Clinical study for target control infusion system with processed EEG

研究了催眠终点和/或处理后的脑电变量，如脑电双频指数(BIS)、95%频谱边缘频率(95%SEF)和中值频率(MF)，以监测全静脉注射(IV)期间的觉醒(催眠)深度。麻醉。在这项研究中，催眠终点的语言指令无反应(UVC)，睫毛反射消失(LER)和身体运动反应机械鼻膜刺激(简称NBMR)与BIS，95%SEF和MF在异丙酚()SY+-。[]芬太尼静脉注射麻醉。42例患者随机分为丙泊酚30 mg kg&lt；d1-1@gt；d1h&lt；d1-1@gt；d1-1@d1；d1静脉滴注异丙酚30 mg kg&lt；d1-1@&gt；d1+芬太尼推注2mug kg&lt(P，n=22)。(PE，n=20)。在UVC、LER和NBMR抑制(INBMR)时监测和记录BIS、95%SEF、MF和异丙酚剂量。PF组的BIS值显著高于P组，即74.7(]sy.+-)。[)10.9，73.1(]sy.+-.[)10.5和47.1(]SY+-。[)9.2对65.8(SY+-)。[)9.8，59.6(]SY.+-.[)10和33.8()sy.+-。[)5.7分别在UVC、LER和INBMR。PF组达到催眠终点所需的异丙酚剂量明显低于P组。异丙酚在INBMR时的血浆浓度，PF组低于P组(9.2()sy.+-。[)2.0mug ml&lt；@d1-1@&gt；d1 ys.14.1(]sy.+-.[)4.2mug ml；d1-1@&gt；d1)。我们的结果表明，芬太尼预处理增强了异丙酚的作用，并在较高的BIS值和较低的异丙酚剂量和浓度(在INBMR测量)下达到催眠终点，并且BIS依赖于麻醉方案来监测麻醉深度。

Hypnotic endpoints and/or processed EEG variables, e.g., bispectral index (BIS), 95% spectral edge frequency (95%SEF)and median frequency (MF) have been studied to monitor anaessthetic (hypnosis) depth during total intravenous (i.v.) anaesthesia. In this study, the relationship between the hypnotic endpoints of unresponsiveness to verbal commands (UVC), loss of eyelash reflex (LER) and body movement response to mechanical nasal membrane stimulation (abbreviated as NBMR) vs. BIS,95% SEF and MF during propofol(]SY.+-。[)fentanyl i.v.anaesthesia is presented. Forty-two patients were randomly assigned to receive either propofol infusion, 30 mg kg<@D1-1@>D1h<@D1-1@>D1 (P,n=22) or propofol infusion, 30 mg kg<@D1-1@>D1h<@D1-1@>D1+fentanyl bolus, 2mug kg<@D1-1@>D1 iv. (PE,n=20). BIS,95% SEF and MF and propofol doses were monitored and recorded at UVC,LER and inhibition of NBMR (INBMR). The BIS values were significantly higher in the PF as compared to the P group, i.e., 74.7(]SY.+-。[)10.9,73.1(]SY.+-。[)10.5 and 47.1(]SY.+-。[)9.2 vs.65.8(]SY.+-。[)9.8,59.6(]SY.+-。[)10 and 33.8(]SY.+-。[)5.7 at UVC,LER and INBMR,respectively. Doses of propofol for achieving the hypnotic endpoints were significantly lower in the PF group as comparedto the P group. Plasma propofol concentrations at INBMR were lower in the PF as compared to the P group (9.2(]SY.+-。[)2.0 mug ml<@D1-1@>D1 ys.14.1(]SY.+-。[)4.2mug ml<@D1-1@>D1). Our results suggest that fentanyl pretreatment potentiates the effects of propofol and achieves the hypnotic endpoints at higher BIS values and lower propofoldoses and concentrations (measured at INBMR) and that the BIS is dependent on the anaesthetic regimen for monitoring the depth of anaesthesia.