Development of Interfaces with Signal Transaction Ability and Its Application to Molecular Sensing

具有信号处理能力的接口开发及其在分子传感中的应用

• 批准号: 13680666
• 负责人: SUZUKI Iwao
• 金额: $ 2.3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680666/
• 关键词: Molecular recognition; Signal transduction; Coupled-host; Modified cyclodextrin; Alternately deposited film; Self assembled membrane; Environmental pollutant; Photo-regulation; 自己集合膜; 混合単分子膜; シクロデキストリン; クラウンエーテル; L-DOPA; ビピリジニウム; フェロセン; シクロ

According to the project plan, we have conducted following three projects; (1) development of the sophisticated host compounds capable of selective guest binding for which one could be informed by readily observable signals, (2) fabrication of organic thin films capable of molecular recognition and signal transduction, and (3) designing and development of "two-dimensional molecular imprinting" thin films that would be easily fabricated and would show excellent molecular recognition ability.Regarding the project (1), we have developed several novel cyclodextrin-based hosts possessing electron-rich or electron-deficient pendant residue. The pendants were covalentiy attached to cyclodextrin for not only improving the molecular recognition ability but also realizing excellent signal transduction. Of the hosts developed, pyrene-appended cyclodextrins were found as excellent hosts for bipyridinium and some halogenated compounds, which are known as environmental pollutants. We have also synth … More esized several cyclodextrin derivatives coupled with crownether or ammonium compound that exhibited different abilities on molecular recognition, and have found that the coupling concept was usable in constructing sophisticated host compounds even in aqueous solution.Regarding the project (2), we have successfully fabricated several organic thin films consisting of modified cyclodextrins, polyelectrolytes, or both. In addition, we have found that the molecular recognition ability of azobenzene-modified polyelecrolytes could be controlled by photo-isomerization of the azo groups, and that uniformly charged polyeletrolytes could be assembled by cyclodextrin complexation. Moreover, monolayers consisting of modified cyclodextrins were found to be thin film capable of discriminating charging state of the analytes.Regarding the projext (3), we have approached several ways to realize the "two-dimensional molecular imprinting" methodology by use of cyclodextrin, cnwnether, and positively or negatively charged alkanes based on the self-assembled technique. Unfortunately, we have not obtained mixed monolayers with good quality and molecular recognition properties. Further efforts must be required for |leveloping this concept. Less

根据项目计划，我们进行了三个项目。 （1）开发能够选择性宾客结合的复杂宿主化合物，可以通过易于观察的信号来告知它，（2）制造能够分子识别和信号翻译的有机薄膜，以及（3）设计和开发“二维分子刻画”的二维薄膜，这些薄膜可以易于制造，并且可以表现出一定能力的良好的识别。基于环糊精的宿主具有富含电子或电子缺陷式吊坠住宅。吊坠是共同连接到环糊精，不仅可以提高分子识别能力，而且还实现了出色的信号转导。在开发的宿主中，发现了吡啶的环糊精作为双吡啶丹和一些卤化化合​​物的出色宿主，这些宿主被称为环境污染物。我们还拥有合成器……更详细的几个环化学衍生物，再加上冠状或铵化合物，在分子识别上暴露了不同的能力，并且发现耦合概念在构造复杂的宿主化合物中也可以使用，即使在水性溶液中也可以使用。两个都。此外，我们发现，偶氮苯修饰的聚元解液的分子识别能力可以通过偶氮组的光相位来控制，并且可以通过环糊精络合来组装均匀带电的聚层。此外，发现由修改的环糊精组成的单层被发现是薄膜，能够区分分析物的充电状态。对项目进行重新标记（3），我们已经采取了几种方法来实现“二维分子烙印”方法，通过使用环脱氧蛋白，cnwnwnether，cnwnwnether和正面受到的Alkanes的启动，将其使用cyclodextrin，cysemed Orgented AlkaneS进行了负启动的Alkanes，该方法是由alkaneS进行了负。不幸的是，我们还没有获得具有良好质量和分子识别特性的混合单层。必须采取进一步的努力来升级此概念。较少的

项目成果

S.Yasuda, D.N.Futaba, 0.Takeuchi, I.Suzuki, K.Yase, J.Sumaoka, M.Komiyama, H.Shigekawa: "Monolayer formation of 6-deoxy-6thiol-β-cyclodextrin on a Au(111) surface studied by scanning tunneling microscopy"Journal of Vacuum Sciences and Technology A. 19巻. 1

S.Yasuda、D.N.Futaba、0.Takeuchi、I.Suzuki、K.Yase、J.Sumaoka、M.Komiyama、H.Shigekawa：“Au(111) 上 6-脱氧-6硫醇-β-环糊精的单层形成通过扫描隧道显微镜研究表面“真空科学与技术杂志 A.卷 19. 1

I.Suzuki, T.Ishizaki, T.Hoshi, J.Anzai: "Fully Reversible Isomerization of Azobenzene Chromophores in Polyclectrolyte Layered Assemblies"Macromolecules. 35巻. 577-580 (2002)

I.Suzuki、T.Ishizaki、T.Hoshi、J.Anzai：“聚电解质层状组件中偶氮苯发色团的完全可逆异构化”《高分子》35. 577-580 (2002)。

I.Suzuki, T.Ishizaki, T.Hoshi, J.Anzai: "Modification of Polyelectrolyte Layered Assemblies Using an Active Azobenzene Carboxylate"Macromolecules. 35巻. 6470-6474 (2002)

I.Suzuki、T.Ishizaki、T.Hoshi、J.Anzai：“使用活性偶氮苯羧酸盐对聚电解质层状组件进行改性”，《高分子》，第 35 卷，6470-6474 (2002)。

鈴木巌, 江川祐哉, 安斉順一: "シクロデキストリン単分子膜修飾電極におけるカテコールアミン類の応答"分析化学. 51巻. 403-407 (2002)

Iwao Suzuki、Yuya Ekawa、Junichi Anzai：“环糊精单层修饰电极上的儿茶酚胺响应”分析化学卷 51。403-407 (2002)

I.Suzuki, T.Ishizaki, T.Hoshi, J.Anzai: "Modification of Polyelectrolyte Layered Assemblies Using an Active Azobenzene Carboxylate"Macromolecules. 35. 6470-6474 (2002)

I.Suzuki、T.Ishizaki、T.Hoshi、J.Anzai：“使用活性偶氮苯羧酸盐对聚电解质层状组件进行改性”大分子。