Development of an imaging system to determine the three-dimensional structure of arteries using synchrotron radiation monochromatic X-rays

开发利用同步辐射单色X射线确定动脉三维结构的成像系统

• 批准号: 13670975
• 负责人: HYODO Kazuyuki
• 金额: $ 1.98万
• 依托单位: HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATION
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670975/
• 关键词: Synchrotron Radiation; X-ray Optics; Coronary Angiography; Laue Crystal; Monochromnatic X-ray; stereo-imaging; Micro-angiography; 立体情報; 心血管系; ステレオペア

In comparison with the conventional radiography, drastic improvement in spatial resolution and density resolution on the X-ray image are expected, imaging systems for the purpose of the diagnosis of cardiovascular system, cancers, metabolism in the brain, bones fine structure, etc. using synchrotron radiation monochromatic X-rays are developing in synchrotron radiation facilities in the world. In those systems, the irradiation direction of monochromatic X-rays to an object will be limited by characteristics of generating synchrotron radiation beam from an accelerator. Therefore, there is a case in which it becomes a problem, when the overlap of arterial system and soft tissue makes an X-ray projection image. It seems to be very useful to obtain information of the three-dimensional structure of cardiovascular system in case of angiography using synchrotron radiation.The purpose of this study is the development of method for reducing the overlap of the cardiovascular system on the X-ray projection image by using a Laue crystal (1) or rotating an object at very low speed (2). Preliminary experiments on stereo-imaging were performed to determine the three-dimensional structure of coronary arteries for intravenous coronary angiography and also micro-angiography using synchrotron radiation produced by a bending magnet at the PF-AR, KEK and also a vertical wiggler at the PF, KEK. The possibility of these two methods was confirmed. It is expected that the result can be applied to the other imaging methods including the new imaging method using X-ray refraction.

与传统的放射线照相术相比，期望X射线图像的空间分辨率和密度分辨率的显著提高，在世界上的同步辐射设备中正在开发用于诊断心血管系统、癌症、脑中的代谢、骨骼精细结构等的成像系统，该成像系统使用同步辐射单色X射线。在这些系统中，单色X射线对物体的照射方向将受到加速器产生同步辐射束的特性的限制。因此，当动脉系统和软组织的重叠形成X射线投影图像时，存在成为问题的情况。在同步辐射血管造影术中，获得心血管系统的三维结构信息是非常有用的，本研究的目的是开发一种方法，通过使用劳厄晶体（1）或以很低的速度旋转物体（2）来减少心血管系统在X射线投影图像上的重叠。对立体成像进行了初步实验，以确定冠状动脉的三维结构，用于静脉内冠状动脉造影术和微血管造影术，使用由PF-AR，KEK处的弯曲磁体和PF，KEK处的垂直摆动器产生的同步辐射。证实了这两种方法的可行性。这一结果可望应用于其它成像方法，包括利用X射线折射的新成像方法。

项目成果

S. Ohtsuka, I. Yamaguchi, J. Wu, T. Takeda, Y. Itai, A. Maruhashi, K. Hyodo and M. Ando: "Clinical application of synchrotron radiation to intravenous coronary angiography at PF-AR"Photon Factory Activity Report. 18. 43-44 (2001)

S. Ohtsuka、I. Yamaguchi、J. Wu、T. Takeda、Y. Itai、A. Maruhashi、K. Hyodo 和 M. Ando：“同步辐射在 PF-AR 静脉冠状动脉造影中的临床应用”光子工厂活动

N.Nariyama, et al.: "Comparison of In-phantom Dose Distributions for Coronary Angiography Using an X-ray and"Medical Physics. 28(1). 16-21 (2001)

N.Nariyama 等人：“使用 X 射线进行冠状动脉造影的体模剂量分布的比较”和医学物理学。

K. Hyodo and M. Ando: "Intravenous coronary angiography system using monochromatic synchrotron radiation X-rays"Journal of The Society of Photographic Science and Technology of Japan. 65(7) (in Japanese). 490-494 (2002)

K. Hyodo 和 M. Ando：“使用单色同步辐射 X 射线的静脉冠状动脉造影系统”日本摄影科学技术学会杂志。

K. Hvodo, M. Ando, S. Yamamoto, S. Ohtsuka, I. Yamaguchi, T. Takeda, and Y. Itai: "Development of the two-dimensional intravenous coronary angiography system II at the PF-AR NE1, KEK"Abstract of the 5th Harima International Forum. 30. (2001)

K. Hvodo、M. Ando、S. Yamamoto、S. Ohtsuka、I. Yamaguchi、T. Takeda 和 Y. Itai：“PF-AR NE1、KEK 二维静脉冠状动脉造影系统 II 的开发”

Kazuyuki HYODO: "Development of the two-dimensional intravenous coronary angiography system II at the PF-AR NE1, KEK"Abstract of the 5th Harima International Forum. 30 (2001)

Kazuyuki HYODO：“PF-AR NE1、KEK 二维静脉冠状动脉造影系统 II 的开发”第五届播磨国际论坛摘要。