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Development and evaluation of imaging systems for the three-dimensional structure of arteries using synchrotron radiation monochromatic X-rays

使用同步辐射单色X射线的动脉三维结构成像系统的开发和评估

基本信息

批准号：
15591312
负责人：
HYODO Kazuyuki
金额：
$ 1.86万
依托单位：
HIGH ENERGY ACCELERATOR RESEARCH ORGANIZATION (2004)The High Energy Accelerator Research Organization (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

Synchrotron radiation, which is characterized by its high intensity, X-ray energy tunability and small X-ray beam divergence, is a very powerful tool for medical researches and many imaging systems using synchrotron radiation are under developing in synchrotron radiation facilities in the world. In those systems, the irradiation direction of monochromatic X-rays to an object is limited by characteristics of generating synchrotron radiation beam from an accelerator. Therefore, there is a case in which it becomes a problem, when the overlap of arterial system and soft tissues make an X-ray projection image. It seems to be very useful to obtain information of the three-dimensional structure of the target organ, especially in case of angiography using synchrotron radiation monochromatic X-rays. The purpose of this study is development and evaluation of the method for reducing the overlap of the cardiovascular system in an X-ray projection image by (1) rotating an object and (2) using a Laue crystal. Preliminary experiments on the stereo-imaging were performed to determine the three-dimensional structure of coronary arteries for intravenous coronary angiography and micro-angiography using synchrotron radiation produced by a bending magnet and a multi-pole wiggles beamlines at the PF-AR, KEK and a vertical wiggler beamline at the PF, KEK. The possibility of these two methods was confirmed by the phantom experiments. It is expected that the result can be applied to the other imaging methods using synchrotron radiation monochromatic X-rays including the diffraction enhancement imaging (DEI) method.

同步辐射具有高强度、x射线能量可调性和x射线束发散小等特点，是医学研究的有力工具，世界各国同步辐射设施正在研制许多利用同步辐射成像的系统。在这些系统中，单色x射线对物体的照射方向受到加速器产生同步辐射束的特性的限制。因此，当动脉系统和软组织重叠形成x线投影图像时，这就成为一个问题。获得靶器官的三维结构信息似乎是非常有用的，特别是在使用同步辐射单色x射线进行血管造影的情况下。本研究的目的是开发和评估通过(1)旋转物体和(2)使用劳厄晶体来减少x射线投影图像中心血管系统重叠的方法。采用弯曲磁体产生同步辐射，在PF- ar， KEK处采用多极摆动束线，在PF， KEK处采用垂直摆动束线，进行立体成像的初步实验，以确定冠状动脉的三维结构，用于静脉冠状动脉造影和微血管造影。模拟实验证实了这两种方法的可行性。该结果可应用于同步辐射单色x射线衍射增强成像（DEI）等其他成像方法。