A study on determinants of subclinical atherosclerosis

我们建议在六年内(2009年至2015年)完成对先前随机抽样的1300名参与者(40-79岁)的随访检查。在这项涵盖2005至2011年的建议中，我们计划对约500名参与者进行跟踪检查。截至2012年3月底，我们已对700多名参与者进行了跟踪检查，远远超出了计划人数。另一项辅助计划，将我们的队列与美国动脉粥样硬化的多种族研究进行比较，进展良好。此外，我们报告了亚临床动脉粥样硬化的患病率，即冠状动脉钙化(Cac)和颈动脉内中膜厚度(Imtc)，以及血清脂蛋白相关磷脂酶A2水平与亚临床动脉粥样硬化指标(即cac，imtc)之间的关系。

We proposed to complete the follow-up examination over six years(2009 through 2015) on the participants(n. 1, 300, age 40-79 years) we randomly sampled previously. In this proposal covering year 2005 to 2011, we planned to run follow-up examination approximately 500 participants. By the end of March 2012, we have done the follow-up examination on more than 700 participants, well beyond the planned number. Another subsidiary plan, a comparison of our cohort with the Multi-Ethnic Study of Atherosclerosis in US, is in good progress. Furthermore, we have reported prevalence of subclinical atherosclerosis, namely coronary artery calcification(CAC) and intima-media thickness of the carotid artery(IMTC), as well as association between serum levels of lipoprotein-associated phospholipase A2 and those measures of subclinical atherosclerosis(i. e. CAC, IMTC) using a random sample from a general Japanese population