权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

International comparison of subclinical atherosclerosis among the Japanese and American men aged 40-49

日本与美国40-49岁男性亚临床动脉粥样硬化的国际比较

基本信息

批准号：
13307016
负责人：
UESHIMA Hirotsugu
金额：
$ 28.12万
依托单位：
Shiga University of Medical Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

We conducted an international collaborative study, ERA JUMP (EBT and Risk Factor Assessment among Japanese and U.S. Men in the Post World-War II Birth Cohort), cooperating with the University of Pittsburgh and Pacific Health Research Institute in Hawaii. The purpose of this study was to elucidate and compare the progression of subclinical atherosclerosis among the Japanese and American men aged 40-49, and explore risk factors for atherosclerosis.We found the following results during the study period ; 1)the progression of subclinical atherosclerosis was severer in the Americans than in the Japanese, regardless of the unfavorable risk profile in the Japanese such as higher blood pressure, higher smoking prevalence, and similar levels of cholesterol, 2)the Japanese American men in Hawaii had severer levels of subclinical atherosclerosis than the Japanese men in Japan, indicating that the determinant of subclinical atherosclerosis is not genetic difference, and 3)physical activity did not seem to affect the progression of atherosclerosis, although we lacked in sufficient sample size and information in our pilot study on physical activity.For the purpose of standardization of blood sample examinations, samples were shipped to a laboratory in the University of Pittsburgh. We plan to examine lipoprotein profiles by NMR, emerging risk factors such as adipocytokines and possible genetic differences.Future directions of the study would be : 1)to elucidate the relationship between atherosclerosis and insulin resistance, 2)to add a new samples from South Korea whose risk profile is more favorable, but the progression of subclinical atherosclerosis is severer than the Japanese, and 3)to expand the age group in the Japanese

我们与匹兹堡大学和位于夏威夷的太平洋健康研究所合作，进行了一项国际合作研究ERA JUMP（日本和美国二战后出生人群中男性的EBT和风险因素评估）。本研究的目的是阐明和比较日本和美国40-49岁男性亚临床动脉粥样硬化的进展，并探讨动脉粥样硬化的危险因素。1）美国人亚临床动脉粥样硬化的进展比日本人更快，而不考虑日本人的不利风险特征，如高血压，较高的吸烟率和相似的胆固醇水平，2）在夏威夷的日裔美国人比在日本的日裔美国人具有更高水平的亚临床动脉粥样硬化，表明亚临床动脉粥样硬化的决定因素不是遗传差异，和3）体力活动似乎不影响动脉粥样硬化的进展，尽管我们在对体力活动的初步研究中缺乏足够的样本量和信息，但为了使血液样本检查标准化，样本被运送到匹兹堡大学的实验室。我们计划通过核磁共振检查脂蛋白谱，新兴的风险因素，如脂肪细胞因子和可能的遗传差异。未来的研究方向是：1）阐明动脉粥样硬化和胰岛素抵抗之间的关系，2）增加来自韩国的新样本，其风险特征更有利，但亚临床动脉粥样硬化的进展比日本人更快，3）扩大日本人的年龄组