Development of Interfaces with Signal Transaction Ability and Its Application to Molecular Sensing

具有信号处理能力的接口开发及其在分子传感中的应用

• 批准号: 13680666
• 负责人: SUZUKI Iwao
• 金额: $ 2.3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680666/
• 关键词: Molecular recognition; Signal transduction; Coupled-host; Modified cyclodextrin; Alternately deposited film; Self assembled membrane; Environmental pollutant; Photo-regulation; 自己集合膜; 混合単分子膜; シクロデキストリン; クラウンエーテル; L-DOPA; ビピリジニウム; フェロセン; シクロ

According to the project plan, we have conducted following three projects; (1) development of the sophisticated host compounds capable of selective guest binding for which one could be informed by readily observable signals, (2) fabrication of organic thin films capable of molecular recognition and signal transduction, and (3) designing and development of "two-dimensional molecular imprinting" thin films that would be easily fabricated and would show excellent molecular recognition ability.Regarding the project (1), we have developed several novel cyclodextrin-based hosts possessing electron-rich or electron-deficient pendant residue. The pendants were covalentiy attached to cyclodextrin for not only improving the molecular recognition ability but also realizing excellent signal transduction. Of the hosts developed, pyrene-appended cyclodextrins were found as excellent hosts for bipyridinium and some halogenated compounds, which are known as environmental pollutants. We have also synth … More esized several cyclodextrin derivatives coupled with crownether or ammonium compound that exhibited different abilities on molecular recognition, and have found that the coupling concept was usable in constructing sophisticated host compounds even in aqueous solution.Regarding the project (2), we have successfully fabricated several organic thin films consisting of modified cyclodextrins, polyelectrolytes, or both. In addition, we have found that the molecular recognition ability of azobenzene-modified polyelecrolytes could be controlled by photo-isomerization of the azo groups, and that uniformly charged polyeletrolytes could be assembled by cyclodextrin complexation. Moreover, monolayers consisting of modified cyclodextrins were found to be thin film capable of discriminating charging state of the analytes.Regarding the projext (3), we have approached several ways to realize the "two-dimensional molecular imprinting" methodology by use of cyclodextrin, cnwnether, and positively or negatively charged alkanes based on the self-assembled technique. Unfortunately, we have not obtained mixed monolayers with good quality and molecular recognition properties. Further efforts must be required for |leveloping this concept. Less

根据项目计划，我们开展了以下三个项目：(1)开发能够通过容易观察到的信号来选择性客体结合的复杂主体化合物，(2)制备具有分子识别和信号转导能力的有机薄膜，以及(3)设计和开发易于制备并具有良好分子识别能力的“二维分子印迹”薄膜。将其共价连接到环糊精上，不仅提高了分子识别能力，而且实现了良好的信号转导。在所开发的宿主中，添加了芘的环糊精被发现是联吡啶和一些卤代化合物的良好宿主，这些化合物被称为环境污染物。我们还有Synth…进一步研究了几种具有不同分子识别能力的环糊精衍生物与冠醚或氨基化合物的偶联，发现偶联概念即使在水溶液中也可用于构建复杂的主体化合物。关于项目(2)，我们成功地制备了几种由改性环糊精和/或聚电解质组成的有机薄膜。此外，我们还发现偶氮苯修饰的聚电解质的分子识别能力可以通过偶氮基团的光致异构化来控制，而均匀带电的聚电解质可以通过环糊精的络合作用来组装。此外，我们还发现由修饰的环糊精组成的单分子膜可以区分分析物的荷电状态。关于方案(3)，我们探讨了几种基于自组装技术的利用环糊精、顺式和带正负电荷的烷烃实现“二维分子印迹”方法的方法。遗憾的是，我们还没有得到具有良好质量和分子识别性能的混合单分子膜。要发展这一概念，还需要进一步的努力。较少

项目成果

S.Yasuda, D.N.Futaba, 0.Takeuchi, I.Suzuki, K.Yase, J.Sumaoka, M.Komiyama, H.Shigekawa: "Monolayer formation of 6-deoxy-6thiol-β-cyclodextrin on a Au(111) surface studied by scanning tunneling microscopy"Journal of Vacuum Sciences and Technology A. 19巻. 1

S.Yasuda、D.N.Futaba、0.Takeuchi、I.Suzuki、K.Yase、J.Sumaoka、M.Komiyama、H.Shigekawa：“Au(111) 上 6-脱氧-6硫醇-β-环糊精的单层形成通过扫描隧道显微镜研究表面“真空科学与技术杂志 A.卷 19. 1

I.Suzuki, T.Ishizaki, T.Hoshi, J.Anzai: "Modification of Polyelectrolyte Layered Assemblies Using an Active Azobenzene Carboxylate"Macromolecules. 35巻. 6470-6474 (2002)

I.Suzuki、T.Ishizaki、T.Hoshi、J.Anzai：“使用活性偶氮苯羧酸盐对聚电解质层状组件进行改性”，《高分子》，第 35 卷，6470-6474 (2002)。

I.Suzuki, T.Ishizaki, T.Hoshi, J.Anzai: "Fully Reversible Isomerization of Azobenzene Chromophores in Polyclectrolyte Layered Assemblies"Macromolecules. 35巻. 577-580 (2002)

I.Suzuki、T.Ishizaki、T.Hoshi、J.Anzai：“聚电解质层状组件中偶氮苯发色团的完全可逆异构化”《高分子》35. 577-580 (2002)。

鈴木巌, 江川祐哉, 安斉順一: "シクロデキストリン単分子膜修飾電極におけるカテコールアミン類の応答"分析化学. 51巻. 403-407 (2002)

Iwao Suzuki、Yuya Ekawa、Junichi Anzai：“环糊精单层修饰电极上的儿茶酚胺响应”分析化学卷 51。403-407 (2002)

I.Suzuki, Y.Kato, Y.Egawa, J.Anzai, M.Wadamori, H.Yokomizo, K.Takahashi: "Structural Aspects of Marked Difference in Intramolecular Exciplex Emissions from Selfcomplexes of β-Cyclodextrins Modified with (R)- or (S)-1-(1-aminoethyl)naphthalene"Journal of M

I.Suzuki、Y.Kato、Y.Egawa、J.Anzai、M.Wadamori、H.Yokomizo、K.Takahashi：“用 (R)- 修饰的 β-环糊精自复合物的分子内激基复合物发射的结构方面存在显着差异或(S)-1-(1-氨基乙基)萘”M杂志