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Optimal serum total cholesterol level for life expectancy and for active-life expectancy in the Japanese elderly

日本老年人预期寿命和积极预期寿命的最佳血清总胆固醇水平

基本信息

批准号：
13670409
负责人：
WATANABE Shuichiro
金额：
$ 1.86万
依托单位：
OBIRIN UNIVERSITY (2002-2003)Tokyo Metropolitan Institute of Gerontology (2001)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

The association of serum total cholesterol concentration (TC) with all-cause mortality and with decline in functional capacity was investigated in the Japanese elderly. In 454 men and 632 women aged 65 years and over at baseline who were ambulatory, TC was measured Mortality risk during 6 years of follow-up was calculated using a proportional hazards model, adjusted for region, age, serum albumin, sistolic blood pressure, body mass index, and smoking. Of 1086 subjects, 23 who took a medicine for hyperlipidemia, and 13 who died within a year were excluded from the analysis. During the 6-year follow-up, 22.4% of men and 12.1% of warren died. TC for the young-old (66-74 years) elderly had a U-shaped relationship with mortality in both sexes. For the young-old, low TC (lowest quartile, <4.0 mmol/L for men (relative hazard (RH)=3.3), <4.7 mmol/L for women (RH=2.3)) was significant mortality risk, and high TC (highest quartile, >5.4 mmol/L for men (RH=3.3)) was also significant mortality risk for men. Lowest relative hazard in the young-old was at TC between 4.0 and 4.7 mmol/L for women, and between 4.7 and 5.3 mmol/L for women. While for the old-old (75 years and over) elderly, TC was not associated with mortality for men, furthermore, among women, a significant inverse association was found. Lowest relative hazard in the old-old women was at TC 6.0 mmol/L and over (highest quartile). The optimal TC for the old-old elderly appears to be different from that for the young-old elderly. TC was not associated with decline in functional capacity.

在日本老年人中研究了血清总胆固醇浓度（TC）与全因死亡率和功能能力下降的关系。在基线时年龄在65岁及以上的454名男性和632名女性中，测量TC。使用比例风险模型计算6年随访期间的死亡风险，校正地区，年龄，血清白蛋白，血压，体重指数和吸烟。在1086名受试者中，23名服用高脂血症药物的受试者和13名在一年内死亡的受试者被排除在分析之外。在6年的随访中，22.4%的男性和12.1%的沃伦人死亡。66-74岁老年人TC与死亡率呈U型关系。对于10岁的老年人，低TC（最低四分位数，男性<4.0 mmol/L（相对危险度（RH）=3.3），女性<4.7 mmol/L（RH=2.3））是显著的死亡风险，高TC（最高四分位数，男性>5.4 mmol/L（RH=3.3））也是显著的死亡风险。在10岁以下的女性中，TC在4.0和4.7 mmol/L之间的相对危险性最低，女性在4.7和5.3 mmol/L之间。而对于老年（75岁及以上）男性，TC与死亡率无相关性，女性TC与死亡率呈显著负相关，老年女性TC 6.0 mmol/L及以上（最高四分位数）的相对危险性最低。高龄老人和高龄老人的最佳TC似乎不同。TC与功能能力下降无关。