Experimental study for ectopic osteoinduction with BMP and bone marrow induction
Experimental study for ectopic osteoinduction with BMP and bone marrow induction
批准号:
12671757
负责人:
KUSUMOTO Kenji
金额:
$2.11万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2002
中文摘要
以肌袋内骨形成蛋白(BMP)诱导成骨为研究模型,美国重组人BMP。在这项研究中,BMP不仅产生了小梁,还产生了骨髓血管样组织。在不同的条件下,对骨诱导进行了研究。1)在骨诱导过程中证实了BMP的表达。(2000-2002)2)在日本猕猴(Macaca Fuscata)(2002)(2002)的肌肉中可以诱导成骨。3)在植入rhBMP-2的肌瓣中,证实了其成骨作用,并通过血管造影术和组织学检查研究了血管形成和轴化。(2000-2002)4)重组人骨形态发生蛋白-2复合碱性成纤维细胞生长因子促进成骨。(2002)5)FK506影响rhBMP-2的成骨过程。(2002年)
英文摘要
Osteoinduction with BMP (Bone Morphogenetic Protein) in the muscle pocket is the research model, us* recombinant human BMP. In this research, BMP has produced not only trabeculae, but also bone marrow a* angioid tissue. In various conditions, osteoinduction has been investigated.1) BMP expression is confirmed in the course of osteoinduction. (2000-2002)2) Osteoinduction with rhBMP-2 can be produced in the muscle of Japanese monkey (Macaca Fuscata) (2002)3) In the muscle flap implanted rhBMP-2, osteoinduction is confirmed and vascular formation and axalization * investigated using angiogram and histological examination. (2000-2002)4) rhBMP-2 with bFGF promoted osteoinduction. (2002)5) FK506 affects the osteoinduction course with rhBMP-2. (2002)
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Kusumoto K,Bessho K,Fujimura K,Akioka J,Okubo Y,Ogawa Y,Iizuka T: "The effect of blood supply in a muscle and an elevated muscle flap on an endogenous tissue engineered bone by rhBMP-2 in the rat"Ann Plast Surg. 45. 408-414 (2000)
Kusumoto K、Bessho K、Fujimura K、Akioka J、Okubo Y、Okawa Y、Iizuka T:“肌肉中的血液供应和升高的肌肉瓣对大鼠中 rhBMP-2 内源性组织工程骨的影响”Ann
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Kaihara S, Bessho K, Okubo Y, Sonobe J, Kusumoto K, Ogawa Y, Iizuka T: "Effect of FK506 on osteoinduction by recombinant human bone morphogenetic protein-2"Life Sciences. 72. 247-256 (2002)
Kaihara S、Bessho K、Okubo Y、Sonobe J、Kusumoto K、Okawa Y、Iizuka T:“FK506 对重组人骨形态发生蛋白 2 骨诱导的影响”生命科学。
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Kusumoto K and Bessho K: "Jaw reconstruction with BMP, collagen and hydroxyapatite in vivo"R.G.Landes company, Austin, Texas. (in press).
Kusumoto K 和 Bessho K:“体内用 BMP、胶原蛋白和羟基磷灰石进行颌骨重建”R.G.Landes 公司,德克萨斯州奥斯汀。
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Kusumoto K and Bessho K: "Jaw reconstruction with BMP, collagen and hydroxyapatite"the World Scientific Publishing Co., Pte. Ltd.,. 307-328 (2002)
Kusumoto K 和 Bessho K:“用 BMP、胶原蛋白和羟基磷灰石进行下颌重建”,世界科学出版有限公司,Pte。
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Okubo Y, Bessho K, Fujimura K, Kusumoto K, Ogawa Y, Iizuka T: "Expression of bone morphogenetic protein in the course of osteoinduction by recombinant human bone morphogenetic protein-2"Clin Oral Impl Res. 13. 80-85 (2002)
Okubo Y、Bessho K、Fujimura K、Kusumoto K、Okawa Y、Iizuka T:“重组人骨形态发生蛋白-2在骨诱导过程中骨形态发生蛋白的表达”Clin Oral Impl Res。
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共 32 条
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