A study on the mechanism of General Anesthesia-inuduced sleep-relation to endogenous sleep related substances

全身麻醉诱发睡眠与内源性睡眠相关物质的机制研究

• 批准号: 13671560
• 负责人: MATSUKI Akitomo
• 金额: $ 1.41万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671560/
• 关键词: General anesthetic agents; Sleep; Noradrenaline; Sleep Related Substance

We studied an interaction among general anesthetics and endogenous sleep-related substance. It is suggested that post anesthesia sleep was affected by ketamine, a general anesthetics. We found that non-rapid eye movement sleep (NREMS) was reduced but REMS was increased after a few days later of ketamine anesthesia On the other hand, orexin, a wake-promote substance thus sleep-related substance, decreased anesthesia-induced loss of consciousness duration by several intravenous general anesthetics ; pentobarbital, thiopental and phenobarbital. Our results suggest that there would be some interaction among general anesthetics and endogenous sleep-related substance.

我们研究了全身麻醉药和内源性睡眠相关物质之间的相互作用。有人认为麻醉后睡眠受到氯胺酮（一种全身麻醉剂）的影响。我们发现，氯胺酮麻醉几天后，非快速眼动睡眠（NREMS）减少，但 REMS 增加。另一方面，食欲素（一种促醒物质，因此与睡眠相关的物质）可以减少几种静脉全身麻醉药引起的麻醉引起的意识丧失持续时间；戊巴比妥、硫喷妥和苯巴比妥。我们的结果表明全身麻醉药和内源性睡眠相关物质之间存在一定的相互作用。

项目成果

Tetsuya Kushikata, Kazuyoshi Hirota, Hitoshi Yishida, Naoki Kotani, Akitomo Matsuki: "Orexin Decreases Barbiturates-Induced Sleeping Time"Anesthesiology. 95. A1371 (2001)

Tetsuya Kushikata、Kazuyoshi Hirota、Hitoshi Yishida、Naoki Kotani、Akitomo Matsuki：“食欲素减少巴比妥类药物诱导的睡眠时间”麻醉学。

Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, Tsuyoshi Kudo, David G.Lambrt, Akitomo Matsuki: "Orexin A and b evoke noradrenaline release from rat cerebrocortical slices"British Journal of Pharmacology. 134. 1461-1466 (2001)

Kazuyoshi Hirota、Tetsuya Kushikata、Mihoko Kudo、Tsuyoshi Kudo、David G.Lambrt、Akitomo Matsuki：“Orexin A 和 b 引起大鼠脑皮质切片去甲肾上腺素释放”英国药理学杂志。

Tetsuya Kushikata, Kazuyoshi Hirota, Hitoshi Yishida, et al.: "Orexin Decreases Barbiturates-Induced Sleeping Time"Anesthesiology. 95. A1371 (2001)

Tetsuya Kushikata、Kazuyoshi Hirota、Hitoshi Yishida 等人：“Orexin 减少巴比妥类药物诱导的睡眠时间”麻醉学。

Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, et al.: "Orexin A and b evoke noradrenaline release from rat cerebrocortical slices"British Journal of Pharmacology. 134. 1461-1466 (2001)

Kazuyoshi Hirota、Tetsuya Kushikata、Mihoko Kudo 等人：“Orexin A 和 b 引起大鼠脑皮质切片去甲肾上腺素释放”《英国药理学杂志》。