A Cooperative epidemiologic Study of lifestyles for the prevention of hypertension: International study, INTERMAP

【导语】一项调查营养和食物摄入对血压影响的国际合作研究对4个国家的5000人进行了研究；美国有8只，日本有4只，中国有3只，英国有2只。研究程序高度标准化。研究结果正在准备发表。【人群与方法】自1997年以来，日本开展了一项针对40-59岁男性和女性的合作研究。在每个人口中随机抽取300人进行了调查，到1998年12月底，共有1200名男女参加了调查。该调查包括4天的24小时饮食回忆、8次血压测量和2天的24小时尿液收集。作为INTERMAP的辅助研究，我们分析了日本和夏威夷人群的血脂、纤维蛋白原、HbA1c等因素。在夏威夷，267名男性和女性接受了调查。[结果与讨论]日本男性的平均收缩压为120.4毫米汞柱，比夏威夷低2.5毫米汞柱。女性的血压水平低于男性。在24小时尿液收集中，日本男性的盐排泄量为12.3克，比夏威夷人高出2克。对于女性，尿盐排泄量在10-11克之间。女性从脂肪中摄取的能量占总能量摄入的比例高于男性，即男性为21%至24%，女性为25%至27%。此外，女性的多不饱和脂肪酸/饱和脂肪酸比值低于1.0。日本人的血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯和纤维蛋白原水平低于夏威夷人。相反，高密度脂蛋白胆固醇在日本比在夏威夷高。日本人的血清总胆固醇比夏威夷人低10-15毫克/分升。人们认为，这些发现与日本人比夏威夷人吃更多的鱼、摄入更少的脂肪和更低的体重指数有关。少

[Introduction] An international cooperative study to investigate the effect of nutrient and food intake on blood pressure has been carried out on 5 thousand people of 4 countries ; 8 populations in the USA, 4 in Japan, three in China and two in UK. The study procedure was highly standardized. The results are now being prepared for publication.[Populations and Methods] A cooperative study has been carried out for men and women aged 40-59 years old in Japan for the INTERMAP study since 1997. Three hundred people randomly selected in each population were surveyed and a total of 1,200 men and women had participated by the end of December 1998. The survey comprised 4 days of 24-hr dietary recall, blood pressure measurement 8 times and 2 days of 24-hr urine collection. As an ancillary study of the INTERMAP, serum lipids, fibrinogen, HbA1c and other factors were analyzed for Japanese and Hawaiian populations. In Hawaii, 267 men and women were surveyed.[Results and Discussion] The average leve … More l of systolic blood pressure for Japanese men was 120.4 mmHg and this was 2.5 mmHg lower in Japan compared to that in Hawaii. The blood pressure level of women was lower than that of men. Salt excretion in 24-hr urine collection was 12.3 g for Japanese men and this was 2 g higher than that for Hawaiians. For women, urinary salt excretion ranged between 10-11 g. The ratio of energy intake from fat to total energy intake was higher in women than in men, i.e. 21 to 24 % for men and 25-27 % for women. In addition, polyunsaturated/saturated fatty acid ratio was under 1.0 for women.Serum total cholesterol, LDL-cholesterol, triglycerides and fibrinogen levels were lower in Japan than in Hawaii. On the contrary, HDL-cholesterol was higher in Japan than in Hawaii. Serum total cholesterol in Japanese people was 10-15 mg/dl lower than that in Hawaii. It was considered that these findings were related to higher fish consumption and lower fat intake and lower body mass index in the Japanese populations compared to those in Hawaiians. Less