A Cooperative epidemiologic Study of lifestyles for the prevention of hypertension: International study, INTERMAP

[引言]一项国际合作研究，调查营养素和食物摄入对血压的影响，已在4个国家的5 000人中进行;美国8个人群，日本4个，中国3个，英国2个。研究程序高度标准化。目前正在准备公布结果。[人群和方法]自1997年以来，在日本对40-59岁的男性和女性进行了INTERMAP研究的合作研究。在每一人口中随机挑选300人进行了调查，到1998年12月底，共有1 200名男女参加了调查。调查包括4天的24小时饮食回忆，8次血压测量和2天的24小时尿液收集。作为INTERMAP的辅助研究，分析了日本和夏威夷人群的血脂、纤维蛋白原、HbA 1c和其他因素。在夏威夷，267名男性和女性接受了调查。[结果与讨论]平均水平 关于我们 日本男性的收缩压为120.4 mmHg，与夏威夷相比，日本男性的收缩压低2.5 mmHg。女性血压水平低于男性。日本男性24小时尿液中的盐排泄量为12.3 g，比夏威夷男性高2 g。对于女性，尿盐排泄量在10-11 g之间。女性从脂肪中摄取的能量占总能量摄取的比例高于男性，即男性为21 - 24%，女性为25- 27%。此外，女性的多不饱和/饱和脂肪酸比例低于1.0，日本女性的血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯和纤维蛋白原水平低于夏威夷女性。相反，日本的HDL-胆固醇水平高于夏威夷。日本人的血清总胆固醇比夏威夷人低10-15 mg/dl。研究人员认为，这些发现与日本人比夏威夷人更高的鱼类消费量和更低的脂肪摄入量以及更低的体重指数有关。少

[Introduction] An international cooperative study to investigate the effect of nutrient and food intake on blood pressure has been carried out on 5 thousand people of 4 countries ; 8 populations in the USA, 4 in Japan, three in China and two in UK. The study procedure was highly standardized. The results are now being prepared for publication.[Populations and Methods] A cooperative study has been carried out for men and women aged 40-59 years old in Japan for the INTERMAP study since 1997. Three hundred people randomly selected in each population were surveyed and a total of 1,200 men and women had participated by the end of December 1998. The survey comprised 4 days of 24-hr dietary recall, blood pressure measurement 8 times and 2 days of 24-hr urine collection. As an ancillary study of the INTERMAP, serum lipids, fibrinogen, HbA1c and other factors were analyzed for Japanese and Hawaiian populations. In Hawaii, 267 men and women were surveyed.[Results and Discussion] The average leve … More l of systolic blood pressure for Japanese men was 120.4 mmHg and this was 2.5 mmHg lower in Japan compared to that in Hawaii. The blood pressure level of women was lower than that of men. Salt excretion in 24-hr urine collection was 12.3 g for Japanese men and this was 2 g higher than that for Hawaiians. For women, urinary salt excretion ranged between 10-11 g. The ratio of energy intake from fat to total energy intake was higher in women than in men, i.e. 21 to 24 % for men and 25-27 % for women. In addition, polyunsaturated/saturated fatty acid ratio was under 1.0 for women.Serum total cholesterol, LDL-cholesterol, triglycerides and fibrinogen levels were lower in Japan than in Hawaii. On the contrary, HDL-cholesterol was higher in Japan than in Hawaii. Serum total cholesterol in Japanese people was 10-15 mg/dl lower than that in Hawaii. It was considered that these findings were related to higher fish consumption and lower fat intake and lower body mass index in the Japanese populations compared to those in Hawaiians. Less