Quantitative analysis of higher-order wavefront aberration and irregular astigmatism and assessment of their influence on visual function

我们研究了定量分析高阶像差和不规则散光的方法，这些像差和不规则散光来自角膜前表面以及整个眼睛结构。利用傅立叶级数谐波分析对角膜的视频角膜图像数据进行分解，并将不规则散光（不对称分量和高阶不规则性）与规则形式的散光分离。该方法适用于各种眼科疾病和眼科手术。我们利用傅立叶分析连续分析影像角膜摄影资料，以定量评估圆锥角膜的纵向发展。屈光性角膜切削术后，不规则散光的增加与对比敏感度的下降显著相关。通过将波前数据扩展为Zernike系数来量化眼睛的高阶像差。用三阶系数的均方根值来描述彗差 ...更多信息 发现白内障眼的总高阶像差明显增加，核性白内障眼与皮质性白内障眼的像差模式有显著差异。在人工晶状体眼，测量表观调节量，并评估角膜多焦性和角膜像差。结果表明，视调节的大小与角膜多焦度的大小有明显的相关性。我们还发现角膜彗差与表观调节显著相关，而角膜球面像差与表观调节无关。PSF和MTF的计算机模拟表明，0.5屈光度的焦点偏移恶化的视网膜图像显着更高阶像差的眼睛比在眼睛中有中等量的昏迷样像差。使用视频角膜摄影数据的傅立叶分析，定义角膜不规则散光指数（不对称性和高阶不规则性）的正常范围。使用正常范围对眼部病理和术后情况进行评估。

We investigated the methods to quantitatively analyze higher-order aberrations and irregular astigmatism which arise from the anterior surface of the cornea as well as whole eye structure. The videokeratography data of the cornea were decomposed using Fourier series harmonic analysis, and irregular astigmatism (asymmetry component and higher-order irregularity) were separated from the regular form of astigmatism. This method was applied for various ocular diseases and ophthalmic surgical procedures. We quantitatively evaluated the longitudinal progression of keratoconus by serially analyze videokeratography data with Fourier analysis. In eyes after photorefractive keratectomy, increases in irregular astigmatism component were significantly correlated with deterioration of contrast sensitivity. Higher-order aberration of the eye was quantified by expanding the wavefront data into Zernike coefficients. Root-mean-square of third order coefficients was used to describe coma-like aberration … More , and root-mean-square of fourth order coefficients was used to denote spherical-like aberration, We found that total higher-order aberrations were significantly increased in eyes with cataract, and that the pattern of aberrations was markedly different between eyes with nuclear cataract and cortical cataract. In pseudophakic eyes, amount of apparent accommodation was measured, and corneal multifocality and corneal aberration were assessed. It was indicated that the mount of apparent accommodation was significantly correlated with the amount of corneal multifocality. We also found that corneal coma aberration was significantly correlated with apparent accommodation, but corneal spherical aberration was not. Computer simulation of PSF and MTF demonstrated that a focus shift of 0.5 diopter deteriorated the retinal image significantly more in eyes without higher-order aberrations than in eyes with a moderate amount of coma-like aberrations. Using Fourier analysis of videokeratography data, the normal range was defined for the cornea irregular astigmatism index (asymmetry and higher order irregularity). Eyes with ocular pathologic and postsurgical conditions were evaluated using the normal range Less