effect of atypical antipsychotics on brain morphometry in schizophrenia

发现精神分裂症患者颞上回形态测量异常与记忆障碍和认知障碍有关。此外，使用优化的基于体素的形态测量法（VBM）对精神分裂症患者和正常人之间的形态学变化进行了测试。结果显示，双侧额叶区、颞上回、右侧海马和右侧扣带回皮质体积减少。根据精神分裂症患者罗夏测验的认知得分分为两组。采用优化后的VBM对两组精神分裂症患者进行脑MRI分析。认知功能低的患者与认知功能高的患者相比，左侧颞上回体积减小。初步优化VBM分析，比较常规抗精神病药物和非典型抗精神病药物治疗组之间的差异。使用常规抗精神病药的患者双侧扣带皮层、右侧额叶中皮层和右侧颞上皮层皮质体积减小。

Association of morphometric abnormalities were found with memory disturbances and cognitive impairment in superior temporal gyrus for patients with schizophrenia. In addition, the morphometric changes were also tested using optimized voxel-based Morphometry (VBM) between patients with schizophrenia and normal subjects. Findings suggested that cortical volumes were reduced in bilateral frontal area and superior temporal gyrus, and right hippocampus and right cingulate gyrus. Two groups were divided based on cognitive scores by Rorschach test for patients with schizophrenia. Brain MRI was analyzed using optimized VBM in the two schizophrenia groups. Patients with low cognitive function showed volume reduction in left anterior superior temporal gyrus compared to group with high cognitive function.Preliminary optimized VBM analysis was tested to compare between two treatment groups with conventional antipsychotics and atypical antipsychotics. Patients with conventional neuroleptics showed reduced cortical volumes in bilateral cingulated cortex, right middle frontal cortex and right superior temporal cortex.