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Influence of wavefront aberration and scattering in the ocular optical system on visual function

眼光学系统波前像差和散射对视功能的影响

基本信息

批准号：
16390493
负责人：
OSHIKA Tetsuro
金额：
$ 8.64万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

We investigated changes in optical quality of the eye and quality of vision in various ocular conditions. First, in order to assess the age-related changes in wavefront aberration, corneal and ocular wavefront aberrations were measured in normal human eyes. It was found that corneal coma aberration increases along with aging, and age-related increases in lenticular spherical aberration contribute to the increases in spherical aberration of the eye. Changes in wavefront aberration of the eye and changes in contrast sensitivity after laser in situ keratomileusis (LASIK) were assessed. It was revealed that LASIK significantly increases ocular wavefront aberration, which induces significant deterioration of contrast sensitivity after surgery. In eyes with cataract, we reported the possibility that visual function can be quantitatively and comprehensively evaluated by measuring scattering of the lens and wavefront analysis of the eye. We also reported several articles about the methods to q … More uantitatively analyze corneal irregular astigmatism, one of which is to decompensate corneal topography data using Fourier series harmonic analysis into spherical, cylindrical, asymmetrical, and higher irregular components. In excimer laser refractive surgery, we compared PRK and LASIK in terms of their influence on corneal functional stability and visual function. In another study, we reported that, in eyes with larger photopic pupil diameter, increases in spherical-like aberration dominantly affect contrast sensitivity, whereas in eyes with smaller pupil size, changes in coma-like aberration exert greater influence on visual performance. In cataract surgery, we found that both the SA60AT single-piece and MA60AC 3-piece lenses showed a minimum amount of decentration, tilt, anterior capsule contraction, and PCO. Although the MA60AC showed significant forward shift and myopic refractive changes after surgery, the SA60AT displayed little axial movement associated with highly stable refraction after surgery. This feature of the SA60AT should facilitate earlier spectacle prescription and quicker visual/social rehabilitation of patients after cataract surgery. In a study to investigate the relation between contrast sensitivity function and ocular higher-order wavefront aberrations in normal human eyes, it was found that aberration of the eye significantly influences contrast sensitivity function. We evaluated relationships among contrast sensitivity function, ocular higher-order aberration, and myopic correction in eyes undergoing overnight orthokeratology for myopia, and found that orthokeratology significantly increases ocular higher-order aberrations and compromises contrast sensitivity function, depending on the amount of myopic correction. Less

我们调查了在不同的眼睛条件下眼睛的光学质量和视觉质量的变化。首先，为了评估与年龄相关的波前像差的变化，测量了正常人眼的角膜和眼波前像差。研究发现，随着年龄的增长，角膜混浊像差增加，晶状体球差随年龄的增加而增加。观察准分子激光原位角膜磨镶术(LASIK)术后眼波前像差和对比敏感度的变化。结果表明，准分子激光原位角膜磨镶术明显增加了眼部波前像差，导致术后对比敏感度明显下降。在白内障患者中，我们报道了通过测量晶状体的散射度和眼的波前分析来定量和综合评价视功能的可能性。我们还报道了几篇关于Q…方法的文章更定量地分析了角膜不规则散光，其中之一是利用傅里叶级数调和分析将角膜地形图数据分解为球面、柱面、不对称和更高的不规则分量。在准分子激光屈光手术中，我们比较了PRK和LASIK对角膜功能稳定性和视功能的影响。在另一项研究中，我们报道了，在明视瞳孔直径较大的眼睛中，球面像差的增加主要影响对比敏感度，而在瞳孔较小的眼睛中，昏迷像差的变化对视觉表现的影响更大。在白内障手术中，我们发现SA60AT单片式和MA60AC三片式晶状体都表现出最小的偏心、倾斜、前囊收缩和后囊膜混浊。虽然MA60AC术后有明显的前移和近视屈光变化，但SA60AT术后几乎没有轴向运动和高度稳定的屈光度。SA60AT的这一功能应该有助于白内障手术后患者更早地配戴眼镜，并更快地进行视觉/社会康复。在研究正常人眼高阶波前像差与对比敏感度函数关系的研究中，发现人眼的像差对对比敏感度函数有显著影响。我们评估了接受过夜角膜矫形术治疗近视的眼睛的对比敏感度功能、眼高阶像差和近视矫正之间的关系，发现矫正角膜塑形术显著增加了眼部高阶像差，并损害了对比敏感度功能，这取决于近视矫正量。较少