STUDY ON PROKIFERATIVE DIABETIC RETINOPATHY OF DIABTIC RAT(WBN/Kob)

糖尿病大鼠促发性糖​​尿病视网膜病变(WBN/Kob)的研究

• 批准号: 13671860
• 负责人: MATSUURA Tetsuro
• 金额: $ 0.96万
• 依托单位: SETSUNAN UNIVERCITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671860/
• 关键词: Retinopathy; Diabetic retinopathy; Neovascularization; WBN; Kob; Rat

We investigate the histopathological changes of the fundus in aged male rats of WBN/Kob strain to ascertain whether proliferative diabetic retinopathy is induced or not. Severe hyperglycemia and glucosuria lasted from 10 months to 24 months of age in male rats. In male rats, the vitreous body was partially or entirely filled with fibrous tissue corresponding to the grossly white mass on both sides. The newly formed vessels remarkably increased within the fibrous tissue in the vitreous body. In non-diabetic females, these changes were not seen. WBN/Kob rats are likely to be one of the diabetic animal models for progressive diabetic retinopathy and may provide further informations to cause of retinal angiogenesis.

本研究通过观察WBN/Kob系老年雄性大鼠眼底组织病理学改变，探讨增殖性糖尿病视网膜病变是否已被诱导。雄性大鼠严重的高血糖和糖尿从10月龄持续到24月龄。在雄性大鼠中，玻璃体部分或全部充满纤维组织，对应于两侧的大体白色肿块。玻璃体内纤维组织内新生血管明显增多。在非糖尿病雌性动物中，未观察到这些变化。WBN/Kob大鼠有可能成为进行性糖尿病视网膜病变的动物模型之一，并为进一步研究视网膜血管生成提供依据。

项目成果

T Matsuura, K.Ozaki, Y Kodama, Y.Kondo, I.Narama: "Proliferative changes in the fundus of diabetic rats (WBN/Kob)"Folia Opthalmologica Japonica. 54・3. (2003)

T Matsuura、K.Ozaki、Y Kodama、Y.Kondo、I.Narama：“糖尿病大鼠眼底的增殖性变化（WBN/Kob）”Folia Opthalmologica Japonica（2003）。

松浦哲郎, 前野亜紀子, 尾崎清和, 奈良間功: "WBN/Kobラットの網膜および硝子体に認められた増殖性変化"Diabetes Frontier. 12. 806-807 (2001)

Tetsuro Matsuura、Akiko Maeno、Kiyokazu Ozaki、Isao Narama：“WBN/Kob 大鼠视网膜和玻璃体中观察到的增殖变化”糖尿病前沿。12. 806-807 (2001)

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Narama, I., Imaida, K., Iwata, H., Nakae, D., Nishikawa, A., Harada, T.: "A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology"Toxicol Pathol. 1

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