Clinical study for target control infusion system with processed EEG

催眠终点和/或处理的EEG变量，例如，研究了脑电双频指数（BIS）、95%边缘频率（95%SEF）和中值频率（MF）在全静脉（i. v.）麻醉。本研究比较了异丙酚催眠时对口头命令无反应（UVC）、睫毛反射消失（LER）和机械鼻膜刺激的体动反应（NBMR）与BIS、95%SEF和MF的关系。[）芬太尼静脉麻醉。42例患者随机分为两组：异丙酚组（30 mg kg<@D1 - 1@> D1 h <@D1-1@>D1）和异丙酚组（30 mg kg<@D1 - 1 @> D1 h <@D1 - 1 @>D1+芬太尼2 μ g kg<@D1-1@>D1）。(PE，n=20）。在UVC、LER和NBMR抑制（INBMR）时监测并记录BIS、95%SEF、MF和丙泊酚剂量。PF组的BIS值显著高于P组，即，74.7（]SY. ±. [）10.9，73.1（）SY. ±. [）10.5和47.1（]SY. ±. [)9.2 vs.65.8（]SY. ±. [)9.8，59.6（±）SY. [)10和33.8（]SY ±. [)5.7在UVC，LER和INBMR。与P组相比，PF组达到催眠终点所需的丙泊酚剂量显著降低。与P组相比，PF组在INBMR时的血浆丙泊酚浓度较低（9.2（± SD））。[)2.0 1 μ g ml<@D1-1@>D1 ys.14.1（]SY. ±. [）4.2 μ g ml<@D1-1@>D1）。我们的研究结果表明，芬太尼预处理增强丙泊酚的作用，并在较高的BIS值和较低的丙泊酚剂量和浓度（在INBMR测量）下达到催眠终点，BIS依赖于监测麻醉深度的麻醉方案。

Hypnotic endpoints and/or processed EEG variables, e.g., bispectral index (BIS), 95% spectral edge frequency (95%SEF)and median frequency (MF) have been studied to monitor anaessthetic (hypnosis) depth during total intravenous (i.v.) anaesthesia. In this study, the relationship between the hypnotic endpoints of unresponsiveness to verbal commands (UVC), loss of eyelash reflex (LER) and body movement response to mechanical nasal membrane stimulation (abbreviated as NBMR) vs. BIS,95% SEF and MF during propofol(]SY.+-。[)fentanyl i.v.anaesthesia is presented. Forty-two patients were randomly assigned to receive either propofol infusion, 30 mg kg<@D1-1@>D1h<@D1-1@>D1 (P,n=22) or propofol infusion, 30 mg kg<@D1-1@>D1h<@D1-1@>D1+fentanyl bolus, 2mug kg<@D1-1@>D1 iv. (PE,n=20). BIS,95% SEF and MF and propofol doses were monitored and recorded at UVC,LER and inhibition of NBMR (INBMR). The BIS values were significantly higher in the PF as compared to the P group, i.e., 74.7(]SY.+-。[)10.9,73.1(]SY.+-。[)10.5 and 47.1(]SY.+-。[)9.2 vs.65.8(]SY.+-。[)9.8,59.6(]SY.+-。[)10 and 33.8(]SY.+-。[)5.7 at UVC,LER and INBMR,respectively. Doses of propofol for achieving the hypnotic endpoints were significantly lower in the PF group as comparedto the P group. Plasma propofol concentrations at INBMR were lower in the PF as compared to the P group (9.2(]SY.+-。[)2.0 mug ml<@D1-1@>D1 ys.14.1(]SY.+-。[)4.2mug ml<@D1-1@>D1). Our results suggest that fentanyl pretreatment potentiates the effects of propofol and achieves the hypnotic endpoints at higher BIS values and lower propofoldoses and concentrations (measured at INBMR) and that the BIS is dependent on the anaesthetic regimen for monitoring the depth of anaesthesia.