Studies on the role of annexin7 in the pathophysiology and therapies of rheumatoid arthritis using proteomics

类风湿性关节炎（RA）是一种累及多个关节的慢性炎症性疾病。除生物制剂外，还应建立新的治疗方法。我们通过蛋白质组学方法鉴定了一种新的RA相关蛋白annexin 7，证明了annexin 7的关节致炎性及其作为治疗靶点的作用。此外，我们证明膜联蛋白7通过IL-8促进关节炎。本研究为RA的治疗提供了新的思路。

Rheumatoid arthritis (RA) is a chronic inflammatory disease, involving multiple joints. In addition to the biologics, novel therapies should be established. We identified a novel RA-related protein of annexin 7 by proteomics, evidenced arthritogenecity of annexin7 and its role as a therapeutic target suing transgenic mice. Further, we evidenced annexin 7 contributed to arthritis through IL-8. Our study would be useful to establish a new therapy for RA.