Shining nanoparticles for single microRNA detection in microfluidics

用于微流控中单个 microRNA 检测的发光纳米颗粒

• 批准号: DE220100311
• 负责人: Dr Riikka Arppe-Tabbara
• 金额: --
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2022-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100311
• 关键词: Shining; nanoparticles; single; microRNA; detection

This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The multiplexed platform has the potential to benefit the biomedical research of microRNAs and opens up a genuine commercialisation potential for portable biosensing of nucleic acids.

本项目旨在广泛研究纳米颗粒与核酸之间的界面。它着手生产一种新型的超灵敏高性能生物传感平台，该平台将发光纳米颗粒与微流体相结合，用于数字分析。这种便携式平台将在单分子水平上检测生物指纹或microrna，提供前所未有的灵敏度和特异性。该多路复用平台有可能有利于微小rna的生物医学研究，并为便携式核酸生物传感开辟了真正的商业化潜力。