Specification of the factor in a liver cell required for multiplication of hepatitis C virus
Specification of the factor in a liver cell required for multiplication of hepatitis C virus
批准号:
13670521
负责人:
CHAYAMA Kazuaki
金额:
$1.92万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2003
中文摘要
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英文摘要
Hepatitis C virus infection is a serious health problem worldwide. As the hepatitis C virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a full length genotype 1b cDNA clone of the hepatitis C virus from a patient who developed acute hepatitis C. This cDNA clone was used to construct several replicon clones and infectious clones. These constructs should be useful to study the hepatitis C virus.
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S.Tazuma, T.Nishioka, Chayama K et al.: "Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy"J Gastroenterol Hepatol. 18(2). 157-161 (2003)
S.Tazuma、T.Nishioka、Chayama K 等人:“老年胆结石患者胆囊粘膜功能受损可抑制体外冲击波碎石术成功后胆结石复发”J Gastroenterol Hepatol。
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K.Tsuboi, S.Tazuma, H.Ochi, Chayama K.: "Hydrophilic bile salts have a cyclosporine A-induce cholestasis through enhanced canalicular membrane fluidity and transporter activity"Hepatol Res. 25(1). 38-47 (2003)
K.Tsuboi、S.Tazuma、H.Ochi、Chayama K.:“亲水性胆汁盐具有环孢菌素 A-通过增强小管膜流动性和转运蛋白活性诱导胆汁淤积”Hepatol Res。
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W.Ohishi, M.Kitamoto, Chayama K.ほか7名: "Impact of aging on the development of hepatocellular carcinoma in patients with hepatitis C virus infection in japan."Scand J Gastroenterol. 38,8. 894-900 (2003)
W.Ohishi、M.Kitamoto、Chayama K. 和其他 7 人:“日本丙型肝炎病毒感染患者中衰老对肝细胞癌发展的影响”,Scand J Gastroenterol 38,8 (2003)。
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K.Nakai, S.Tazuma, T.Nishioka, Chayama K.: "Inhibiton of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation."Biochim Biophys Acta. 1632,1-3. 48-54 (20
K.Nakai、S.Tazuma、T.Nishioka、Chayama K.:“胆红素解离作用下胆固醇结晶的抑制:感染胆汁加速色素结石形成机制的部分表征。”Biochim Biophys Acta。
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Waka Ohishi, K.Chayama: "Rare Quasispecies in the YMDD motif of Hepatitis B Virus Detected by Polymerase Chain Reaction with Peptitde Nucleic Acid Clamping"Intervirology. 46・6. 355-361 (2003)
Waka Ohishi,K.Chayama:“通过肽核酸钳位的聚合酶链反应检测乙型肝炎病毒 YMDD 基序中的稀有准种”Intervirology 46・6 (2003)。
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共 52 条
Identification of SNPs on mature micro RNA to analyze origin of miRNA
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批准号:25670369
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2013
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负责人:CHAYAMA Kazuaki
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依托单位:
Analysis of unknown pathogen using human hepatocyte chimeric mouseand massive parallel sequencing
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批准号:24659368
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:CHAYAMA Kazuaki
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依托单位:
Generation of a mouse model that shows specific features of human diseases.
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批准号:22659147
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.07万
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财政年份:2010
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负责人:CHAYAMA Kazuaki
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依托单位:
A comprehensive transcriptome analysis of humanized mouse liver using ultra high density cDNA micro array
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批准号:21390229
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
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财政年份:2009
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负责人:CHAYAMA Kazuaki
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依托单位:
Production of interferon stimulated gene library and screening of new therapeutic drug for hepatitis viruses
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批准号:18390218
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.35万
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财政年份:2006
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负责人:CHAYAMA Kazuaki
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依托单位:
Analysis of lamivudine resistance acquisition by hepatitis B virus.
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批准号:13557049
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.32万
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财政年份:2001
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负责人:CHAYAMA Kazuaki
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依托单位:
Detection of drug resistant mutant hepatitis B virus strain and its clinical application.
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批准号:10670524
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1998
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负责人:CHAYAMA Kazuaki
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依托单位:
Interferon resistance of hepatitis C virus
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批准号:06670595
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.26万
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财政年份:1994
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负责人:CHAYAMA Kazuaki
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依托单位:
海外基金