A study on the mechanism of General Anesthesia-inuduced sleep-relation to endogenous sleep related substances

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We studied an interaction among general anesthetics and endogenous sleep-related substance. It is suggested that post anesthesia sleep was affected by ketamine, a general anesthetics. We found that non-rapid eye movement sleep (NREMS) was reduced but REMS was increased after a few days later of ketamine anesthesia On the other hand, orexin, a wake-promote substance thus sleep-related substance, decreased anesthesia-induced loss of consciousness duration by several intravenous general anesthetics ; pentobarbital, thiopental and phenobarbital. Our results suggest that there would be some interaction among general anesthetics and endogenous sleep-related substance.