Clinical study for target control infusion system with processed EEG

脑电图处理靶控输注系统临床研究

• 批准号: 08457398
• 负责人: MATSUKI Akitomo
• 金额: $ 2.24万
• 依托单位: HIROSAKI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457398/
• 关键词: Anaesthesia; propofol; monitoring; bispectral index; median frequency; 95% spectral edge frequency; nasal reflex; eyelash reflex; フェンタニール血中濃度; ケタミン血中濃度; Bispectral index

Hypnotic endpoints and/or processed EEG variables, e.g., bispectral index (BIS), 95% spectral edge frequency (95%SEF)and median frequency (MF) have been studied to monitor anaessthetic (hypnosis) depth during total intravenous (i.v.) anaesthesia. In this study, the relationship between the hypnotic endpoints of unresponsiveness to verbal commands (UVC), loss of eyelash reflex (LER) and body movement response to mechanical nasal membrane stimulation (abbreviated as NBMR) vs. BIS,95% SEF and MF during propofol(]SY.+-。[)fentanyl i.v.anaesthesia is presented. Forty-two patients were randomly assigned to receive either propofol infusion, 30 mg kg<@D1-1@>D1h<@D1-1@>D1 (P,n=22) or propofol infusion, 30 mg kg<@D1-1@>D1h<@D1-1@>D1+fentanyl bolus, 2mug kg<@D1-1@>D1 iv. (PE,n=20). BIS,95% SEF and MF and propofol doses were monitored and recorded at UVC,LER and inhibition of NBMR (INBMR). The BIS values were significantly higher in the PF as compared to the P group, i.e., 74.7(]SY.+-。[)10.9,73.1(]SY.+-。[)10.5 and 47.1(]SY.+-。[)9.2 vs.65.8(]SY.+-。[)9.8,59.6(]SY.+-。[)10 and 33.8(]SY.+-。[)5.7 at UVC,LER and INBMR,respectively. Doses of propofol for achieving the hypnotic endpoints were significantly lower in the PF group as comparedto the P group. Plasma propofol concentrations at INBMR were lower in the PF as compared to the P group (9.2(]SY.+-。[)2.0 mug ml<@D1-1@>D1 ys.14.1(]SY.+-。[)4.2mug ml<@D1-1@>D1). Our results suggest that fentanyl pretreatment potentiates the effects of propofol and achieves the hypnotic endpoints at higher BIS values and lower propofoldoses and concentrations (measured at INBMR) and that the BIS is dependent on the anaesthetic regimen for monitoring the depth of anaesthesia.

研究了催眠终点和/或处理的EEG变量，如双谱指数（BIS）、95%谱边缘频率（95% sef）和中位数频率（MF），以监测全静脉（i.v）麻醉期间的麻醉（催眠）深度。在本研究中，研究了异丙酚（SY.+-）作用下无语言命令反应（UVC）、睫毛反射丧失（LER）和身体运动对机械鼻膜刺激（简称NBMR）的催眠终点与BIS、95% SEF和MF之间的关系。[]芬太尼静脉麻醉。42例患者随机分配接受丙泊酚输注30 mg kg<@D1-1@>D1h<@D1-1@>D1 （P,n=22）或丙泊酚输注30 mg kg<@D1-1@>D1h<@D1-1@>D1+芬太尼丸，2mug kg<@D1-1@>D1 iv （PE,n=20）。监测BIS、95% SEF、MF和异丙酚剂量，并记录UVC、LER和NBMR抑制作用（INBMR）。与P组相比，PF组的BIS值显著高于P组，即74.7(]SY.+- - [)10.9,73.1(]SY.+- -[)10.5和47.1(]SY.+- - [)9.2 vs.65.8(]SY.+-。[9.8, 59.6] SY。+ -。在UVC、LER和INBMR上分别为[)10和33.8(]SY.+- .[)5.7。与P组相比，PF组实现催眠终点的异丙酚剂量显著降低。与P组相比，PF组INBMR时血浆丙泊酚浓度较低(9.2（]SY.+- . [)2.0 mug ml<@D1-1@>D1; 14.1(]SY.+- . [)4.2mug ml<@D1-1@>D1）。我们的研究结果表明，芬太尼预处理增强了异丙酚的作用，并在较高的BIS值和较低的异丙酚剂量和浓度（以INBMR测量）下达到催眠终点，并且BIS依赖于监测麻醉深度的麻醉方案。

项目成果

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