Development and evaluation of imaging systems for the three-dimensional structure of arteries using synchrotron radiation monochromatic X-rays

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Synchrotron radiation, which is characterized by its high intensity, X-ray energy tunability and small X-ray beam divergence, is a very powerful tool for medical researches and many imaging systems using synchrotron radiation are under developing in synchrotron radiation facilities in the world. In those systems, the irradiation direction of monochromatic X-rays to an object is limited by characteristics of generating synchrotron radiation beam from an accelerator. Therefore, there is a case in which it becomes a problem, when the overlap of arterial system and soft tissues make an X-ray projection image. It seems to be very useful to obtain information of the three-dimensional structure of the target organ, especially in case of angiography using synchrotron radiation monochromatic X-rays. The purpose of this study is development and evaluation of the method for reducing the overlap of the cardiovascular system in an X-ray projection image by (1) rotating an object and (2) using a Laue crystal. Preliminary experiments on the stereo-imaging were performed to determine the three-dimensional structure of coronary arteries for intravenous coronary angiography and micro-angiography using synchrotron radiation produced by a bending magnet and a multi-pole wiggles beamlines at the PF-AR, KEK and a vertical wiggler beamline at the PF, KEK. The possibility of these two methods was confirmed by the phantom experiments. It is expected that the result can be applied to the other imaging methods using synchrotron radiation monochromatic X-rays including the diffraction enhancement imaging (DEI) method.