A study on determinants of subclinical atherosclerosis

亚临床动脉粥样硬化的决定因素研究

• 批准号: 21249043
• 负责人: UESHIMA Hirotsugu
• 金额: $ 28.87万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249043/
• 关键词: 動脈硬化; 公衆衛生学; 疫学; 国際共同研究; 一般住民; 一般地域住民

We proposed to complete the follow-up examination over six years(2009 through 2015) on the participants(n. 1, 300, age 40-79 years) we randomly sampled previously. In this proposal covering year 2005 to 2011, we planned to run follow-up examination approximately 500 participants. By the end of March 2012, we have done the follow-up examination on more than 700 participants, well beyond the planned number. Another subsidiary plan, a comparison of our cohort with the Multi-Ethnic Study of Atherosclerosis in US, is in good progress. Furthermore, we have reported prevalence of subclinical atherosclerosis, namely coronary artery calcification(CAC) and intima-media thickness of the carotid artery(IMTC), as well as association between serum levels of lipoprotein-associated phospholipase A2 and those measures of subclinical atherosclerosis(i. e. CAC, IMTC) using a random sample from a general Japanese population

我们建议在六年内(2009年至2015年)完成对先前随机抽样的1300名参与者(40-79岁)的随访检查。在这项涵盖2005至2011年的建议中，我们计划对约500名参与者进行跟踪检查。截至2012年3月底，我们已对700多名参与者进行了跟踪检查，远远超出了计划人数。另一项辅助计划，将我们的队列与美国动脉粥样硬化的多种族研究进行比较，进展良好。此外，我们报告了亚临床动脉粥样硬化的患病率，即冠状动脉钙化(Cac)和颈动脉内中膜厚度(Imtc)，以及血清脂蛋白相关磷脂酶A2水平与亚临床动脉粥样硬化指标(即cac，imtc)之间的关系。

项目成果

日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討

检查日本和美国当地居民队列 CT 冠状动脉钙化评分的可比性

• 发表时间: 2011
• 作者: 藤吉朗;関川暁;大久保孝義;三浦克之;門脇崇;上島弘嗣;他ERAJUMPリサーチグループ
• 通讯作者: 他ERAJUMPリサーチグループ

Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese Population.

脂蛋白相关磷脂酶 A2 与一般日本男性人群中亚临床颈动脉粥样硬化的风险相关。

• 发表时间: 2012
• 作者: Hirotsugu Ueshima;Takashi Kadowaki;Katsuyuki Miura;et. al.
• 通讯作者: et. al.

Subclinical Atherosclerosis ofCarotid Arteries among Apparently Healthy Japanese Men and Women : The Shiga Epidemiological Study of Subclinical Atherosclerosis

日本健康男性和女性的颈动脉亚临床动脉粥样硬化:滋贺县亚临床动脉粥样硬化流行病学研究

• 发表时间: 2012
• 作者: Aya Kadota;Katsuyuki Miura;Hirotsugu Ueshima;et. Al.
• 通讯作者: et. Al.

The prevalence of aortic calcification in Japanese compared to white and Japanese-American middle-aged men is confounded by the amount of cigarette smoking

• DOI: 10.1016/j.ijcard.2011.12.060
• 发表时间: 2013-07-15
• 期刊: INTERNATIONAL JOURNAL OF CARDIOLOGY
• 影响因子: 3.5
• 作者: El-Saed, Aiman;Curb, J. David;Sekikawa, Akira
• 通讯作者: Sekikawa, Akira

Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP Study

• DOI: 10.3945/ajcn.2009.28500
• 发表时间: 2010-05-01
• 期刊: AMERICAN JOURNAL OF CLINICAL NUTRITION
• 影响因子: 7.1
• 作者: Choo, Jina;Ueshima, Hirotsugu;Sekikawa, Akira
• 通讯作者: Sekikawa, Akira