Influence of skeletal muscle triglyceride level on carbohydrates and/or lipida metabolism and body fat distribution

研究了骨骼肌甘油三酯水平对大鼠碳水化合物和/或脂质代谢和体脂分布的影响。在第一个实验中，发现骨骼肌中甘油三酯的积累会损害胰岛素作用和碳水化合物和/或脂质代谢，这使我们研究自愿轮跑（VR）训练是否会减少骨骼肌中甘油三酯的积累。研究还检查了训练引起的甘油三酯水平变化与骨骼肌或全身代谢特征之间是否存在一定程度的相关性。结果表明，VR训练降低了骨骼肌中的甘油三酯水平、血清中葡萄糖和甘油三酯的浓度以及腹部脂肪组织的积累。VR训练没有引起骨骼肌中柠檬酸合酶活性的显著增加。实验二验证了n型糖尿病模型OLETF大鼠骨骼肌中毛细血管的发育高于LETO对照组的假设。结果并不支持这一假设。第三个实验研究了阻力训练（RT）是否能改善骨骼肌的代谢能力，从而抑制骨骼肌和腹腔中甘油三酯的积累。还检测了RT是否降低了血清瘦素浓度。结果表明，RT抑制体重增加和腹部甘油三酯积累。RT训练大鼠血浆瘦素水平有降低的趋势，但无统计学意义。

Influence of skeletal muscle triglyceride level on carbohydrates and/or lipids metabolism and body fat distribution was investigated in the rat. In the first experiment, the finding that accumulation of triglyceride in the skeletal muscle impair insulin action and carbohydrates and/or lipids metabolism led us to examine whether or not voluntary wheel-running (VR) training decreased triglyceride accumulation in the skeletal muscle. It was also examined whether the correlations existed between a degree of the training-induced change of triglyceride level and metabolic characteristics in the skeletal muscle or whole body. The results indicated that VR training lowered triglyceride level in the skeletal muscle as well as the concentration of glucose and triglyceride in serum and an accumulation of abdominal adipose tissue. VR training induced no significant increase in citrate synthase activity in the skeletal muscle. The second experiment examined the hypothesis that capillarity is developed higher in the skeletal muscle of OLETF rat, a model of type n diabetes mellitus, than in those of control LETO rat. The results did not support the hypothesis. The third experiment investigated whether resistance training (RT) improved metabolic capacity of the skeletal muscle with resultant suppression of an accumulation of triglyceride in the skeletal muscle and abdominal cavity. It was also examined whether RT lowered the serum leptin concentration. The results showed that RT suppressed an increase of body weight and abdominal triglyceride accumulation. Though not significant statistically, a tendency of lower plasma leptin level existed in RT trained rats.