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Effect of occlusal interferences on dopamine release of prefrontal cortex in rats

咬合干扰对大鼠前额皮质多巴胺释放的影响

基本信息

批准号：
12671916
负责人：
MAEDA Teruta
金额：
$ 1.86万
依托单位：
Osaka Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671916/
关键词：
occlusion autonomic nerve response stress SDA

项目摘要

We investigated the relationship between the change of occlusion and the autonomic nerve response. Seven healthy adult subjects without symptoms of oral function were measured blood pressure (tonometory), heart rate, body temperature, fingertip blood flow, oxygen saturation. All subjects rested in an upright position on the dental chair. A 21 gauge intravenous catheter was inserted, and blood samples at rest were collected. Hemodynamics and plasma catecholamine were used as indication of stress. They wore the stabilization sprint on the maxilla which was divided into three parts (anterior than the first premolar and posterior than the second premolar).Immediately after wearing every combination of the sprints, the heart rate increased (p=0.053) compared with that in the resting condition, but blood pressure and fingertip blood flow did not change significantly. Five minutes after insertion of only an anterior part of sprint or an anterior and unilateral posterior parts of sprint, the plasma catecholamine were increased (p=0.1). The CV of R-R interval were changed during insertion of sprint, however, the large individual differences were statistically shown (p<0.000001).The present data suggest that experimental shortened dental arch influenced the autonomic nerve response, but it was not impossible to demonstrate statistically. We continue the experiment with additional conditions for overcoming a fault in the experiment.

我们研究了咬合变化与自主神经反应之间的关系。对七名无口腔功能症状的健康成年受试者进行了血压（眼压测量）、心率、体温、指尖血流量、血氧饱和度的测量。所有受试者都以直立姿势休息在牙科椅上。插入21号静脉导管，并采集静止时的血样。使用血流动力学和血浆儿茶酚胺作为应激指标。他们在上颌骨上佩戴了稳定冲刺，该稳定冲刺分为三个部分（第一前磨牙前面和第二前磨牙后面）。佩戴每种组合的冲刺后，与静息状态相比，心率立即增加（p = 0.053），但血压和指尖血流量没有显着变化。仅插入 sprint 前部或 sprint 前部和单侧后部插入后 5 分钟，血浆儿茶酚胺增加（p=0.1）。 R-R间期的CV在冲刺插入期间发生变化，但统计上显示出较大的个体差异（p<0.000001）。目前的数据表明，实验性缩短的牙弓影响自主神经反应，但并非不可能进行统计证明。我们在附加条件下继续实验以克服实验中的错误。