Characterizing the prevalence and nature of facial recognition deficits in non-proliferative diabetic retinopathy

描述非增殖性糖尿病视网膜病变中面部识别缺陷的患病率和性质

• 批准号: 10667781
• 负责人: MICHAEL J WENGER
• 金额: $ 19.21万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667781
• 关键词: Address; Affect; Age; Age related macular degeneration; American; Architecture; Attention; Background Diabetic Retinopathy; Behavior Therapy; Blindness; Complex; Contrast Sensitivity; Detection; Diabetes Mellitus; Diabetic Retinopathy; Diffuse; Early identification; Experimental Designs; Face; Face Processing; Glaucoma; Goals; Hemorrhage; Impairment; Individual; Intervention; Literature; Measures; Mediating; Medical; Memory; Microaneurysm; Modeling; Monitor; Nature; Neuropsychology; Oklahoma; Pathology; Patient Self-Report; Patients; Pattern; Perception; Performance; Prevalence; Quality of life; Questionnaires; Race; Reading; Reporting; Research; Retinal Diseases; Retinal Neovascularization; Sampling; Severities; Structural defect; Symptoms; Systems Theory; Translating; Variant; Venous; Vision; Visual; Visual Acuity; Well in self; Work; age group; cognitive function; experience; face perception; macula; macular edema; novel; proliferative diabetic retinopathy; reading difficulties; recruit; sex; skills; social; systematic review; theories; vascular abnormality; visual memory

Project summary/abstract Facial perception and memory are visual abilities that are driven by an interplay between low-level visual and higher-level cognitive functioning. Deficits in facial perception and memory are associated with diminished quality of life and a range of social challenges, and it has been suggested that this functional deficit may be an early marker for the later onset of structural abnormalities in a variety of conditions. One of these conditions—one that has received scant attention—is diabetic retinopathy. In a recent systematic review, difficulty in perceiving faces was noted as one of the greatest subjective restrictions on visual functioning. Diabetic retinopathy affects approx- imately one-third of individuals with diabetes world-wide. The vision loss associated with diabetic retinopathy is preventable, given early identification, medical intervention and monitoring, and behavioral interventions. Diabetic retinopathy can be generally separated into two classes. The first is non-proliferative diabetic retinopathy, which is characterized by micro-aneurysms, intraretinal hemorrhages, venous beading or intra-retinal microvascular ab- normalities. The second is proliferative diabetic retinopathy, which is characterized by retinal neovascularization. In cases of macular edema, there is a thickening of the macula which can result in the loss of central vision. Deficits in face processing have been studied more frequently in two pathologies that affect the macula: age- related macular degeneration (AMD) and glaucomatous macular damage. Patients with AMD regularly identify facial processing as tasks with which they experience significant difficulty. In the literature on AMD, deficits in facial processing have been identified as significant components of quality of life. The magnitude of the deficits in facial processing in AMD are such that they are second only to deficits in reading in subjective complaints. Finally, it has been noted that deficits in facial processsing are among the first subjectively-reported symptoms of AMD, often occurring before the detection of structural abnormalities. With respect to deficits in facial percep- tion and memory in glaucomatous macular damage, there is evidence that significant impairments exist despite patients having good central visual acuity. In addition, the amount of the diffuse macular damage is significantly related to impairments in contrast sensitivity and measures of facial recognition and identification. It has been suggested that other related visual pathologies—including diabetic retinopathy—should show similar patterns of performance deficits. However, very little work on this issue has been done in the case of diabetic retinopa- thy. The work proposed here represents an important first step in addressing this need. The accomplishment of this work will result in the first quantification of the prevalence and severity of deficits in facial processing in diabetic retinopathy, the first analytic empirical treatment of the pathology-related differences in processing feat- ural and configural information, and the first theoretical treatment of those differences. The novel application of two meta-theories using a new experimental design, along with a modeling approach capable of relating those meta-theories has the potential to be transformative in this domain.

项目概要/摘要 面部感知和记忆是由低级视觉和记忆之间相互作用驱动的视觉能力。 更高层次的认知功能。面部感知和记忆的缺陷与质量下降有关 生活和一系列社会挑战，并且有人认为这种功能缺陷可能是早期的 多种情况下随后发生的结构异常的标志。这些条件之一—— 糖尿病视网膜病变却很少受到关注。在最近的一项系统综述中，感知面孔的困难 被认为是对视觉功能最大的主观限制之一。糖尿病视网膜病变影响大约 全世界有三分之一的人患有糖尿病。与糖尿病视网膜病变相关的视力丧失是 通过早期识别、医疗干预和监测以及行为干预，是可以预防的。糖尿病患者 视网膜病变通常可分为两类。第一种是非增殖性糖尿病视网膜病变， 其特征是微动脉瘤、视网膜内出血、静脉串珠或视网膜内微血管异常 常态。第二种是增殖性糖尿病视网膜病变，其特征是视网膜新生血管形成。 在黄斑水肿的情况下，黄斑增厚，可能导致中央视力丧失。 面部处理缺陷在影响黄斑的两种病理中得到了更频繁的研究：年龄- 相关黄斑变性（AMD）和青光眼黄斑损伤。 AMD 患者定期识别 面部处理是他们遇到很大困难的任务。在有关 AMD 的文献中， 面部处理已被确定为生活质量的重要组成部分。赤字的严重程度 AMD 的面部处理缺陷在主观抱怨中仅次于阅读缺陷。 最后，人们注意到，面部处理缺陷是最先主观报告的症状之一。 AMD 的发生，通常发生在检测到结构异常之前。关于面部知觉缺陷 青光眼性黄斑损伤的影响和记忆力方面，有证据表明，尽管 中心视力良好的患者。此外，弥漫性黄斑损伤的程度也显着增加。 与对比敏感度以及面部识别和识别测量的损伤有关。它一直 表明其他相关的视觉病变——包括糖尿病视网膜病变——应该表现出类似的模式 绩效缺陷。然而，对于糖尿病视网膜病变，在这个问题上所做的工作却很少。 你的。这里提出的工作代表了解决这一需求的重要的第一步。成就 这项工作将首次量化面部处理缺陷的普遍性和严重性 糖尿病视网膜病变，第一个针对处理特征中病理相关差异的分析经验治疗 视觉和配置信息，以及对这些差异的首次理论处理。新颖的应用 使用新的实验设计的两种元理论，以及能够将这些理论联系起来的建模方法 元理论有潜力在这个领域带来变革。