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Monoclonal Antibody A7 Coupled to Magnetic Particles as a Contrast

Monoclonal Antibody A7 Coupled to Magnetic Particles as a Contrast
单克隆抗体 A7 与磁性粒子偶联作为对比
批准号:
13671327
负责人:
OTSUJI Eigo
金额:
$2.3万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002

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中文摘要
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英文摘要
We examined the retaining in vitro immunoreactivity of superparamagnetic iron oxide (SPIO) bound to Mab A7 and their in vivo distribution in nude mice bearing human pancreatic carcinoma xenografts were examined. A7-SPIO retained binding activities nearly identical to Mab A7. Significantly more of the radiolabeled A7-SPIO and ^<125>I labeled normal mouse IgG-SPIO disappeared from blood rapidly. As for all resected normal tissues, the accumulation levels of ^<125>I labeled A7-SPIO were lower than those for the tumors and decreased linearly with time. In MR imaging of the tumor bearing mude mice, signal intensity was reduced by the injection of A7-SPIO for the tumor
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小林真一郎: "微粒子磁性鉄標識キメラ化モノクローナル抗体A7-Fab分画を用いた直腸癌診断のためのMRI造影剤の開発に関する研究"京都府立医大雑誌. 111. 29-37 (2002)
小林真一郎:“使用微粒磁性铁标记嵌合单克隆抗体 A7-Fab 级分开发用于直肠癌诊断的 MRI 造影剂的研究”京都府立医科大学学报 111. 29-37 (2002)。
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小林真一郎: "微粒子磁性鉄標識キメラ化モノクローナル抗体A7Fab分画を用いた直腸癌診断のためのMRI造影剤の開発に関する研究"京都府立医大雑誌. 111. 29-37 (2002)
小林真一郎:“使用微粒磁性铁标记的嵌合单克隆抗体A7Fab级分开发用于直肠癌诊断的MRI造影剂的研究”京都府立医科大学学报111. 29-37 (2002)。
DOI: --
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通讯作者:
Matsumura H, Otsuji E他: "Potential usefulness of 99mTc-labeled monoclonal antibody A7 for immunoscintigraphy of human pancreatic carcinoma"Anticancer Research. 21. 3433-3438 (2001)
Matsumura H、Otsuji E 等人:“99mTc 标记的单克隆抗体 A7 对于人类胰腺癌免疫闪烁扫描的潜在用途”Anticancer Research 21. 3433-3438 (2001)。
DOI: --
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作者: []
通讯作者:
Matsumura H, Otsuji E.他: "Potential usefulness of 99mTc-labeled monoclonal antibody A7 for immunoscintigraphy of human pancreatic carcinoma"Anticancer Research. 21. 3433-3438 (2001)
Matsumura H、Otsuji E.等人:“99mTc 标记的单克隆抗体 A7 对于人类胰腺癌免疫闪烁扫描的潜在用途”Anticancer Research 21. 3433-3438 (2001)。
DOI: --
发表时间:
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影响因子: --
作者: []
通讯作者:
6
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    • 批准号:
      17591429
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      OTSUJI Eigo
    • 依托单位:
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    • 批准号:
      15591428
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2003
    • 负责人:
      OTSUJI Eigo
    • 依托单位:
    Chimeric monoclonal antibody A7-Fab coupled to magnetic particles as a contrast agent of MR imaging
    • 批准号:
      11671265
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      1999
    • 负责人:
      OTSUJI Eigo
    • 依托单位:
    Immunoguided Surgery Using Monoclonal Antibody A7 Coupled to Magnetic Particles
    • 批准号:
      09671329
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      1997
    • 负责人:
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    • 依托单位:
    海外基金