Molecular determinants of myosin motor properties

肌球蛋白运动特性的分子决定因素

• 批准号: 5311372
• 负责人: Professor Dr. Martin Bähler
• 金额: --
• 依托单位: Institut für Molekulare Zellbiologie (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2001
• 资助国家: 德国
• 起止时间: 2000-12-31 至 2005-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5311372?language=en
• 关键词: Molecular; determinants; myosin; motor; properties

Myosin molecules are biomachines that produce mechanical force along the cytoskeletal actin filaments. Different myosin molecules differ considerably in their motor properties. It is thought that these differences in motor properties represent adaptations to their individually different cellular functions. We want to exploit these differences to figure out how the size of the myosin working stroke is determined and how the light chains that are associated with myosins regulate the motor properties. These studies should help to elucidate the basic chemo-mechanical mechanisms of myosin motor function and aid in the elucidation of their cellular functions.

肌球蛋白分子是沿细胞骨架肌动蛋白细丝产生机械力的生物机械。不同的肌球蛋白分子在其运动特性上有很大的不同。人们认为，运动特性的这些差异代表着它们对各自不同的细胞功能的适应。我们想利用这些差异来弄清楚肌球蛋白工作行程的大小是如何确定的，以及与肌球蛋白相关的轻链是如何调节马达特性的。这些研究将有助于阐明肌球蛋白运动功能的基本化学机械机制，并有助于阐明其细胞功能。