A study on determinants of subclinical atherosclerosis

我们建议在六年内（2009年至2015年）完成对参与者的随访检查（n. 1300名年龄在40-79岁之间的人），我们之前随机抽样。在2005年至2011年的提案中，我们计划对约500名参与者进行随访检查。截至2012年3月底，我们已经对700多名参与者进行了跟踪检查，远远超过了计划人数。另一个附属计划，将我们的队列与美国多种族动脉粥样硬化研究进行比较，进展良好。此外，我们还报道了亚临床动脉粥样硬化的患病率，即冠状动脉钙化（CAC）和颈动脉内膜中层厚度（IMTC），以及血清脂蛋白相关磷脂酶A2水平与亚临床动脉粥样硬化指标之间的相关性（即：e. CAC，IMTC），使用来自日本普通人群的随机样本

We proposed to complete the follow-up examination over six years(2009 through 2015) on the participants(n. 1, 300, age 40-79 years) we randomly sampled previously. In this proposal covering year 2005 to 2011, we planned to run follow-up examination approximately 500 participants. By the end of March 2012, we have done the follow-up examination on more than 700 participants, well beyond the planned number. Another subsidiary plan, a comparison of our cohort with the Multi-Ethnic Study of Atherosclerosis in US, is in good progress. Furthermore, we have reported prevalence of subclinical atherosclerosis, namely coronary artery calcification(CAC) and intima-media thickness of the carotid artery(IMTC), as well as association between serum levels of lipoprotein-associated phospholipase A2 and those measures of subclinical atherosclerosis(i. e. CAC, IMTC) using a random sample from a general Japanese population