Evaluation of Lacrimal Gland Function in Sjogren Syndrome with Dynamic MR Dacryocystography after Injection of Antirex

注射Antirex后动态MR泪囊造影评价干燥综合征泪腺功能

• 批准号: 13670970
• 负责人: TONAMI Hisao
• 金额: $ 0.32万
• 依托单位: KANAZAWA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670970/
• 关键词: Dynamic MRI; Fast imaging; Dacryocystography; Antirex; Sjogren syndrome; Lacrimal gland function

This study was conducted to assess the utility of dynamic MR dacryocystography in the evaluation of the behavior of the lacrimal gland duct after injection of Antirex (edrophonium chloride), and to estimate the lacrimal gland function in patients with Sjogren syndrome. Dynamic MR dacryocystography was obtained using a single-shot RARE sequence with a 4-cm-diameter surface coil. Imaging parameters were : echo spacing=11.5 msec, effective TE=1100 msec, ETL=240, slab thickness=30 mm, FOV=169X169 mm, image matrix=240X256, in-plane resolution=0.70X0.66 mm, NEX=1, acquisition time=7.1 sec. Immediately after intravenous injection of Antirex, sequential MR dacryocystograms were obtained. Eight control subjects and 48 patients suspected of having Sjogren syndrome with symptoms of dry eye were included in this study. Labial gland biopsy and Schirmer's test were performed in all patients. Morphologic and functional evaluation of dynamic MR dacryocystography was performed and comparative study with the results of labial gland biopsy and Schirmer's test was done. In control subjects, the lacrimal sac was seen soon after the injection of Antirex, thereafter the nasolacrimal duct was gradually demonstrated. In patients suspected of having Sjogren syndrome, delayed or lack visualization of lacrimal sac and nasolacrimal duct was seen on dynamic MR dacryocystography. Significant correlation was present between the results of dynamic MR dacryocystography and Schirmer's test (p<.001). Also there was correlation between the results of dynamic MR dacryocystography and labial gland biopsy (p<.01). We conclude that dynamic MR dacryocystography after injection of Antirex provides detailed, physiologic information about the conditions of lacrimal gland in patients with Sjogren syndrome.

本研究旨在评估动态 MR 泪囊造影在评估注射 Antirex（依酚氯铵）后泪腺管行为的效用，并评估干燥综合征患者的泪腺功能。使用带有 4 厘米直径表面线圈的单次 RARE 序列获得动态 MR 泪囊造影。成像参数为：回波间隔=11.5毫秒，有效TE=1100毫秒，ETL=240，平板厚度=30毫米，FOV=169X169毫米，图像矩阵=240X256，面内分辨率=0.70X0.66毫米，NEX=1，采集时间=7.1秒。静脉注射 Antirex 后立即获得连续 MR 泪囊图。本研究包括 8 名对照受试者和 48 名疑似患有干燥综合征并伴有干眼症状的患者。所有患者均进行唇腺活检和席默试验。进行动态MR泪囊造影的形态学和功能评价，并与唇腺活检和Schirmer试验的结果进行比较研究。在对照受试者中，注射 Antirex 后不久即可看到泪囊，此后鼻泪管逐渐显现。在怀疑患有干燥综合征的患者中，动态 MR 泪囊造影显示泪囊和鼻泪管延迟或缺乏可视化。动态 MR 泪囊造影和 Schirmer 试验的结果之间存在显着相关性 (p<.001)。动态 MR 泪囊造影和唇腺活检结果之间也存在相关性 (p<.01)。我们的结论是，注射 Antirex 后进行动态 MR 泪囊造影可提供有关干燥综合征患者泪腺状况的详细生理信息。