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Peripheral blood markers in the diagnosis of Alzheimer' s disease

外周血标志物在阿尔茨海默病诊断中的应用

基本信息

批准号：
13670628
负责人：
ARAI Hiroyuki
金额：
$ 2.05万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

Fasting plasma homocysteine (pHcy) levels in 141 patients with clinical diagnosis of Alzheimer' s disease (AD, 72.5±7.6 years) were compared with those in 139 age-matched community-dwelling normal control subjects (normal control, 75.3±5.1 years). When AD was grouped into 2 subgroups according to the presence or absence of co-existing silent brain infarction (SBI) on magnetic resonance imaging. the pHcy levels in the subgroup with SBI (14.0±4.5 μmol/L) were significantly elevated (o<0.0001) compared to the other subgroup without SBI (11.5±4.4 μmol) and the normal control group (11.0±3.0 μmol/L). After adjusting for age, multiple regression model demonstrated that high pHcy levels>11.4 μmol/L were associated with an increased risk for developing SBI in AD (odds ratio 4.2, 95% C. I. 1.7-10.5, o=0.002). Other vascular risk factors such as gender. ApoE4 gene, hypertension, current smoking, and serum cholesterol levels did not have a significant effect on SBI. The pHcy levels did not differ significantly according to the severity of deep white matter lesions among AD patients. Notably, either age at onset, cognitive function, cerebrospinal fluid tau or amyloid β-peptide1-42 levels did not significantly correlate with pHcy levels in AD. Our results suggest that homocysteine may not confer a direct risk for AD but relates to co-existing SBI, a unique vascular condition that occurs independently of other vascular risks.

本文对141例临床诊断为阿尔茨海默病（AD，72. 5 ± 7. 6岁）患者和139例年龄匹配的社区健康对照者（正常对照组，75. 3 ± 5. 1岁）的空腹血浆同型半胱氨酸（pHcy）水平进行了比较。根据磁共振成像上是否存在共存的无症状性脑梗死（SBI），将AD分为2个亚组。SBI组pHcy水平（14.0±4.5 μmol/L）显著高于非SBI组（11.5±4.4 μmol/L）和正常对照组（11.0±3.0 μmol/L）（p <0.0001）。经年龄校正后，多元回归模型显示，高pHcy水平>11.4 μmol/L与AD患者发生SBI的风险增加相关（OR 4.2，95%C. I. 1.7-10.5，0 =0.002）。其他血管风险因素，如性别。ApoE 4基因、高血压、吸烟和血清胆固醇水平对SBI无显著影响。根据AD患者深部白色病变的严重程度，pHcy水平没有显著差异。值得注意的是，无论是发病年龄，认知功能，脑脊液tau蛋白或淀粉样β-肽1 -42水平与AD中的pHcy水平没有显著相关性。我们的研究结果表明，同型半胱氨酸可能不会赋予AD的直接风险，但涉及到共存的SBI，一个独特的血管条件，发生独立于其他血管风险。