Basic study of molecular targeting agents for neutron capture therapy

中子捕获治疗分子靶向药物的基础研究

基本信息

  • 批准号:
    13671420
  • 负责人:
  • 金额:
    $ 1.54万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2003
  • 项目状态:
    已结题

项目摘要

1) cell cycle dependency of boronated compoundsTwo boronated compounds used in clinical settings (BSH & BPA) were investigated for its cell cycle dependency. Three cell lines (9L, c&, V-79) were used. The cells were incubated with boronated compounds in logarhytymic growth phase. As the results, BSH showed little cell cycle dependency when compared to BPA by examining the boron concentration after cell sorting by cell cycle using flowcytometry. The absolute cell boron concentration was higher in BPA than BSH. Based on these findings, the clinical application of two compounds may be improved (Yoshida et al. 2002)2) The uptake mechanism of BSH into the cellsBSH is composed from the carborane cage with a thiol (-SH). We have investigated the intake of BSH into three cell lines in relationship to the depletion of Glutathione (GSH), which is a major thiol compound in the cells. By depleting the GSH using BSO, the uptake of BSH was increased in all three cell lines. The neutron irradiation r … More esulted in stronger killing effect in BSO+BSH than DSH group. The gamma irradiation resulted lower killing effect in BSO+BSH than HSO group. These results indicate that uptake mechanism of BSH may be related to thiol uptake and the BSH may serve as a radioprotectant though its effect is weak3) Basic study for gadolinium neutron capture therapy (Gd-NCT)Gd-DTPA has been widely used for MRI contrast agent for CNS disease. We have investigated a new hepatocellular MRI contrast agent (Gd-BOPTA) for possible agent for Gd-NCT. The uptake of Gd-BOYTA into normal hepatic cells are thought to be mediated by molecular mechanism of ATP binding cassette (A.BC) protein. The MRI contrast in rat brain tumor model was superior in Gd-BOPTA than Gd-DTPA and the Gd concentration was higher and retained longer in Gd-BOPTA measured by ICP-AES (Zhang et al. 2002). Based on this result, we have performed a neutron irradiation experiment in rat thigh tumor model of 9L in vivo. The result revealed that Gd-BOPTA showed better tumor control than Gd-DTPA by application of the same amount of Gd into the tumor (Matsumura et al. 2003) Less
1)硼化化合物的细胞周期依赖性研究了两种用于临床的硼化化合物(BSH和BPA)的细胞周期依赖性。使用了三种细胞系(9 L、c&、V-79)。将细胞与处于对数生长期的硼化化合物一起孵育。结果,通过使用流式细胞术检查细胞分选后的硼浓度,与BPA相比,BSH显示出很小的细胞周期依赖性。BPA中的绝对细胞硼浓度高于BSH。基于这些发现,可以改进两种化合物的临床应用(Yoshida等,2002)2)BSH进入细胞的摄取机制BSH由具有硫醇(-SH)的碳硼烷笼组成。我们已经研究了BSH摄入到三个细胞系中与谷胱甘肽(GSH)消耗的关系,谷胱甘肽是细胞中主要的巯基化合物。通过使用BSO耗尽GSH,在所有三种细胞系中BSH的摄取增加。中子辐照 ...更多信息 BSO+BSH组的杀伤作用强于DSH组。γ射线照射BSO+BSH组的杀伤作用低于HSO组。这些结果表明BSH的摄取机制可能与巯基摄取有关,BSH可能具有放射防护作用,但其作用较弱。3)钆中子俘获治疗(Gd-NCT)的基础研究我们已经研究了一种新的肝细胞MRI造影剂(Gd-BOPTA)的可能代理Gd-NCT。Gd-BOYTA进入正常肝细胞被认为是通过ATP结合盒(A.BC)蛋白的分子机制介导的。在大鼠脑肿瘤模型中,Gd-BOPTA的MRI对比度上级优于Gd-DTPA,并且通过ICP-AES测量,Gd-BOPTA中的Gd浓度更高且保留时间更长(Zhang等人,2002)。在此基础上,我们进行了中子辐照大鼠大腿肿瘤模型9 L在体实验。结果显示,通过将相同量的Gd应用于肿瘤中,Gd-BOPTA显示出比Gd-DTPA更好的肿瘤控制(Matsumura等人,2003)。

项目成果

期刊论文数量(30)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tsuchiya Y: "Imaging of rabbit VX-2 hepatic cancer by cold and thermal neutron radiography"Jpn J Appl Phys. 42. 7151-7153 (2003)
土屋Y:“通过冷热中子射线照相对兔VX-2肝癌进行成像”Jpn J Appl Phys。
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    0
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  • 通讯作者:
Zhang T, Matsumura, Nose T, et al.: "Comparison of two Brain Tumor-Localizing MRI Agents : GD-BOPTA and GD-DTPA. -The study of Magnetic Resonance Imaging and Inductively Coupled Plasma Atomic Emission Spectroscopy with Rat Brain tumors"American Journal of
张 T、Matsumura、Nose T 等人:“两种脑肿瘤定位 MRI 药物的比较:GD-BOPTA 和 GD-DTPA。-磁共振成像和电感耦合等离子体原子发射光谱对大鼠脑肿瘤的研究”
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    0
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Shibata Y, Matsumura A, Nose T, et al.: "Competitive uptake of porphyrin and LDL via the LDL receptor in glioma cell lines : flow cytometric analysis"Neuro-oncology. 166. 79-87 (2001)
Shibata Y、Matsumura A、Nose T 等人:“神经胶质瘤细胞系中通过 LDL 受体竞争性摄取卟啉和 LDL:流式细胞术分析”神经肿瘤学。
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    0
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Yamamoto T, Matsumura A, Yamamoto K, Kumada H, Hori N, Torii Y, Shibata Y, Nose T: "Characterization of Neutron Beams for Boron Neutron Capture Therapy : In-air Radiobiological Dosimetry"Radiat Res. 160. 70-76 (2003)
Yamamoto T、Matsumura A、Yamamoto K、Kumada H、Hori N、Torii Y、Shibata Y、Nose T:“硼中子捕获治疗中子束的表征:空中放射生物剂量测定”辐射研究。
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    0
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高野晋吾, 坪井康次, 松村 明ら: "悪性グリオーマに対するPAV(Procarbazine, ACNU, Vincristine)療法の効果"Neuro-oncology. 11. 45-50 (2001)
Shingo Takano、Koji Tsuboi、Akira Matsumura 等人:“PAV(丙卡巴嗪、ACNU、长春新碱)治疗对恶性神经胶质瘤的影响”《神经肿瘤学》11. 45-50 (2001)。
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MATSUMURA Akira其他文献

MATSUMURA Akira的其他文献

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{{ truncateString('MATSUMURA Akira', 18)}}的其他基金

Basic research of anti-malignant tumor effect using fullerene particles and neutron capture reaction.
富勒烯粒子与中子俘获反应抗恶性肿瘤作用的基础研究。
  • 批准号:
    24659643
  • 财政年份:
    2012
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of boronated peptide using anti-oxidative effect for neutron capture therapy
利用抗氧化作用开发硼化肽用于中子捕获疗法
  • 批准号:
    21659337
  • 财政年份:
    2009
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Cell selective particle therapy for malignant brain tumor
细胞选择性粒子治疗恶性脑肿瘤
  • 批准号:
    20390379
  • 财政年份:
    2008
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Investigation of molecular mechanism in bone regeneration
骨再生的分子机制研究
  • 批准号:
    19791043
  • 财政年份:
    2007
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of Cell Selective particle irradiation using epithermal neutron beam for malignant brain tumor.
使用超热中子束进行细胞选择性粒子照射治疗恶性脑肿瘤的进展。
  • 批准号:
    17390390
  • 财政年份:
    2005
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
High Sensitive Intra-operative Fluorescent Diagnosis for Extent and Metastasis of Malignant Tumors
高灵敏术中荧光诊断恶性肿瘤的范围和转移
  • 批准号:
    12680824
  • 财政年份:
    2000
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A new type of neutron capture therapy against malignant tumors using medical nuclear reactor
利用医用核反应堆治疗恶性肿瘤的新型中子捕获疗法
  • 批准号:
    11794021
  • 财政年份:
    1999
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for University and Society Collaboration
Development of a new tumor seeking compound for neutron capture therapy
开发用于中子捕获疗法的新型肿瘤寻找化合物
  • 批准号:
    07557091
  • 财政年份:
    1995
  • 资助金额:
    $ 1.54万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

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