Effect of occlusal interferences on dopamine release of prefrontal cortex in rats

探讨咬合变化与自主神经反应的关系。对7名无口腔功能症状的健康成年受试者进行了血压（张力计）、心率、体温、指尖血流量、血氧饱和度的测定。所有受试者均以直立姿势躺在牙科椅上。插入21号静脉导管，并收集静息时的血样。血流动力学和血浆儿茶酚胺作为应激指标。在上颌第一前磨牙前、第二前磨牙后3个位置佩戴稳定型sprint，佩戴后即刻心率均较安静时增加（p=0.053），血压和指尖血流量无明显变化。仅插入sprint前部或sprint前部和单侧后部后5分钟，血浆儿茶酚胺增加（p=0.1）。R-R间期的变异系数在插入sprint过程中发生了变化，但个体差异较大（p<0.000001），提示实验性牙弓缩短对自主神经反应有影响，但并非不能用统计学方法加以证实。我们继续实验，增加了一些条件，以克服实验中的错误。

We investigated the relationship between the change of occlusion and the autonomic nerve response. Seven healthy adult subjects without symptoms of oral function were measured blood pressure (tonometory), heart rate, body temperature, fingertip blood flow, oxygen saturation. All subjects rested in an upright position on the dental chair. A 21 gauge intravenous catheter was inserted, and blood samples at rest were collected. Hemodynamics and plasma catecholamine were used as indication of stress. They wore the stabilization sprint on the maxilla which was divided into three parts (anterior than the first premolar and posterior than the second premolar).Immediately after wearing every combination of the sprints, the heart rate increased (p=0.053) compared with that in the resting condition, but blood pressure and fingertip blood flow did not change significantly. Five minutes after insertion of only an anterior part of sprint or an anterior and unilateral posterior parts of sprint, the plasma catecholamine were increased (p=0.1). The CV of R-R interval were changed during insertion of sprint, however, the large individual differences were statistically shown (p<0.000001).The present data suggest that experimental shortened dental arch influenced the autonomic nerve response, but it was not impossible to demonstrate statistically. We continue the experiment with additional conditions for overcoming a fault in the experiment.