Investigation on three-dimensional optical biopsy using next generation polarization sensitive optical coherence tomography

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We developed a new polarization sensitive three-dimensional anterior segment optical coherence tomography which can be used in practice, with which basic data were obtained in animal eyes and clinical data were collected in human eyes at the outpatient clinic. In animal eyes, the relationship between scleral birefringence and tissue elasticity was investigated. In human eyes, birefringence was measured in eyes with various ocular conditions and after surgery. Especially in eyes with keratoconus, a new protocol for early detection of keratoconus was developed employing parameters such as asymmetry, distribution and intensity of birefringence in addition to conventional parameters related to corneal topographic abnormality.