Variation and ageing pattern of free steroid hormone levels among Japanese

日本人游离类固醇激素水平的变化和衰老模式

• 批准号: 13640714
• 负责人: UCHIDA Akiko
• 金额: $ 2.56万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13640714/
• 关键词: steroid hormone; Japanese; variation; ageing; cognition; 遊離型ステロイド; 人類学

Salivary testosterone levels were analyzed for 15-90 year-old-Japanese in order to understand the variability and ageing patterns. Findings are as follows :1) The variation in salivary free testosterone levels (T) among Japanese for the both sexes is significant.2) The aging pattern in T among Japanese males is different from those of hunter-gatherers in showing a significant decrease from 20s to 40s. But it is also different from those of western industrialized countries in not showing any significant decrease after 40 years old.3) Decrease in diurnal fluctuation which has been know to be common among old men in the western countries was not significant among Japanese males. There are many 60-70 year-old males who show significant diurnal T-fluctuation. Probably they maintain healthy neuro-endocrinological systems.4) There is no clear association found between mental rotation scores and free testosterone levels for both sexes, except that males with extremely low testosterone levels scored high.5) There is a positive association between Mini-Mental-State and free T in 90-year-old males.

唾液睾酮水平进行了分析，为15-90岁的日本人，以了解变异性和老化模式。结果表明：（1）日本男性和女性唾液游离睾酮水平（T）的差异显著;（2）日本男性T的衰老模式与狩猎采集者不同，从20岁到40岁显著下降。但与西方工业化国家不同的是，40岁以后没有明显的减少。3）在西方国家的老年人中，昼夜波动的减少是普遍现象，但在日本男性中，昼夜波动的减少并不明显。有许多60-70岁的男性表现出明显的昼夜T波动。4）男性和女性的心理旋转得分与游离睾酮水平之间没有明显的相关性，只有极低睾酮水平的男性得分较高。5）90岁男性的迷你心理状态与游离睾酮水平呈正相关。

项目成果

Uchida, A., Bribiescas, R., Kanamori, M., Hirose, N., Ando, J., and Ohno, Y.: "Salivary testosterone levels in healthy 90-year-old Japanese males : Implications for endocrine senescence"International Society of Human Ethology Bulletin. 17/3. 40 (2002)

Uchida, A.、Bribiescas, R.、Kanamori, M.、Hirose, N.、Ando, J. 和 Ohno, Y.：“健康 90 岁日本男性的唾液睾酮水平：对内分泌衰老的影响”

Uchida, A, Bilbiescas, R., Kanamori, M., Hirose, N., Ando, J., Ohno, Y.: "Salivary testosterone levels in healthy 90-year-old Japanese males : Implications for endocrine senescence"International Society of Human Ethology Bulletin. 17・3. 40 (2002)

Uchida, A、Bilbiescas, R.、Kanamori, M.、Hirose, N.、Ando, J.、Ohno, Y.：“健康 90 岁日本男性的唾液睾酮水平：对内分泌衰老的影响”国际人类行为学协会公报 17・3（2002）。

Uchida, A, Bribiescas, R., Kanamori, M., Hirose, N., Ando, J., Ohno, Y.: "Salivary testosterone levels in healthy 90-year-old Japanese males : Implications for endocrine senescence"International Society of Human Ethology Bulletin. 17・3. 40 (2002)

Uchida, A、Bribiescas, R.、Kanamori, M.、Hirose, N.、Ando, J.、Ohno, Y.：“健康 90 岁日本男性的唾液睾酮水平：对内分泌衰老的影响”国际人类行为学协会公报 17・3（2002）。