权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The comprehensive studies for establishment of a system to prevent periodontitis in adolescent students

建立青少年学生牙周炎预防体系的综合研究

基本信息

批准号：
13307060
负责人：
HASEGAWA Kohji
金额：
$ 34.44万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13307060/
关键词：
Adolescent student Periodontitis Presymptomatic diagnosis Risk factor Screening system Epidemiological study Periodontal disease condition Medicine for prevention treatment of periodontitis

项目摘要

To establish a system to prevent periodontitis in adolescent students, we investigated for 3 years (2001-2003) in this research project, and the following results were obtained.1. Epidemiological studies in this research project demonstrated that periodontal conditions worsened with increased age in adolescent students.2. It was possible that the screening for students with high risk sites of periodontitis in school dental health examination contributed to the subsequent improvement of periodontal conditions in those students.3. It was clarified that P.gingivalis, B.forsythus, C.rectus, A.actinomycetemcomitans and P.intermedia might be able to be use as risk markers for onset of periodontitis in adolescent students.4. Both of detection of these specific periodontal pathogens and measuring IgG antibody titer against these bacteria might be useful for screening method for students with periodontitis.5. In Japanese, tandem repeat (VNTR) polymorphisms in IL-1 receptor antagonist gene and vitamin D receptor (VDR)/FcRIIIb genotype combination were associated with generalized EOP. Further, FcγRIIb gene polymorphisms associated with susceptibility of chronic periodontitis.6. The immunoreactive domain (IVTVPENGK) in 40-kDa outer membrane protein (40k-OMP) and 200-kDa antigenic protein from P.gingivalis were thought to have a potential use in a component vaccine against periodontitis. Further, 40k-OMP might be useful as a nasal vaccine for prevention of periodontitis. On the other hand, a newly constructed antibody against 130-kDa hemagglutinin domain may prove to be useful for development of passive immunization against periodontitis.7. The virulence factors (cytolethal distending toxin and capsular polysaccharide) from A.actinomycetemcomitans and a protection mechanism against infection of A.actinomycetemcomitans were clarified.8. The school dental health examination was performed in adolescent students, and the data on periodontal condition was accumulated.

为建立青少年学生牙周炎的预防体系，本研究对青少年学生牙周炎进行了为期3年（2001-2003年）的调查研究，主要结果如下：1.该研究项目的流行病学研究表明，青少年学生的牙周状况随着年龄的增长而恶化。2.在学校口腔健康检查中对牙周炎高危部位的筛查可能有助于这些学生牙周状况的改善.提示牙龈卟啉单胞菌、B、直链梭菌、伴放线菌和中间卟啉单胞菌可作为青少年牙周炎发病的危险标志物.检测这些牙周特异性病原菌和检测其IgG抗体滴度可作为学生牙周炎的筛查方法.在日本，IL-1受体拮抗剂基因串联重复序列（VNTR）多态性和维生素D受体（VDR）/FcRIIIb基因型组合与全身性EOP相关。此外，FcγRIIb基因多态性与慢性牙周炎易感性相关.牙龈卟啉单胞菌40 k-OMP和200 kDa抗原蛋白的免疫反应域（IVTVPENGK）被认为在牙周炎的组分疫苗中具有潜在的用途。此外，40 k-OMP可能是有用的作为预防牙周炎的鼻疫苗。另一方面，新构建的抗130-kDa血凝素结构域的抗体可能被证明是有用的发展被动免疫牙周炎。阐明了伴放线菌的毒力因子（细胞致死膨胀毒素和荚膜多糖）及其对伴放线菌感染的保护机制.对在校青少年学生进行口腔健康检查，积累牙周状况资料。