Evaluation of intraportal venous flow distribution by unenhanced MR angiography using tagging pulse

使用标记脉冲通过非增强磁共振血管造影评估门静脉内血流分布

• 批准号: 13670943
• 负责人: ITO Katsuyoshi
• 金额: $ 1.54万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670943/
• 关键词: Superior mesenteric venous flow; Splenic venous flow; Hepatic cirrhosis; Portal venous flow distribution; Unenhanced MR angiography; Tagging pulse; MRI; 門脈血流

Portal flow imaging using unenhanced MR angiography techniques was performed for normal subjects to evaluate the intraportal venous flow distribution from the superior mesenteric vein and the splenic vein. At first, unenhanced MR angiographic images without using tagging pulse were obtained as referenced images of the portal vein. In these images, the portal vein is shown as high signal intensity. Then, tagging pulse was placed on the superior mesenteric vein to suppress the inflow signal from the superior mesenteric vein. As a result, the superior mesenteric venous inflow is demonstrated as areas of decreased signal in the portal vein. The same technique was applied to the splenic vein. In this study, we showed that the superior mesenteric venous flow mainly entered into the right side of the main portal vein forming the streamlined flow while the splenic venous flow mainly entered into the left side of the main portal vein in the normal subjects.As the next analysis, we evaluated the … More influence of fasting and food intake for the portal flow dynamics. In this study, we revealed that the portal vein was predominantly perfused by the splenic venous flow before meal while it was predominantly perfused by the superior mesenteric venous flow after meal. Additionally, the superior mesenteric venous flow dramatically increased after meal compared with the fasting state while the splenic venous flow decreased in 41%, increased in 31% and showed no change in 28% of the subjects.In clinical study, we evaluated the pattern of the intraportal venous flow distribution in cirrhotic patients. In cirrhotic patients, we sometimes observed the superior mesenteric venous flow entering into the left side of the main portal vein and the splenic venous flow entering into the right side of the main portal vein forming the streamlined flow. Additionally, the reversed flow from the superior mesenteric vein into the splenic vein can be observed in cirrhotic patients. These facts indicate that portal venous flow dynamics in cirrhotic patients may be different from that in normal subjects. Less

采用非增强磁共振血管造影技术对正常人进行门静脉血流成像，以评估肠系膜上静脉和脾静脉门静脉血流分布。首先，获得不使用标记脉冲的未增强MR血管成像图像作为门静脉的参考图像。在这些图像中，门静脉显示为高信号。然后将标记脉冲置于肠系膜上静脉，抑制肠系膜上静脉的流入信号。因此，肠系膜上静脉流入表现为门静脉信号减弱的区域。同样的技术应用于脾静脉。在本研究中，我们发现肠系膜上静脉流主要进入门静脉主静脉右侧形成流线型流，而正常人脾静脉流主要进入门静脉主静脉左侧。在接下来的分析中，我们评估了禁食和食物摄入对门静脉血流动力学的影响。在这项研究中，我们发现餐前门静脉主要由脾静脉血流灌注，而餐后门静脉主要由肠系膜上静脉血流灌注。与空腹相比，餐后肠系膜上静脉流量显著增加，而脾脏静脉流量减少的占41%，增加的占31%，没有变化的占28%。在临床研究中，我们评估了肝硬化患者门静脉血流分布的模式。在肝硬化患者中，我们有时观察到肠系膜上静脉流进入门静脉主干左侧，脾静脉流进入门静脉主干右侧，形成流线型血流。此外，在肝硬化患者中可以观察到从肠系膜上静脉到脾静脉的反向流动。这些事实表明肝硬化患者的门静脉血流动力学可能与正常人不同。少

项目成果

Ito K: "Intraportal venous flow distribution: evaluation with single breath-hold ECG-triggered three-Dimensional half-Fourier Fast spin-echo MR imaging"AJR. 178. 343-348 (2002)

Ito K：“门静脉内血流分布：用单次屏气心电图触发的三维半傅立叶快速自旋回波 MR 成像进行评估”AJR。

Katsuyoshi Ito: "Evaluation of intraportal venous flow distribution by unenhanced MR angiography using 3D FSE sequence with a selective IR tagging pulse"Radiology. vol.225. 226-226 (2002)

Katsuyoshi Ito：“使用 3D FSE 序列和选择性 IR 标记脉冲，通过非增强 MR 血管造影评估门静脉内血流分布”放射学。

伊東克能: "3D FASE法による門脈血流分布の評価:呼吸停止下tag on-off modeによるsubtraction画像の有用性"日本医学放射線学会雑誌. 62. 222-222 (2002)

Katsuno Ito：“使用 3D FASE 方法评估门脉血流分布：呼吸停止时使用标签开关模式的减影图像的有用性”日本医学放射学会杂志 62. 222-222 (2002)。

Katsuyoshi Ito: "Evaluation of intraportal venous flow distribution by 3D FASE sequence: value of subtraction images obtained with tag on-off mode during a single breathhold"Nippon Acta Radiologica. vol.62. 222-222 (2002)

Katsuyoshi Ito：“通过 3D FASE 序列评估门静脉内血流分布：在单次屏气期间使用标签开关模式获得的减影图像的值”Nippon Acta Radiologica。

Katsuyoshi Ito: "Portal venous flow: evaluation with a single breathhold ECG-triggered 3D falf-fourier FSE MR imaging with a selective inversion recovery tagging pulse"Cardiovascular & Interventional Radiology. vol.24. 146-146 (2001)

Katsuyoshi Ito：“门静脉流量：使用单次屏气 ECG 触发的 3D 法尔夫傅立叶 FSE MR 成像和选择性反转恢复标记脉冲进行评估”心血管