Physiological significance of phosphatidylinositol (PI) molecular species in PI signaling
Physiological significance of phosphatidylinositol (PI) molecular species in PI signaling
批准号:
20370045
负责人:
ARAI Hiroyuki
金额:
$13.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The fatty acid composition of phosphatidylinositol (PI) is unique in that most of PI fraction in mammalian tissues and cells constitutes the 1-stearoyl-2-arachidonoyl species. In this study, we identified acyltransferases, named LYCAT/ACL-10 and LPIAT1/MBOA-7,that incorporate stearic acid and arachidonic acid into lysoPI, respectively. Furthermore, we revealed the physiological significance of unique molecular species in PI by generating knockout worms and mice of these enzymes.
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DOI:
10.1371/journal.pgen.1001055
发表时间:
2010-08-01
期刊:
PLOS GENETICS
影响因子:
4.5
作者:
[Kobuna, Hiroyuki, Inoue, Takao, Arai, Hiroyuki]
通讯作者:
Arai, Hiroyuki
DOI:
10.1038/emboj.2008.102
发表时间:
2008-06-18
期刊:
EMBO JOURNAL
影响因子:
11.4
作者:
[Kanamori, Takahiro, Inoue, Takao, Arai, Hiroyuki]
通讯作者:
Arai, Hiroyuki
C.elegans as a model for studying the biological functions of polyunsaturated fatty acyl chain in membrane phospholipids
线虫作为研究膜磷脂中多不饱和脂肪酰基链生物学功能的模型
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[T.Shima, K.Sutoh, T.Kon, 松田真治, 松田真治, 松田真治, 松田真治, 松田真治, 松田真治]
通讯作者:
松田真治
リン脂質アシルトランスフェラーゼの包括的解析
磷脂酰基转移酶的综合分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Matsumoto, M., H.Oshiumi, T.Seya., 井上貴雄]
通讯作者:
井上貴雄
Identification of enzymes involved in fatty acid remodeling of phosphatidylinositol
参与磷脂酰肌醇脂肪酸重塑的酶的鉴定
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[D. Tokuhara, B. Gonzalez, M. Mejima, Y. Takahashi, S. Kurokawa, T. Hiroiwa, M. Kuroda, M. Oyama, H. Kozuka-Hata, T. Nochi, F. Aladin, H. Marcotte, L. Frenken, M. Iturriza, H. Kiyono, L. Hammarstrom, & Y. Yuki, 井上貴雄]
通讯作者:
井上貴雄
共 40 条
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Effect of Kampo medicine on cognition and behavior of Alzheimer's disease patinas.
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Real-time DOA Estimation System by DBF Array Antenna and Its Applications
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Physiological and pathological functions of a novel lipid-binding protein family.
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Clinical trials of anti-dementia drugs and biological markers
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Production and application of novel model animals with an oxidative stress
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Early diagnostic marker for Alzheimer's disease
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Molecular Mechanism of Vitamine E recycling in vivo.
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负责人:ARAI Hiroyuki
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海外基金