权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effect of Kampo medicine on cognition and behavior of Alzheimer's disease patinas.

汉方药物对阿尔茨海默病铜绿认知和行为的影响。

基本信息

批准号：
16590554
负责人：
ARAI Hiroyuki
金额：
$ 2.43万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590554/
关键词：
Alzheimer's disease cognitive function complementary and alternative medicine Dementia with Lewy bodies Kampo medicine Integrated medicine Donepezil cerebral blood flow 認知症漢方薬ランダム化比較研究 MMSE Barthel Index 痴呆症二重盲験ランダム化比較試験

项目摘要

In this study, we showed 3 major findings (evidenced based medicine) regarding complementary and alternative medicine of Kampo medicine1.A combinatorial use of donepezil and kami-untan-to(Japanese herbal medicine) was found to be more beneficial than each drug alone. An increase in cerebral blood flow also was observed only in the patients who received both donepezil and kami-untan-to. These results may provide a new evidence for integrated medicine of Western/complementary and alternative medicine.2.A randomized, placebo-controlled, double blind clinical trial showed that 8 week treatment by Ba-wei-di-huang wan, a traditional Chinese medicine, wan was found to improve not only cognitive function, but also physical activity in Alzheimer's patients. No serious adverse events were found following use of Ba-wei-di-huang.3.No reliable therapy was known to be beneficial in dementia with Lewy bodies. A observer-blind controlled study showed that Yi-Gan-San, a traditional Chinese medicine, was found to be beneficial in reducing severity and frequency of behavioral and psychological symptoms of dementia such as visual hallucination, delusion and emotional irritability. Notably, it is most notable that visual hallucination associated with dementia with Lewy bodies declined dramatically without producing neuroleptic supersensitivity. Yi-Gan-San improve not only cognitive functions.

在这项研究中，我们展示了3个主要发现（基于证据的医学）关于汉方医学的补充和替代医学1.多奈哌齐和kami-untan-to（日本草药）的组合使用被发现比单独使用每种药物更有益。仅在接受多奈哌齐和kami-untan-to的患者中观察到脑血流量增加。2.随机、安慰剂对照、双盲临床试验表明，中药八味地黄丸治疗8周，不仅能改善阿尔茨海默病患者的认知功能，而且能改善患者的体力活动。应用八味地黄后未发现严重不良反应。3.目前尚无可靠的治疗路易体痴呆的有效方法。一项双盲对照研究表明，中药益肝散有助于减轻痴呆的行为和精神症状，如幻视、妄想和情绪烦躁的严重程度和频率。值得注意的是，最值得注意的是，与路易体痴呆症相关的幻视急剧下降，而不会产生神经安定药的超敏反应。益肝散不仅改善认知功能。

项目成果

期刊论文数量（74）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Caregiver's burden and use of public services among dementia caregivers.

痴呆症护理人员的护理负担和公共服务的使用。

DOI：
发表时间：
2005
期刊：
Geriatr.Gerontol.Internat. (In Press)
影响因子：
0
作者：
Tanji H;Ootsuki M;Matsui T;Maruyama M;Nemoto M;Tomita N;Seki T;Iwasaki K;Arai H;Sasaki H.
通讯作者：
Sasaki H.

Effect of Kami-Untan-To on the impairment of leaning nd memory induced by thiamine-deficient feeding in mice.

Kami-Untan-To 对硫胺素缺乏喂养引起的小鼠学习和记忆障碍的影响。