A study on autoantibodies to killer immunoglobulin-like receptors and hyper-gamma-globulinemia in systemic autoimmune diseases

我们一直在研究所谓的抗淋巴细胞抗体，针对淋巴细胞表面分子的抗体。在本研究中，我们试图检测和分析NK受体之一的杀伤免疫球蛋白样受体2dl的自身抗体。我们在此证明了类风湿性关节炎、系统性红斑狼疮和白塞氏病中存在KIR2DL自身抗体，其存在与高γ -球蛋白血症相关。为了进一步分析其机制，我们研究了KIR2DL自身抗体对NK细胞抗细胞毒活性的影响，然而，检测到的效果在血清样本之间是不同的。需要进一步进行更详细的分析以阐明这些机制。

We have been investigating so-called anti-lymphocyte antibodies, antibodies to cell surface molecules on the lymphocytes. In the present study, we tried to detect and analyze autoantibodies to killer immunoglobulin-like receptor 2 DL, one of the NK receptors. We here evidenced existence of autoantibodies to KIR2DL in rheumatoid arthritis, systemic lupus erythematosus, and Behcet's disease, where the existence was correlated with hyper-gamma-globulinemia. To further analyze mechanisms for this, we investigated the effects of the KIR2DL autoantibodies on the anti-cytotoxic activity of NK cells, however, the detected effects were different between the serum samples. Further more detailed analysis would be needed to elucidate the mechanisms.