Signal-dependent generation and function of the actin filament arrays defined by SWAP-70

SWAP-70 定义的肌动蛋白丝阵列的信号依赖性生成和功能

• 批准号: 5407778
• 负责人: Professor Dr. Martin Bähler
• 金额: --
• 依托单位: Institut für Molekulare Zellbiologie (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5407778?language=en
• 关键词: Signal; dependent; generation; function; actin

A dynamic cytoskeleton allows cells to change their morphology and intracellular organization. The actin cytoskeleton consists of functionally different subsets of actin filament arrays that contribute to cell migration, shape changes, adhesion, and uptake of extracellular and plasma membrane components. We have identified a hitherto unrecognised dynamic subpopulation of actin filaments by the association with the protein SWAP-70. We now plan to elucidate the formation and function of this subpopulation of actin filaments. Furthermore, we want to understand what signaling pathways and molecular mechanisms control the targeting of SWAP-70 to these actin filaments and how SWAP-70 modulates the actin organization.

动态细胞骨架允许细胞改变其形态和细胞内组织。肌动蛋白细胞骨架由功能不同的肌动蛋白丝阵列子集组成，这些肌动蛋白丝阵列有助于细胞迁移、形状变化、粘附以及细胞外和质膜组分的摄取。我们已经确定了一个迄今未被认可的动态亚群肌动蛋白丝与蛋白质SWAP-70的协会。我们现在计划阐明肌动蛋白丝亚群的形成和功能。此外，我们希望了解什么信号通路和分子机制控制SWAP-70靶向这些肌动蛋白丝，以及SWAP-70如何调节肌动蛋白组织。