Development of Preventive program for Obesity based on Health education and Self-determination

由于代谢综合征的优越性在日本有所增加，因此我们在2000年开始开发一个基于肥胖的健康教育和自我决定的干预计划。我们通过了一个基于学习原则的行为方案，以加强对饮食和锻炼的自我控制。该方案的目标是减掉1.0公斤的体重，并在膳食热量升高和每天保持7，000步的情况下减少10%的代谢测量值。24.8±3.0的身体质量指数为140名居民，年龄在Shimane Prefecture 35-70岁，在2000 - 2002年期间自愿参与了目前的研究。该方案三个月的下降率为2.9%。行为干预对能量、蛋白质和脂肪的增加产生了重要的影响，并在每天参与者的步骤中增加了数量。针对participants的干预induced a significant difference in weight-loss （-1.0 kg in 2001 and-1.8 kg in 2002）。Significan ... More 人体重量、体重指数、腰围和髋部循环、血压和脂质剖面中发现的人体测量参数并不不同，例如总胆固醇、LDL-胆固醇和HDL-胆固醇，2001年和2002年的干预。由于我们的程序是基于行为的参与者、意识和自主改进，因此很容易继续进行，以便用专家的复杂行为修饰描述来完成长期比较.在β_3-肾上腺素受体（β_3AR）中Trp 64 Arg突变的基因在日本人中是相对常见的。However，它还没有清除任何人在Trp 64 Arg突变中的β_3AR基因倾向于在任何受限制的饮食和锻炼中失去肥胖和困难。We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese women with Trp64 Arg mutation in the_3 AR gene。人体测量参数在身体重量、体重指数、腰围和髋部循环中发现了显著差异，以及野生类型的血液压力。However women with Trp64Arg mutation did not show significant changes in these anthropometics parameters， except for hip circumference。在HDL胆固醇（HDL-C）中发现了显著差异，在两种基因型中发现了LDL-胆固醇/HDL C的比率。目前研究的结果认为，β_3AR基因突变的Trp 64 Arg突变与通过行为干预失去体重的困难有关，但它与肥胖相关的表型和在干预之前恢复能量的消耗无关。Less（低）

Since the prevalence of metabolic syndrome is getting increase in Japanese, we conducted to develop an interventional program for obesity based on health education and self determination from 2000. We adopted the behavioral program to strengthen self-control of diet and exercise based on learning principles. Objectives of the program were to lose 1.0kg of weight and to reduce metabolic measurement values by 10% in dietary caloric intake and keep taking over 7,000 steps a day. Subjects were 140 residents with Body Mass Index of 24.8±3.0, aged 35-70 years in Shimane Prefecture, voluntarily participated in the present study in 2000 2002. The rate of drop out from the program for three months was 2.9%. The behavioral intervention induced significant decreases for intakes of energy, protein and fat, and an increase in the number of steps per day for participants. The intervention induced a significant difference in weight-loss (-1.0kg in 2001 and -1.8kg in 2002) for participants. Significan … More t differences of anthropometric parameters were found in body weight, BMI, waist and hip circumferences, blood pressure and lipid profile, such as total cholesterol, LDL-cholesterol, and HDL-cholesterol, by the intervention in 2001 and 2002. Since our program is based on the participants・awareness and autonomous improvement of behavior, it would be easier to continue for a long term compared to complying with specialist's complicated prescription of behavioristic modification.Trp64Arg mutation in the β_3-adrenergic receptor (β_3AR) gene is relatively common in Japanese people. However, it has not been clear whether persons with Trp64Arg mutation in the β_3AR gene tend to have obesity and difficulty in losing weight even with a restricted diet and exercise. We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese women with Trp64Arg mutation in the β_3AR gene. Significant differences of anthropometric parameters were found in body weight, BMI, waist and hip circumferences and blood pressure of wild type by the intervention. However women with Trp64Arg mutation did not show significant changes in these anthropometic parameters, except for hip circumference. A significant difference was found in HDL cholesterol (HDL-C) and in the LDL-cholesterol/HDL C ratio in both genotypes. Results of the present study suggest that the Trp64Arg mutation of the β_3AR gene is associated with difficulty in losing weight through the behavioral intervention, although it is not related to obesity-related phenotypes and resting energy expenditur before the intervention. Less