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Influence of Missing Molar Teeth (SDA) on Stress Hormone in Saliva

缺失磨牙（SDA）对唾液中应激激素的影响

基本信息

批准号：
16591973
负责人：
MAEDA Teruta
金额：
$ 2.24万
依托单位：
Osaka Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591973/
关键词：
SDA Saliva Cortisol Chromogranin A Distal-extension RPD Stress

项目摘要

The purpose of this study is to elucidated relationship between missing molar teeth and the stresses hormone.Twenty-five patients (18 females and 7 males, average 62.1 year-old) whose unilateral or bilateral molar teeth were missing (Shortened Dental Arch 'SDA') were participated in this study. They were divided into 5 groups and were treated their denture by 5 dentists. All subjects were rested in an upright position on the dental chair, and asked to chew a cotton roll (salivette) for 2 min, which was to collect their saliva sample. The stages of saliva collection were immediately after interviewing, just before treatment, immediately after treatment, and before leaving hospital on the first visit, and at each subsequent visit, before and after treatment.Saliva samples were immediately frozen-50℃ for storage prior to assay, and cortisol and chromogranin A was measured by ELISA kit. Comparisons between before and after treatment of RPD were analyzed using an ANOVA with repeated measures.1. The concentrations of free salivary cortisol and chromogranin before treatment for the RPD at the first time of visit were significantly higher than those after treatment.2. When the patients were provided the removable partial denture (RPD) and satisfied with their denture, the concentration of salivary cortisol and chromogranin A decreased significantly compare with those at the other visits.3. After the patients removed their RPD for 3 days, the concentration of salivary cortisol and chromogranin A increase significantly.The present data suggest that SDA was a factor for a source of stress and that treatment of RPD should reduce the stress. However, as these results might involve many other factors, a new experimental model should be required for the analysis.

为探讨磨牙缺失与应激激素的关系，对25例单侧或双侧磨牙缺失（短牙弓“SDA”）的患者（男7例，女18例，平均年龄62.1岁）进行了研究。随机分为5组，由5名牙科医生进行义齿修复。所有受试者在牙科椅上直立休息，并要求咀嚼棉花卷（唾液）2 min，这是收集他们的唾液样本。分别在访视后即刻、治疗前即刻、治疗后即刻、首次访视出院前、后续每次访视、治疗前和治疗后即刻采集唾液样本，并在-50 ℃冷冻保存后进行检测，用ELISA试剂盒检测皮质醇和嗜铬粒蛋白A。RPD治疗前后的比较采用重复测量的方差分析. RPD治疗前第一次访视时唾液游离皮质醇和嗜铬粒蛋白浓度显著高于治疗后.当患者戴用可摘局部义齿并对义齿满意时，唾液皮质醇和嗜铬粒蛋白A浓度较其他访视时显著降低. RPD治疗3天后，患者唾液皮质醇和嗜铬粒蛋白A浓度明显升高，提示SDA是应激源之一，RPD治疗应减轻应激。然而，由于这些结果可能涉及许多其他因素，因此需要一个新的实验模型进行分析。

项目成果

期刊论文数量（32）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

実験的咬合干渉は自立神経活動に影響を及ぼすか? -短期間の咬合干渉付与の影響-

实验性咬合干扰是否会影响自主神经活动？ -短期咬合干扰的影响-

DOI：
发表时间：
2005
期刊：
日本補綴歯科学会雑誌 49・2
影响因子：
0
作者：
畦崎泰男;小池宏忠ほか
通讯作者：
小池宏忠ほか

Influence of Uncomfortable Removable Partial Dentures on Stress Hormone In Saliva

不舒服的可摘局部义齿对唾液中应激激素的影响

DOI：
发表时间：
2005
期刊：
Abstract of the 4th Biennial Congress of Asian Academy of Prosthodontics
影响因子：
0
作者：
Inoue H;Yamamoto S;Sakuma Y;Maeda T;Teruta Maeda
通讯作者：
Teruta Maeda

Effect of Change in Posture in Dental Chair on Heart Rate Variability and Salivary Cortisol

牙科椅姿势变化对心率变异性和唾液皮质醇的影响

DOI：
发表时间：
2005
期刊：
Abstract of the 11th Meeting of the International College of Prosthodontists
影响因子：
0
作者：
Inoue H;Yamamoto S;Sakuma Y;Maeda T;Teruta Maeda;Stanford et al.;Maeda T
通讯作者：
Maeda T

Are Occlusal Interferences Psychiatric Stress? Effect of Diazepam on Dopamine Release in Rats.

咬合干扰是精神压力吗？