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Specification of the factor in a liver cell required for multiplication of hepatitis C virus

Specification of the factor in a liver cell required for multiplication of hepatitis C virus
丙型肝炎病毒增殖所需的肝细胞因子的规格
批准号:
13670521
负责人:
CHAYAMA Kazuaki
金额:
$1.92万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2003

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中文摘要
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英文摘要
Hepatitis C virus infection is a serious health problem worldwide. As the hepatitis C virus infects only humans and chimpanzees, establishment of reliable culture system is necessary to study this important pathogen. We cloned a full length genotype 1b cDNA clone of the hepatitis C virus from a patient who developed acute hepatitis C. This cDNA clone was used to construct several replicon clones and infectious clones. These constructs should be useful to study the hepatitis C virus.
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会议论文
S.Tazuma, T.Nishioka, Chayama K et al.: "Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy"J Gastroenterol Hepatol. 18(2). 157-161 (2003)
S.Tazuma、T.Nishioka、Chayama K 等人:“老年胆结石患者胆囊粘膜功能受损可抑制体外冲击波碎石术成功后胆结石复发”J Gastroenterol Hepatol。
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通讯作者:
K.Tsuboi, S.Tazuma, H.Ochi, Chayama K.: "Hydrophilic bile salts have a cyclosporine A-induce cholestasis through enhanced canalicular membrane fluidity and transporter activity"Hepatol Res. 25(1). 38-47 (2003)
K.Tsuboi、S.Tazuma、H.Ochi、Chayama K.:“亲水性胆汁盐具有环孢菌素 A-通过增强小管膜流动性和转运蛋白活性诱导胆汁淤积”Hepatol Res。
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通讯作者:
W.Ohishi, M.Kitamoto, Chayama K.ほか7名: "Impact of aging on the development of hepatocellular carcinoma in patients with hepatitis C virus infection in japan."Scand J Gastroenterol. 38,8. 894-900 (2003)
W.Ohishi、M.Kitamoto、Chayama K. 和其他 7 人:“日本丙型肝炎病毒感染患者中衰老对肝细胞癌发展的影响”,Scand J Gastroenterol 38,8 (2003)。
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通讯作者:
K.Nakai, S.Tazuma, T.Nishioka, Chayama K.: "Inhibiton of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation."Biochim Biophys Acta. 1632,1-3. 48-54 (20
K.Nakai、S.Tazuma、T.Nishioka、Chayama K.:“胆红素解离作用下胆固醇结晶的抑制:感染胆汁加速色素结石形成机制的部分表征。”Biochim Biophys Acta。
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52
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    • 财政年份:
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      $11.73万
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      2009
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    • 依托单位:
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