Definitive Diagnosis And Intensive Monitor Of Prostate Diseases Based On Magnetic Resonance Spectroscopic Imaging

基于磁共振波谱成像的前列腺疾病确诊和强化监测

• 批准号: 13680953
• 负责人: KURODA Kagayaki
• 金额: $ 2.75万
• 依托单位: TOKAI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680953/
• 关键词: MRI; MRS; Proton; Prostate; Metabolite; Citrate; pH; Temperature; プロトン; MRSI; コリン; スペクトル

It was found that the proton chemical shift of citrate has pH dependency of -0.09 ppm/pH, while that of choline or creatine has no pH dependency. The prostate metabolite measurement system based upon magnetic resonance spectroscopic imaging (MRSI) with the very high tesla (3T) magnet has been constructed. It was also found based on the phantom experiments that the intensity of the citrate signal is modulated by J-coupling and the chemical shift, and that the highest echo signal appears at the echo time of 290 ms. Density matrix simulation adopting J-modulation factor, chemical shift, pulse timing and T2 showed that the highest echo signal of citrate proton appears around 290 ms when the citrate T2 is longer than 133 ms while it is around 145 ms when the T2 is shorter than 133 ms. By fitting the volunteer data on the simulation model curve derived from the density matrix calculation, the citrate T2 value, which has not been reported so far, was estimated as approximately 80 ms.As for th … More e MR probe development; a new coil element configuration with two pairs of loop coils was developed. Although we first examined suppression of thermal noise by cooling the coil to improve signal to noise, it turned out that increasing signal intensity by minimizing the distance between prostate and the coil elements, and by finely adjusting the shapes of the elements are more significant. The new coil design improved the signal to noise 2.1 times at the peripheral zone and 1.3 times at the central zone of prostate compared with the phased array coil used with a 1.5 T scanner.Imaging sequence was optimized based on the prostate coil by adjusting the outer volume suppression pulses, water suppression pulses as well as spatial-frequency excitation pulses. High-resolution diagnostic anatomical images as well as high quality metabolite spectra were constantly obtained for twenty healthy volunteers. The spectral band width and signal to noise ratio (S/N) were smaller than 0.1 ppm and higher than 10, respectively, for citrate in the healthy prostates. Scans for patient volunteers with prostate cancers were started at the end of this annual year to examine the ability of the metabolite measurement system for the definitive diagnosis of prostate cancer and benign prostatic hyperplasia (BPH). It is our duty to continuously examine the patient volunteers to establish a practical prostate observation system based on the results obtained by this grant-in-aid.We deeply thank to the Japan Society for the Promotion of Science (JSPS) for supporting our research. Less

发现柠檬酸盐的质子化学位移具有-0.09 ppm/pH的pH依赖性，而胆碱或肌酸的质子化学位移没有pH依赖性。建立了基于超高特斯拉（3 T）磁共振波谱成像（MRSI）的前列腺代谢物测量系统。基于体模实验还发现，柠檬酸盐信号的强度受到J耦合和化学位移的调制，最高回波信号出现在回波时间为290 ms处。脉冲定时和T2显示，当柠檬酸盐T2长于133 ms时，柠檬酸盐质子的最高回波信号出现在290 ms左右，而在145 ms左右当T2短于133 ms时，通过将志愿者数据拟合在由密度矩阵计算得出的模拟模型曲线上，柠檬酸盐T2值（迄今为止尚未报道）估计为约80 ms。 ...更多信息 e MR探头开发;开发了具有两对环形线圈的新线圈元件配置。虽然我们首先检查了通过冷却线圈以改善信噪比来抑制热噪声，但事实证明，通过最小化前列腺和线圈元件之间的距离以及通过精细调整元件的形状来增加信号强度更重要。与1.5T扫描仪上使用的相控阵线圈相比，新的线圈设计在前列腺边缘区的信噪比提高了2.1倍，在前列腺中心区的信噪比提高了1.3倍，通过调整外容积抑制脉冲、水抑制脉冲和空间频率激励脉冲，优化了前列腺线圈的成像序列。高分辨率的诊断解剖图像，以及高品质的代谢物光谱不断获得20名健康志愿者。健康前列腺中柠檬酸盐的光谱带宽和信噪比（S/N）分别小于0.1 ppm和大于10。今年年底开始对前列腺癌患者志愿者进行扫描，以检查代谢物测量系统对前列腺癌和良性前列腺增生（BPH）的明确诊断能力。我们有责任继续对患者志愿者进行检查，以建立基于该资助的结果的实用前列腺观察系统。我们深深感谢日本科学促进协会（JSPS）对我们研究的支持。少

项目成果

Yasushi Kaji, Kagayaki Kuroda, Naoyuki Takei, Tetsuji Tsukamoto, Kazuro Sugimura: "Homo-nuclear coupling of citrate observed by a 3 tesla"MRI, JJMR. 21S. (2001)

Yasushi Kaji、Kagayaki Kuroda、Naoyuki Takei、Tetsuji Tsukamoto、Kazuro Sugimura：“通过 3 特斯拉观察到的柠檬酸盐的同核耦合”MRI，JJMR。

K.Kuroda, Y.Kaji, RV Mulkern, N.Takei, Y.Kitamura, M.Tamura, K.Sugimura: "MR Observations of Prostate Metabolites at 3 Tesla"Proc.10th Meeting ISMRM. 3. 1921 (2002)

K.Kuroda、Y.Kaji、RV Mulkern、N.Takei、Y.Kitamura、M.Tamura、K.Sugimura：“3 特斯拉下前列腺代谢物的 MR 观察”Proc.10th Meeting ISMRM。

Yasushi Kaji, Kazuro Sugimura, Yuri Kitamura, Naoyuki Takei, Kagayaki Kuroda, Tetsuji Tsukamoto: "The Impact of the very high tesla MRI: Expectation for Prostate, MRI and MRS"Image Medicine. 34, 5. 438-442 (2002)

Yasushi Kaji、Kazuro Sugimura、Yuri Kitamura、Naoyuki Takei、Kagayaki Kuroda、Tetsuji Tsukamoto：“超高特斯拉 MRI 的影响：对前列腺、MRI 和 MRS 的期望”影像医学。

Yasushi Kaji, Kagayaki Kuroda, Takaki Maeda, Yuri Kitamura, Yuichiro Matsuoka, Tsuyoshi Matsuda, Tetsuji Tsukamoto, Kazuro Sugimura: "MR Imaging and Spectroscopy of Prostate at 3 Tesla"Proc. 11th Annual Meeting ISMRM. 1542 (2003)

Yasushi Kaji、Kagayaki Kuroda、Takaki Maeda、Yuri Kitamura、Yuichiro Matsuoka、Tsuyoshi Matsuda、Tetsuji Tsukamoto、Kazuro Sugimura：“3 特斯拉前列腺的 MR 成像和光谱”Proc。

Yasushi Kaji, Kagayaki Kuroda, Takaki Maeda, Yuri Kitamura, Yuichiro Matsuoka, Tsuyoski Matsuda, Tetsuji Tsukamoto, Kazuro Sugimura: "MR Imaging and MR Spectroscopy of Prostate at 3 Tesla"Proc.11th Annual Meeting ISMRM. 1542 (2003)

Yasushi Kaji、Kagayaki Kuroda、Takaki Maeda、Yuri Kitamura、Yuichiro Matsuoka、Tsuyoski Matsuda、Tetsuji Tsukamoto、Kazuro Sugimura：“3 特斯拉下前列腺的 MR 成像和 MR 光谱”Proc.11th 年会 ISMRM。