Cognitive dysfunction, brain structural abnormality and molecular biological vulnerability in schizophrenia

101名18岁以上的精神分裂症患者（男：女=39:62）接受了MRI扫描。使用MRI体积法估计全脑灰质、白质和脑脊液中与年龄相关的体积变化模式。与疾病特异性认知功能障碍相关的脑区域体积减少也被显示出来。此外，与其他类型组相比，眼窝额叶皮质（OFC）硫回模式伴有BDNF Val/Val基因型的II型组是一个显著的小群体。BDNF基因型可能在一定程度上提供OFC磺基旋回的形成，并参与精神分裂症的发展。

One hundred and one patients (male:female=39:62) with schizophrenia over 18 years old underwent MRI scans in this study. The patterns of age-related volumes changes in the whole brain gray matter, white matter and cerebrospinal fluid were estimated using MRI volumetry. Brain regions with volume reduction related to disease-specific cognitive dysfunction was also shown. In addition, the type II group of Orbito-Frontal Cortex (OFC) sulcogyral pattern with BDNF Val/Val genotype was a significant small population compared with other type groups in schizophrenia. The BDNF genotype may partially provide the OFC sulcogyral formation and involve the development in schizophrenia.