Brain-gut-retina axis in diabetic retinopathy

糖尿病视网膜病变中的脑-肠-视网膜轴

基本信息

  • 批准号:
    10595142
  • 负责人:
  • 金额:
    $ 55.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

Summary Abstract This application puts for the notion of a brain-gut- retinal axis that becomes dysfunctional in diabetic retinopathy (DR). The innate immune system has been strongly implicated in the pathogenesis of DR, but less is known about the role of the adaptive immune system. At the interface of these two systems is a critical population of cells, Th17 cells, that typically reside in the gut during health. Th17 cells have homeostatic properties, mediating host defense against bacterial and fungal infections; however, it remains unclear how intestinal Th17 cells integrate diverse signals into a set of cellular programs that allow them to maintain tissue homeostasis yet also become pathogenic, serving as primary drivers of tissue inflammation. We have identified a critical role of somatostatinergic neurons in the paraventricular nucleus of the hypothalamus (PVN) in regulation of immune function through “loss of function” studies and “gain of function studies. SST expression is dramatically reduced in the PVN of diabetic animals. Hypothalamic dysfunction, as seen in diabetes, has the capacity to induce injury directly through hyperactivation of sympathetic nerves. Based on preliminary and published data, we put for the hypothesis that: Diabetes-induced loss of inhibitory SST neurons in the PVN drives increased autonomic input to the intestine shifting Th17 cells from a homeostatic to a pathologic state. Pathologic Th17 cells leave the intestine and traffic to areas of tissue injury such as the retina in DR. In the retina the pathologic Th17 cells secrete proinflammatory cytokines that recruitment innate immune cells into the retina exacerbating DR. To examine this hypothesis, we propose the following aims: Aim 1: To test if impaired function of hypothalamic SST neurons in diabetes contributes to hyperactivity of autonomic efferents to the gut and increases activation of enteric neurons. Aim 2: To selectively ablate SST PVN neurons (in the absence of diabetes) and evaluate if this results in increased autonomic input to the gut and a shift from “homeostatic” Th17 cells to a “pathogenic” Th17 cells that migrate to the retina and recruit circulating immune cells. Aim 3: To determine if maintaining hypothalamic SST levels at nondiabetic levels in diabetic mice will preserve the function of homeostatic Th17 cells in the gut and prevent their recruitment to the retina delaying the development of DR. Impact: SST analogues may provide an important complementary strategy for DR management by preventing increased sympathetic drive to the gut and Th17 cell dysfunction.
摘要 这一应用提出了糖尿病患者脑-肠-视网膜轴功能障碍的概念。 视网膜病变(DR)。先天免疫系统与DR的发病机制密切相关, 但对适应性免疫系统的作用知之甚少。在这两个系统的界面上, 一个关键的细胞群体,Th 17细胞,通常在健康期间驻留在肠道中。Th 17细胞 稳态特性,介导宿主防御细菌和真菌感染;然而, 目前尚不清楚肠道Th 17细胞如何将不同的信号整合到一组细胞程序中, 使它们能够维持组织的稳态,但也成为致病性的,作为主要的驱动因素, 组织炎症我们已经确定了生长抑素能神经元在室旁核中的关键作用, 下丘脑核(PVN)通过“功能丧失”研究调节免疫功能 和“功能增益研究”。SST表达在糖尿病动物的PVN中显著降低。 下丘脑功能障碍,如糖尿病所见,有能力直接通过 交感神经过度激活根据初步和公布的数据,我们提出 假设:糖尿病引起的室旁核抑制性SST神经元的丢失驱动自主神经功能的增加, 输入到肠道,使Th 17细胞从稳态转变为病理状态。Th 17细胞 离开肠道和交通组织损伤的地区,如视网膜在DR。在视网膜, 病理性Th 17细胞分泌促炎细胞因子,其将先天性免疫细胞募集到免疫系统中。 为了检验这一假设,我们提出了以下目标:目标1:测试是否 糖尿病下丘脑SST神经元功能受损导致自主神经功能亢进 向肠道传出并增加肠神经元的激活。目的2:选择性消融SST PVN 神经元(在没有糖尿病的情况下),并评估这是否会导致肠道自主神经输入增加 以及从“稳态”Th 17细胞向“致病性”Th 17细胞的转变, 募集循环免疫细胞。目的3:确定是否维持下丘脑SST水平在 糖尿病小鼠中的非糖尿病水平将保持肠道中稳态Th 17细胞的功能, 阻止其招募到视网膜,延迟DR的发展。影响:SST类似物可能 通过防止交感神经系统的增加,为DR管理提供重要的补充策略 驱动肠道和Th 17细胞功能障碍。

项目成果

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CHARLES J FRAZIER其他文献

CHARLES J FRAZIER的其他文献

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{{ truncateString('CHARLES J FRAZIER', 18)}}的其他基金

Novel Aspects of Central Oxytocin Signaling Relevant to Mood/Anxiety Disorders
与情绪/焦虑障碍相关的中枢催产素信号的新方面
  • 批准号:
    9014566
  • 财政年份:
    2015
  • 资助金额:
    $ 55.06万
  • 项目类别:
Novel Aspects of Central Oxytocin Signaling Relevant to Mood/Anxiety Disorders
与情绪/焦虑障碍相关的中枢催产素信号的新方面
  • 批准号:
    8888289
  • 财政年份:
    2015
  • 资助金额:
    $ 55.06万
  • 项目类别:
CB1R independent effects of cannabinoids on synaptic physiology in the CNS.
大麻素对中枢神经系统突触生理学的 CB1R 独立影响。
  • 批准号:
    8225252
  • 财政年份:
    2011
  • 资助金额:
    $ 55.06万
  • 项目类别:
CB1R independent effects of cannabinoids on synaptic physiology in the CNS.
大麻素对中枢神经系统突触生理学的 CB1R 独立影响。
  • 批准号:
    8048639
  • 财政年份:
    2011
  • 资助金额:
    $ 55.06万
  • 项目类别:
Endocannabinoids and tonic GABA in the dentate gyrus.
齿状回中的内源性大麻素和补品 GABA。
  • 批准号:
    7093652
  • 财政年份:
    2005
  • 资助金额:
    $ 55.06万
  • 项目类别:
Endocannabinoids and tonic GABA in the dentate gyrus
齿状回中的内源性大麻素和补品 GABA
  • 批准号:
    7656750
  • 财政年份:
    2005
  • 资助金额:
    $ 55.06万
  • 项目类别:
Endocannabinoids and tonic GABA in the dentate gyrus
齿状回中的内源性大麻素和补品 GABA
  • 批准号:
    7460588
  • 财政年份:
    2005
  • 资助金额:
    $ 55.06万
  • 项目类别:
Endocannabinoids and tonic GABA in the dentate gyrus.
齿状回中的内源性大麻素和补品 GABA。
  • 批准号:
    7473458
  • 财政年份:
    2005
  • 资助金额:
    $ 55.06万
  • 项目类别:
Endocannabinoids and tonic GABA in the dentate gyrus
齿状回中的内源性大麻素和补品 GABA
  • 批准号:
    7242587
  • 财政年份:
    2005
  • 资助金额:
    $ 55.06万
  • 项目类别:
Endocannabinoids and tonic GABA in the dentate gyrus
齿状回中的内源性大麻素和补品 GABA
  • 批准号:
    6903677
  • 财政年份:
    2005
  • 资助金额:
    $ 55.06万
  • 项目类别:

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