On health-promoting effects of resistance training

在本研究项目中，研究了阻力训练对大鼠和人类的健康促进作用。在第一个实验中，我们检测了阻力训练是否影响了大鼠足底肌肉中解偶联蛋白3的表达。阻力训练组大鼠通过爬1米高的笼子取水进行阻力训练。结果表明，抗阻训练对解偶联蛋白3的表达没有影响。实验二研究了耐力训练对大鼠血液中碳水化合物/脂肪代谢相关物质和脂肪细胞因子水平的影响。阻力训练与第一次实验相同。阻力训练显著降低附睾部、腹膜后和腹股沟脂肪垫重量。抗阻训练对血清脂肪细胞因子水平也有不同程度的影响，血清瘦素水平显著降低，而血清肿瘤坏死因子-α、脂联素和抵抗素水平无明显变化。抗阻训练后血清胰岛素浓度显著降低，但对血糖无明显影响，提示抗阻训练提高了胰岛素敏感性。第三个实验检测了运动强度不同的急性阻力运动是否会对男性血清脂肪细胞因子水平产生不同的影响。受试者以最大重复次数的20%或60%的强度进行下蹲、屈臂、压腿、靠边、伸腿和卧推。在对照条件下，受试者不进行任何运动。结果表明，急性抗阻运动对血清瘦素和脂联素水平无明显影响。

In the present study project, health-promoting effects of resistance training were investigated in rats and humans. In the first experiment, we examined if the resistance training affected uncoupling protein 3 expression in the plantar is muscles of rats. The rats of a resistance training group performed resistance training by climbing 1-m high cages for access to water. The results indicated that the expression of uncoupling protein 3 was not altered by the resistance training. In the second experiment, the effects of the resistance training on carbohydrate/fat metabolism-related substance and adipocytokine levels in the blood were studied in rats. The resistance training was the same as that of the first experiment. The resistance training significantly decreased the epididymal, retroperitoneal, and inguinal fat pad weights. The resistance training also induced differential effects on the serum adipocytokine levels with a significant decrement of the serum leptin concentration and no significant changes in the serum TNF-α, adiponectin, and resistin concentrations. A significantly lower serum insulin concentration was observed in the resistance training with no effect on the plasma glucose concentration, which suggest that the resistance training improved insulin sensitivity. The third experiment examined if acute resistance exercises varying in exercise intensity induced differential effects on serum adipocytokine levels in men. The subjects performed squat, arm curl, leg press, pull over, leg extension and bench press with the intensities of 20% or 60% of one repetition maximum. In the control condition, the subjects did not perform any exercise. It was shown that acute resistance exercises did not affect the serum leptin and adiponectin concentrations.