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Development of Preventive program for Obesity based on Health education and Self-determination

基于健康教育和自决的肥胖预防计划的制定

基本信息

批准号：
13680173
负责人：
NOGI Akiko
金额：
$ 1.34万
依托单位：
Shimane Prefectural Shimane Women's College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

Since the prevalence of metabolic syndrome is getting increase in Japanese, we conducted to develop an interventional program for obesity based on health education and self determination from 2000. We adopted the behavioral program to strengthen self-control of diet and exercise based on learning principles. Objectives of the program were to lose 1.0kg of weight and to reduce metabolic measurement values by 10% in dietary caloric intake and keep taking over 7,000 steps a day. Subjects were 140 residents with Body Mass Index of 24.8±3.0, aged 35-70 years in Shimane Prefecture, voluntarily participated in the present study in 2000 2002. The rate of drop out from the program for three months was 2.9%. The behavioral intervention induced significant decreases for intakes of energy, protein and fat, and an increase in the number of steps per day for participants. The intervention induced a significant difference in weight-loss (-1.0kg in 2001 and -1.8kg in 2002) for participants. Significan … More t differences of anthropometric parameters were found in body weight, BMI, waist and hip circumferences, blood pressure and lipid profile, such as total cholesterol, LDL-cholesterol, and HDL-cholesterol, by the intervention in 2001 and 2002. Since our program is based on the participants・awareness and autonomous improvement of behavior, it would be easier to continue for a long term compared to complying with specialist's complicated prescription of behavioristic modification.Trp64Arg mutation in the β_3-adrenergic receptor (β_3AR) gene is relatively common in Japanese people. However, it has not been clear whether persons with Trp64Arg mutation in the β_3AR gene tend to have obesity and difficulty in losing weight even with a restricted diet and exercise. We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese women with Trp64Arg mutation in the β_3AR gene. Significant differences of anthropometric parameters were found in body weight, BMI, waist and hip circumferences and blood pressure of wild type by the intervention. However women with Trp64Arg mutation did not show significant changes in these anthropometic parameters, except for hip circumference. A significant difference was found in HDL cholesterol (HDL-C) and in the LDL-cholesterol/HDL C ratio in both genotypes. Results of the present study suggest that the Trp64Arg mutation of the β_3AR gene is associated with difficulty in losing weight through the behavioral intervention, although it is not related to obesity-related phenotypes and resting energy expenditur before the intervention. Less

由于代谢综合征在日本的患病率越来越高，我们从2000年开始开展了一项基于健康教育和自我决定的肥胖干预计划。我们采用了基于学习原理的行为方案来加强饮食和运动的自我控制。该计划的目标是减肥1.0公斤，将膳食热量摄入的代谢测量值降低10%，每天保持7000步以上。研究对象为2000 ~ 2002年自愿参加本研究的岛根县居民140名，体重指数为24.8±3.0，年龄35 ~ 70岁。三个月的辍学率为2.9%。行为干预导致参与者的能量、蛋白质和脂肪摄入量显著减少，每天的步数增加。干预导致参与者体重减轻的显著差异（2001年为-1.0kg， 2002年为-1.8kg）。通过2001年和2002年的干预，在体重、BMI、腰臀围、血压和血脂指标（如总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇）方面发现了更多的差异。由于我们的项目是基于参与者的意识和自主行为的改善，与遵循专家复杂的行为矫正处方相比，长期坚持会更容易。β_3-肾上腺素能受体（β_3AR）基因Trp64Arg突变在日本人中比较常见。然而，β_3AR基因中Trp64Arg突变的人是否容易肥胖，即使限制饮食和运动也难以减肥，目前尚不清楚。我们研究了日本β_3AR基因Trp64Arg突变女性的体重和代谢因素对行为干预的反应。干预后野生型患者的体重、BMI、腰臀围、血压等人体测量参数均有显著差异。然而，Trp64Arg突变的女性在这些人体测量参数中没有表现出显著的变化，除了臀围。在两种基因型中，高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇/高密度脂蛋白C的比值有显著差异。本研究结果提示，β_3AR基因Trp64Arg突变与行为干预减肥困难相关，但与干预前肥胖相关表型和静息能量消耗无关。少