Importance of fiber type characteristics of the skeletal muscle as a determining factor for the degree of obesity

骨骼肌纤维类型特征作为肥胖程度决定因素的重要性

• 批准号: 09680110
• 负责人: MATOBA Hideki
• 金额: $ 2.11万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680110/
• 关键词: obesity; muscle fiber type; skeletal muscle; 安静時代謝; 筋線組みタイプ; 筋重量; 肥満ラット; 筋線維組成; 筋線維タイプ横断面積占有率

Three experiments were conducted in order to elucidate the role of fiber type characteristics of the skeletal muscle in determining the degree of obesity. In the first experiment, fiber type characteristics of the skeletal muscles of Zucker obese rat , the model animal with genetic predisposition for obesity, were compared with those of non-obese control rat. The results indicated that oxidative capacity of the skeletal muscle as a whole was lower in the Zucker rat, which was attributable to lower skeletal muscle mass. The second experiment examined the relationship between metabolic capacity of the skeletal muscle and abdominal fat deposition in the rat fed either high-fat diet or normal diet. In the rats fed normal diet, significant negative relationship existed between oxidative capacity of the skeletal muscle and abdominal fat weight. High-fat diet induced obesity despite the augmentation of the oxidative capacity of the skeletal muscle. The third experiment examined whether or not physical training employing voluntary wheel running, which is known to increase the oxidative capacity of the skeletal muscle and to suppress the deposition of abdominal fat, induced the change in resting metabolism or respiratory exchange ratio R. The results showed that the training induced no significant change in resting metabolic rate and R, despite a significant increase in MDH activity and a significant decrease in abdominal fat weight.

为了阐明骨骼肌的纤维类型特征在决定肥胖程度中的作用，进行了三个实验。在第一个实验中，比较了肥胖遗传易感性模型动物Zucker肥胖大鼠和非肥胖对照组大鼠骨骼肌的纤维类型特征。结果表明，Zucker大鼠的骨骼肌整体氧化能力较低，这是由于骨骼肌质量较低所致。第二个实验考察了喂食高脂饮食或正常饮食的大鼠的骨骼肌代谢能力和腹部脂肪沉积之间的关系。正常饮食大鼠骨骼肌氧化能力与腹脂重量呈显著负相关。尽管骨骼肌的氧化能力增强，但高脂肪饮食仍会导致肥胖。第三个实验考察了采用自主轮子跑的运动是否会引起静息代谢率和呼吸交换率的变化。结果表明，尽管MDH活性显著增加，腹部脂肪重量显著减少，但采用自愿车轮跑的运动是否会引起静息代谢率和呼吸交换率的变化。

项目成果

向井智春: "肥満ラットの骨格筋の組織化学的・生化学的特性"体力科学. 46. 643 (1997)

Tomoharu Mukai：“肥胖大鼠骨骼肌的组织化学和生化特征”《体质科学》46. 643（1997）。

的場秀樹: "肥満ラット骨格筋の化学的・生化学的特性(第2報)" 体力科学. 47・6. 966- (1998)

Hideki Matoba：“肥胖大鼠骨骼肌的化学和生物化学特征（第二次报告）”身体健康科学47・6。

向井智春ほか: "肥満ラットの骨格筋の組織化学的・生化学的特性" 体力科学. 46・6. 644 (1997)

Tomoharu Mukai 等：“肥胖大鼠骨骼肌的组织化学和生化特征”《体能科学》，46, 6. 644 (1997)。

Matoba Hideki: "Histochemical and biochemical properties of the skeletal muscle in obese rat (second report)."Japanese Journal of Physical Fitness and Sports Medicine. 47. 966 (1998)

场秀树：“肥胖大鼠骨骼肌的组织化学和生化特性（第二份报告）。”日本体能与运动医学杂志。

的場秀樹: "普通食あるいは高脂肪食で飼育されたラットの内臓脂肪重量,安静時代謝および骨格筋の酵素活性"日本運動生理学雑誌. 6・2. 89-91 (1999)

Hideki Matoba：“正常或高脂肪饮食的大鼠的内脏脂肪重量、静息代谢和骨骼肌酶活性”《日本运动生理学杂志》6・2（1999）。