Rho-kinase activity in circulating neutrophils as a useful biomarker for diagnosis and disease activity assessment of vasospastic angina

循环中性粒细胞中的 Rho 激酶活性作为血管痉挛性心绞痛诊断和疾病活动评估的有用生物标志物

• 批准号: 23591026
• 负责人: YASUDA Satoshi
• 金额: $ 3.33万
• 依托单位: National Cardiovascular Center Research Institute (2012-2013)Tohoku University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591026/
• 关键词: ストレス; 循環器・高血圧; トランスレーショナルリサーチ

We examined whether Rho-kinase activity is systemically enhanced in vasospastic angina (VSA) patients. The Rho-kinase activity was significantly higher in the VSA group than in the non-VSA group. We also found that Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress and that Rho-kinase activity exhibits distinct circadian variation associated with alterations in coronary vasomotor responses. These results indicate that Rho-kinase activity in circulating neutrophils may be a useful biomarker for diagnosis and disease activity assessment of the vasospastic disorder.

我们研究了血管痉挛性心绞痛（VSA）患者的Rho激酶活性是否全身增强。Rho激酶活性在VSA组显著高于非VSA组。我们还发现，VSA患者的Rho激酶活性短暂增强与灾害相关的精神压力，Rho激酶活性表现出明显的昼夜变化与冠状动脉血管反应的改变。这些结果表明，Rho激酶活性在循环中性粒细胞可能是一个有用的生物标志物的诊断和疾病活动评估的血管痉挛性疾病。

项目成果

Circadian Variation of Rho-kinase Activity in Circulating Leukocytes in Patients with Vasospastic Angina Circulation Journal 2014, 78(Suppl. I) : I-597

血管痉挛性心绞痛患者循环白细胞 Rho 激酶活性的昼夜变化 Circulation Journal 2014, 78(Suppl. I) : I-597

• 发表时间: 2014
• 作者: Taro Nihei;Jun Takahashi;Yoku Kikuchi;Kiyotaka Hao;Yusuke Takagi;Ryuji Tsuburaya;Takashi Shirato;Yoshitaka Itoh;Yasuharu Matsumoto;Masaharu Nakayama;Kenta Ito;Hiroaki Shimokawa
• 通讯作者: Hiroaki Shimokawa

Increased Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake disaster.

东日本大地震灾难后血管痉挛性心绞痛患者 Rho 激酶活性增加。

• 发表时间: 2012
• 作者: Nihei T;Takahashi J;Kikuchi Y;Ito Y;Tsuburaya R;Takagi Y;Nakayama M;Ito K;Yasuda S;Shimokawa H.
• 通讯作者: Shimokawa H.

東北大学循環器内科

东北大学心脏病学系

Vasospastic limb ischemia presenting acute and chronic limb ischemia

血管痉挛性肢体缺血表现为急性和慢性肢体缺血

• 发表时间: 2014
• 期刊: Ann Vasc Dis
• 影响因子: 0.8
• 作者: Kaneyama J;Kawarada O;Sakamoto S;Harada K;Ishihara M;Yasuda S;Hisao O.
• 通讯作者: Hisao O.

The Pathogenesis of Vasospastic Angina. In : Kaski JC, Eslick GD, Bairey Merz CN (eds.), Chest Pain with Normal Coronary Arteries

血管痉挛性心绞痛的发病机制。

• 发表时间: 2013
• 作者: Yasuda S;Shimokawa H.
• 通讯作者: Shimokawa H.