquilibriumEsophagusEvaluationExocrine GlandsFilmImplantIn VitroIndividualIridiumLabelLiquid substanceLongevityLungMeasuresMembraneMethodologyModalityModificationMonitorMovementMyocardiumNervous SystemNeuromodulatorNeuronsNorepinephrineOrganOrgan TemperaturesParasympathetic Nervous SystemPatternPerformancePeriodicalsPeriodicityPeripheralPlatinumPolyurethanesPolyvinylsRelaxationRiskRoleSalineScanningSense OrgansSerumShapesSmooth MuscleSphincterStomachSurfaceSurgical suturesSystemTechnologyTemperatureTemperature SenseTestingThinnessWorkaptamerautonomic nervecell motilitydesignimplantationin vivoiridium oxidemultiplex detectionneuromuscularneuroregulationparyleneparylene Creceptorsensor
项目摘要
Physical and chemical sensing enables detection of functional states of individual end organs for state-
dependent neuromodulation. NEST 5 focuses on developing robust sensors for temperature, motility, pH,
acetylcholine, and catecholamines, and performing extensive benchtop testing to ensure reliable in vivo
performance for end organ sensing.
Proper functioning of end-organs is dependent on the local organ temperature. Therefore, accurate, in vivo
temperature sensing of end organs can provide valuable information on their functional states. We will develop
micropatterned platinum thin film-based resistive temperature sensors encapsulated in Parylene C for in vivo
temperature sensing.
Motility of certain end organs is associated with their functional states such as esophagus expansion and
sphincter contraction. We will develop resistive and capacitive strain sensors encapsulated in Parylene C or
polyurethane for motility sensing of target end organs. We will conformally coat commercial bend sensors with
Parylene C as encapsulation and suture them in a pre-bent configuration to convert contraction and expansion
to bending deformations. In parallel, we will conformally coat a commercial stretchable capacitive sensor with
polyurethane as stretchable encapsulation.
Acetylcholine functions both as a neuromuscular transmitter and neuromodulator, and is found in the central
and peripheral neurons, in target organs of the parasympathetic nervous systems. NEST 5 develops
electrochemical acetylcholine sensor using an enzyme-free sensing membrane doped with an organic and stable
receptor. We will integrate the sensing membrane in a Parylene-C based platinum microarray. The end-organ
electrochemical sensing of pH can be used for detecting functional states of individual end organs for enabling
state-dependent neuromodulation. We will develop a platinum microarray on a Parylene substrate and
electrodeposit iridium oxide as the active pH sensing material.
The end-organ electrochemical sensing of catecholamines, and norepinephrine (NE) in particular, can be
used for detecting the efficacy of autonomic neuromodulation on restoring the sympathetic-parasympathetic
balance, as well as functional or disease states in organs and the body. We will develop a platinum microarray
on a Parylene substrate and detecting catecholamines using the established methodology of fast scan cyclic
voltammetry. Extensive thermally accelerated benchtop testing will be performed in saline for all sensing
modules to de-risk the technology for long-term end organ sensing. Electrochemical sensing modules will be
tested pooled serum media (in addition to saline solutions) for evaluation of sensor biofouling.
物理和化学传感可检测各个终端器官的功能状态 - 状态 -
依赖性神经调节。 Nest 5专注于为温度,运动,pH,pH,
乙酰胆碱和儿茶酚胺以及进行广泛的台式测试以确保体内可靠
最终器官传感的性能。
末端的正确功能取决于局部器官温度。因此,精确的体内
最终器官的温度感知可以提供有关其功能状态的有价值的信息。我们将发展
微型图案基于薄膜的薄膜电阻温度传感器封装在parylene C中用于体内
温度传感。
某些末端器官的运动性与其功能状态相关,例如食管扩张和
括约肌收缩。我们将开发封装在Parylene C或的电容性应变传感器
聚氨酯用于靶心器官的运动感。我们将与
parylene c作为封装并将其缝合在弯曲前配置中以转换收缩和扩展
弯曲变形。同时,我们将与商业可拉伸的电容传感器一起覆盖
聚氨酯作为可拉伸封装。
乙酰胆碱既可以作为神经肌肉发射机和神经调节剂,并且在中央发现
和周围神经元,在副交感神经系统的靶器官中。 Nest 5开发
电化学乙酰胆碱传感器使用无酶掺杂有机且稳定的无酶传感膜
受体。我们将将传感膜整合在基于parylene-c的铂微阵列中。最终器官
pH的电化学感测可用于检测单个末端器官的功能状态以实现
国家依赖性神经调节。我们将在Parylene底物上开发铂微阵列,然后
氧化虹膜电偶氮作为活性pH传感材料。
儿茶酚胺和去甲肾上腺素(NE)的最终器官电化学感测,可以是
用于检测自主神经调节在恢复交感神经的疗效
在器官和人体中的平衡以及功能或疾病状态。我们将开发铂微阵列
使用既定的快速扫描循环的方法论,在戊烯基板上检测儿茶酚胺
伏安法。将在盐水中进行广泛的热加速台式测试以进行所有感应
降低技术以进行长期器官传感的模块。电化学传感模块将是
经过测试的合并血清培养基(除盐水溶液外),以评估传感器生物污染。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Maral Mousavi', 18)}}的其他基金
Building a two-way communication system: Bio-orthogonal superhydrophobic nanoparticles for controlled stimulation and real-time sensing of neurotransmitters
构建双向通信系统:生物正交超疏水纳米颗粒用于神经递质的受控刺激和实时传感
- 批准号:
10473375 - 财政年份:2022
- 资助金额:
$ 71.98万 - 项目类别:
HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)
HORNET 自主神经记录和刺激系统中心 (CARSS)
- 批准号:
10557006 - 财政年份:2022
- 资助金额:
$ 71.98万 - 项目类别:
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HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)
HORNET 自主神经记录和刺激系统中心 (CARSS)
- 批准号:
10557006 - 财政年份:2022
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$ 71.98万 - 项目类别: